Publications by authors named "Mark Bothwell"

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An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing.
Jacob W Fleming, Molly C McCloskey, Kevin Gray, David R Nash, Vincent Leung, Mark Bothwell

Curr Res Toxicol· January 2025

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Human Motor Neurons Elicit Pathological Hallmarks of ALS and Reveal Potential Biomarkers of the Disease in Response to Prolonged IFNγ Exposure.
Changho Chun, Jung Hyun Lee, Mark Bothwell, Paul Nghiem, Alec S T Smith

J Neurosci· April 2024

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Editorial: Modeling neuromuscular diseases to determine molecular drivers of pathology and for drug discovery.
Alec S T Smith, Megan L McCain, Mark Bothwell, David L Mack

Front Cell Dev Biol· October 2022

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Conformational sampling of CMT-2D associated GlyRS mutations.
Matthew Carter Childers, Michael Regnier, Mark Bothwell, Alec S T Smith

Brain Multiphys· September 2022

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HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D).
Alec S T Smith, Jong Hyun Kim, Changho Chun, Ava Gharai, Hyo Won Moon, Mark Bothwell

Adv Biol (Weinh)· February 2022

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Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies.
Alec S T Smith, Changho Chun, Jennifer Hesson, Julie Mathieu, Paul N Valdmanis, Mark Bothwell

Front Cell Dev Biol· September 2021

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Astrocyte-derived extracellular vesicles enhance the survival and electrophysiological function of human cortical neurons in vitro.
Changho Chun, Alec S T Smith, Hyejin Kim, Dana S Kamenz, Jung Hyun Lee, Mark Bothwell

Biomaterials· April 2021

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Recent advances in understanding context-dependent mechanisms controlling neurotrophin signaling and function.
Mark Bothwell

F1000Res· October 2019

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Mechanisms and Medicines for Remyelination.
Mark Bothwell

Annu Rev Med· January 2017

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Recent advances in understanding neurotrophin signaling.
Mark Bothwell

F1000Res· August 2016

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Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling.
James S Meabon, Rian de Laat, Katsuaki Ieguchi, Dmitry Serbzhinsky, Mark P Hudson, Mark Bothwell

Mol Cell Neurosci· January 2016

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LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments.
James S Meabon, Rian De Laat, Katsuaki Ieguchi, Jesse C Wiley, Mark P Hudson, Mark Bothwell

J Biol Chem· April 2015

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LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor.
Rian de Laat, James S Meabon, Jesse C Wiley, Mark P Hudson, Thomas J Montine, Mark Bothwell

Pathobiol Aging Age Relat Dis· March 2015

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Intense and specialized dendritic localization of the fragile X mental retardation protein in binaural brainstem neurons: a comparative study in the alligator, chicken, gerbil, and human.
Yuan Wang, Hitomi Sakano, Karisa Beebe, Maile R Brown, Rian de Laat, Mark Bothwell

J Comp Neurol· June 2014

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TrkB downregulation is required for dendrite retraction in developing neurons of chicken nucleus magnocellularis.
Leslayann C Schecterson, Jason Tait Sanchez, Edwin W Rubel, Mark Bothwell

J Neurosci· October 2012

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Trk activation in the secretory pathway promotes Golgi fragmentation.
Leslayann C Schecterson, Mark P Hudson, Mabel Ko, Polyxeni Philippidou, Wendy Akmentin, Mark Bothwell

Mol Cell Neurosci· April 2010

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Neurotrophin receptors: Old friends with new partners.
Leslayann C Schecterson, Mark Bothwell

Dev Neurobiol· April 2010

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Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells.
Jesse C Wiley, James S Meabon, Harald Frankowski, Elise A Smith, Leslayann C Schecterson, Mark Bothwell

PLoS One· February 2010

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LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development.
Kenji Mandai, Ting Guo, Coryse St Hillaire, James S Meabon, Kevin C Kanning, Mark Bothwell

Neuron· September 2009

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Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers.
Marçal Vilar, Ioannis Charalampopoulos, Rajappa S Kenchappa, Anastasia Simi, Esra Karaca, Mark Bothwell

Neuron· April 2009

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An all-purpose tool for axon guidance.
Leslayann C Schecterson, Mark Bothwell

Sci Signal· November 2008

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Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain.
Jesse C Wiley, Elise A Smith, Mark P Hudson, Warren C Ladiges, Mark Bothwell

J Biol Chem· November 2007

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Evolution of the neurotrophin signaling system in invertebrates.
Mark Bothwell

Brain Behav Evol· October 2006

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Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F.
Nan E Hatch, Mark Hudson, Marianne L Seto, Michael L Cunningham, Mark Bothwell

J Biol Chem· September 2006

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FGF2 alters expression of the pyrophosphate/phosphate regulating proteins, PC-1, ANK and TNAP, in the calvarial osteoblastic cell line, MC3T3E1(C4).
Nan E Hatch, Francisco Nociti, Erica Swanson, Mark Bothwell, Martha Somerman

Connect Tissue Res· April 2006

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