Publications by authors named "David Levens"

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A tumorigenesis threshold for endogenous Myc revealed by dosage-compensation for Myc-haploinsufficiency in the absence of p53.
Xiaozhong Bao, Zied Abdullaev, Subhendu K Das, Valerie Zgonc, Kris Ylaya, David Levens

bioRxiv· July 2025

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Topoisomerase Regulation of Cancer Gene Expression.
Laura Baranello, Fedor Kouzine, David Levens

Annu Rev Biochem· June 2025

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The plusses and minuses of DNA torsion.
Steven Henikoff, David L Levens

Elife· March 2025

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Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome.
Subhendu K Das, Sharmistha Karmakar, Harish Venkatachalapathy, Rajiv Kumar Jha, Eric Batchelor, David Levens

Mol Cell· November 2024

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Self-assembly of promoter DNA and RNA Pol II machinery into transcriptionally active biomolecular condensates.
Brian A Lewis, Subhendu Kumar Das, Rajiv Kumar Jha, David Levens

Sci Adv· October 2023

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MYC function and regulation in physiological perspective.
Rajiv Kumar Jha, Fedor Kouzine, David Levens

Front Cell Dev Biol· October 2023

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MYC: a complex problem.
Subhendu K Das, Brian A Lewis, David Levens

Trends Cell Biol· March 2023

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Detection of Z-DNA Structures in Supercoiled Genome.
Fedor Kouzine, Damian Wojtowicz, Teresa M Przytycka, David Levens

Methods Mol Biol· March 2023

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Psi promotes Drosophila wing growth via direct transcriptional activation of cell cycle targets and repression of growth inhibitors.
Olga Zaytseva, Naomi C Mitchell, Damien Muckle, Caroline Delandre, Zuqin Nie, David L Levens

Development· January 2023

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Mechanical determinants of chromatin topology and gene expression.
Rajiv Kumar Jha, David Levens, Fedor Kouzine

Nucleus· December 2022

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Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function.
Aiste Dobrovolskaite, Holly Moots, Mukund P Tantak, Kunal Shah, Jenna Thomas, David Levens

J Med Chem· November 2022

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Non-equilibrium structural dynamics of supercoiled DNA plasmids exhibits asymmetrical relaxation.
Cynthia Shaheen, Cameron Hastie, Kimberly Metera, Shane Scott, Zhi Zhang, David Levens

Nucleic Acids Res· March 2022

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MYC assembles and stimulates topoisomerases 1 and 2 in a "topoisome".
Subhendu K Das, Vladislav Kuzin, Donald P Cameron, Suzanne Sanford, Rajiv Kumar Jha, David Levens

Mol Cell· January 2022

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MYC amplifies gene expression through global changes in transcription factor dynamics.
Simona Patange, David A Ball, Yihan Wan, Tatiana S Karpova, Michelle Girvan, David Levens

Cell Rep· January 2022

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Targeting CDK9 for the Treatment of Glioblastoma.
Alice Ranjan, Ying Pang, Madison Butler, Mythili Merchant, Olga Kim, David Levens

Cancers (Basel)· June 2021

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Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.
Adam J Wolpaw, Richard Bayliss, Gabriele Büchel, Chi V Dang, Martin Eilers, David Levens

Cancer Res· April 2021

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FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells.
Ying Zheng, Wendy Dubois, Craig Benham, Eric Batchelor, David Levens

Commun Biol· October 2020

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Dissecting transcriptional amplification by MYC.
Zuqin Nie, Chunhua Guo, Subhendu K Das, Carson C Chow, Eric Batchelor, David Levens

Elife· July 2020

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MYC protein stability is negatively regulated by BRD4.
Ballachanda N Devaiah, Jie Mu, Ben Akman, Sheetal Uppal, Jocelyn D Weissman, David Levens

Proc Natl Acad Sci U S A· June 2020

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Transcriptional repression of Myc underlies the tumour suppressor function of AGO1 in .
Olga Zaytseva, Naomi C Mitchell, Linna Guo, Owen J Marshall, Linda M Parsons, David L Levens

Development· June 2020

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In Vivo Chemical Probing for G-Quadruplex Formation.
Fedor Kouzine, Damian Wojtowicz, Arito Yamane, Rafael Casellas, Teresa M Przytycka, David L Levens

Methods Mol Biol· April 2020

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The Texture of Chromatin.
Fedor Kouzine, David Levens

Cell· October 2019

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Single-molecule visualization of the effects of ionic strength and crowding on structure-mediated interactions in supercoiled DNA molecules.
Shane Scott, Cynthia Shaheen, Brendon McGuinness, Kimberly Metera, Fedor Kouzine, David Levens

Nucleic Acids Res· July 2019

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The Energetics and Physiological Impact of Cohesin Extrusion.
Laura Vian, Aleksandra Pękowska, Suhas S P Rao, Kyong-Rim Kieffer-Kwon, Seolkyoung Jung, David Levens

Cell· September 2018

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The Energetics and Physiological Impact of Cohesin Extrusion.
Laura Vian, Aleksandra Pękowska, Suhas S P Rao, Kyong-Rim Kieffer-Kwon, Seolkyoung Jung, David Levens

Cell· May 2018

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