Publications by authors named "David M Frucht"

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A new STAT3-based potency assay for human G-CSF analog therapeutics.
Tao Xie, Weiming Ouyang, Yaqin Zhang, Phillip Angart, Patrick J Lynch, David M Frucht

J Pharm Biomed Anal· November 2025

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Interchangeability of the Assays Used to Assess the Activity of Anti-SARS-CoV-2 Monoclonal Antibodies.
Brady T Hickerson, Alexey M Khalenkov, Tao Xie, David M Frucht, Dorothy E Scott

Viruses· August 2023

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Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics.
Weiming Ouyang, Tao Xie, Hui Fang, David M Frucht

Toxins (Basel)· August 2023

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Variable Induction of Pro-Inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In Vivo.
Weiming Ouyang, Tao Xie, Hui Fang, Chunling Gao, Tzanko Stantchev, David M Frucht

Int J Mol Sci· July 2021

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Erk1/2 Inactivation-Induced c-Jun Degradation Is Regulated by Protein Phosphatases, UBE2d3, and the C-Terminus of c-Jun.
Weiming Ouyang, David M Frucht

Int J Mol Sci· April 2021

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Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates.
Weiming Ouyang, Pengfei Guo, Kazuyo Takeda, Qiong Fu, Hui Fang, David M Frucht

Proc Natl Acad Sci U S A· February 2020

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The ELISA Detectability and Potency of Pegfilgrastim Decrease in Physiological Conditions: Key Roles for Aggregation and Individual Variability.
Tao Xie, Hui Fang, Weiming Ouyang, Phillip Angart, Meng-Jung Chiang, David M Frucht

Sci Rep· February 2020

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Gastric pH and Toxin Factors Modulate Infectivity and Disease Progression After Gastrointestinal Exposure to Bacillus anthracis.
Tao Xie, David Rotstein, Chen Sun, Hui Fang, David M Frucht

J Infect Dis· December 2017

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A New Murine Model for Gastrointestinal Anthrax Infection.
Tao Xie, Chen Sun, Kadriye Uslu, Roger D Auth, Hui Fang, David M Frucht

PLoS One· October 2017

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Anthrax lethal toxin rapidly reduces c-Jun levels by inhibiting c-Jun gene transcription and promoting c-Jun protein degradation.
Weiming Ouyang, Pengfei Guo, Hui Fang, David M Frucht

J Biol Chem· October 2017

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Passive Immunotherapy Protects against Enteric Invasion and Lethal Sepsis in a Murine Model of Gastrointestinal Anthrax.
Bruce Huang, Tao Xie, David Rotstein, Hui Fang, David M Frucht

Toxins (Basel)· September 2015

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Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.
Hye Sun Kuehn, Weiming Ouyang, Bernice Lo, Elissa K Deenick, Julie E Niemela, David M Frucht

Science· September 2014

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Correlating interleukin-12 stimulated interferon-γ production and the absence of ectodermal dysplasia and anhidrosis (EDA) in patients with mutations in NF-κB essential modulator (NEMO).
Margje H Haverkamp, Beatriz E Marciano, David M Frucht, Ashish Jain, Esther van de Vosse

J Clin Immunol· May 2014

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Anthrax lethal toxin inhibits translation of hypoxia-inducible factor 1α and causes decreased tolerance to hypoxic stress.
Weiming Ouyang, Chikako Torigoe, Hui Fang, Tao Xie, David M Frucht

J Biol Chem· February 2014

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Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency.
Carrie L Lucas, Hye Sun Kuehn, Fang Zhao, Julie E Niemela, Elissa K Deenick, David M Frucht

Nat Immunol· January 2014

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Anthrax lethal toxin disrupts intestinal barrier function and causes systemic infections with enteric bacteria.
Chen Sun, Hui Fang, Tao Xie, Roger D Auth, Nayana Patel, David M Frucht

PLoS One· August 2012

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Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome.
Amy P Hsu, Elizabeth P Sampaio, Javed Khan, Katherine R Calvo, Jacob E Lemieux, David M Frucht

Blood· September 2011

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The effects of anthrax lethal toxin on host barrier function.
Tao Xie, Roger D Auth, David M Frucht

Toxins (Basel)· June 2011

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Neutrophil elastase mediates pathogenic effects of anthrax lethal toxin in the murine intestinal tract.
Hui Fang, Chen Sun, Lixin Xu, Robert J Owen, Roger D Auth, David M Frucht

J Immunol· November 2010

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Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia.
Donald C Vinh, Smita Y Patel, Gulbu Uzel, Victoria L Anderson, Alexandra F Freeman, David M Frucht

Blood· February 2010

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Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii.
Wendy T Watford, Bruce D Hissong, Lydia R Durant, Hidehiro Yamane, Linda M Muul, David M Frucht

J Exp Med· November 2008

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Anthrax lethal toxin increases superoxide production in murine neutrophils via differential effects on MAPK signaling pathways.
Lixin Xu, Hui Fang, David M Frucht

J Immunol· March 2008

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STAT3 mutations in the hyper-IgE syndrome.
Steven M Holland, Frank R DeLeo, Houda Z Elloumi, Amy P Hsu, Gulbu Uzel, David M Frucht

N Engl J Med· October 2007

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Bacillus anthracis: a multi-faceted role for anthrax lethal toxin in thwarting host immune defenses.
Lixin Xu, David M Frucht

Int J Biochem Cell Biol· February 2007

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X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production.
Orchidée Filipe-Santos, Jacinta Bustamante, Margje H Haverkamp, Emilie Vinolo, Cheng-Lung Ku, David M Frucht

J Exp Med· July 2006

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