Publications by authors named "David P Jacobus"

Claim this Profile
efficacy of next-generation dihydrotriazines and biguanides against babesiosis and malaria parasites.
Pratap Vydyam, Meenal Chand, Shalev Gihaz, Isaline Renard, Gavin D Heffernan, Laura R Jacobus, David P Jacobus

Antimicrob Agents Chemother· September 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Relevance of Higher-Order Epistasis in Drug Resistance.
Elena R Lozovsky, Rachel F Daniels, Gavin D Heffernan, David P Jacobus, Daniel L Hartl

Mol Biol Evol· January 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against .
Geoffrey W Birrell, Matthew P Challis, Amanda De Paoli, Dovile Anderson, Shane M Devine, David P Jacobus

Mol Cell Proteomics· February 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Monkey-Human Malaria Model.
Fiona J McCallum, Geoffrey W Birrell, Marina Chavchich, Ivor Harris, Nicanor Obaldia, David P Jacobus

Antimicrob Agents Chemother· February 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
V
Validation of the triple timed up-and-go test in Lambert-Eaton myasthenia.
Shruti M Raja, Donald B Sanders, Vern C Juel, Yadollah Harati, A Gordon Smith, Laura R Jacobus, David P Jacobus

Muscle Nerve· September 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
3
3,4-diaminopyridine base effectively treats the weakness of Lambert-Eaton myasthenia.
Donald B Sanders, Vern C Juel, Yadollah Harati, A Gordon Smith, Amanda C Peltier, Laura R Jacobus, David P Jacobus

Muscle Nerve· April 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention.
Geoffrey W Birrell, Gavin D Heffernan, Guy A Schiehser, John Anderson, Arba L Ager, Laura R Jacobus, David P Jacobus

Antimicrob Agents Chemother· April 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Reliability of the triple-timed up-and-go test.
Donald B Sanders, Jeffrey T Guptill, Kathy L Aleš, Lisa D Hobson-Webb, David P Jacobus

Muscle Nerve· January 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention.
Marina Chavchich, Geoffrey W Birrell, Arba L Ager, Donna O MacKenzie, Gavin D Heffernan, Laura R Jacobus, David P Jacobus

Antimicrob Agents Chemother· May 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Evaluation of the 2-Aminomethylphenol JPC-2997 in Aotus Monkeys Infected with Plasmodium falciparum.
Fiona McCallum, Ivor Harris, Karin van Breda, Sai Lata De, Danielle I Stanisic, David P Jacobus

Antimicrob Agents Chemother· December 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
J
JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium.
Geoffrey W Birrell, Marina Chavchich, Arba L Ager, Hong-Ming Shieh, Gavin D Heffernan, Laura R Jacobus, David P Jacobus

Antimicrob Agents Chemother· January 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.
Gustavo A Afanador, Stephen P Muench, Martin McPhillie, Alina Fomovska, Arne Schön, David P Jacobus

Biochemistry· December 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel diaryl ureas with efficacy in a mouse model of malaria.
John W Anderson, Dimitri Sarantakis, Jacek Terpinski, T R Santha Kumar, Han-Chun Tsai, David P Jacobus

Bioorg Med Chem Lett· February 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis.
Joel S Freundlich, Feng Wang, Catherine Vilchèze, Gulcin Gulten, Robert Langley, David P Jacobus

ChemMedChem· February 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Min Yu, T R Santha Kumar, Louis J Nkrumah, Alida Coppi, Silke Retzlaff, David P Jacobus

Cell Host Microbe· December 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo.
Ernest J Mui, Guy A Schiehser, Wilbur K Milhous, Honghue Hsu, Craig W Roberts, David P Jacobus

PLoS Negl Trop Dis· March 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines.
Damaris S Diaz, Michael P Kozar, Kirsten S Smith, Constance O Asher, Jason C Sousa, David P Jacobus

Drug Metab Dispos· February 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate--JPC2056--in cynomolgus monkeys using an in vivo in vitro model.
Michael D Edstein, Barbara M Kotecka, Arba L Ager, Kirsten S Smith, Charles A DiTusa, David P Jacobus

J Antimicrob Chemother· October 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
X
X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.
Joel S Freundlich, Feng Wang, Han-Chun Tsai, Mack Kuo, Hong-Ming Shieh, David P Jacobus

J Biol Chem· August 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.
Joel S Freundlich, Min Yu, Edinson Lucumi, Mack Kuo, Han-Chun Tsai, David P Jacobus

Bioorg Med Chem Lett· April 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of the optimal third generation antifolate against P. falciparum and P. vivax.
Sonia Y Hunt, Carsten Detering, Gabriele Varani, David P Jacobus, Guy A Schiehser

Mol Biochem Parasitol· December 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.
Joel S Freundlich, John W Anderson, Dimitri Sarantakis, Hong-Ming Shieh, Min Yu, David P Jacobus

Bioorg Med Chem Lett· December 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
In vitro metabolism of phenoxypropoxybiguanide analogues in human liver microsomes to potent antimalarial dihydrotriazines.
Todd W Shearer, Michael P Kozar, Michael T O'Neil, Philip L Smith, Guy A Schiehser, David P Jacobus

J Med Chem· April 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase.
A'Lissa B Gerum, Jonathan E Ulmer, David P Jacobus, Norman P Jensen, David R Sherman

Antimicrob Agents Chemother· November 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis