Publications by authors named "David Printzenhoff"

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PF-06526290 can both enhance and inhibit conduction through voltage-gated sodium channels.
Lingxin Wang, Shannon G Zellmer, David M Printzenhoff, Neil A Castle

Br J Pharmacol· July 2018

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Highly potent and selective Na1.7 inhibitors for use as intravenous agents and chemical probes.
R Ian Storer, Andy Pike, Nigel A Swain, Aristos J Alexandrou, Bruce M Bechle, David Printzenhoff

Bioorg Med Chem Lett· November 2017

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Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na1.7.
Nigel A Swain, Dave Batchelor, Serge Beaudoin, Bruce M Bechle, Paul A Bradley, David Printzenhoff

J Med Chem· August 2017

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Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells.
Zhixin Lin, Sonia Santos, Karen Padilla, David Printzenhoff, Neil A Castle

PLoS One· July 2017

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Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.
Aristos J Alexandrou, Adam R Brown, Mark L Chapman, Mark Estacion, Jamie Turner, David Printzenhoff

PLoS One· August 2016

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Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation.
Lingxin Wang, Shannon G Zellmer, David M Printzenhoff, Neil A Castle

Br J Pharmacol· October 2015

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A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability.
Claire Elizabeth Payne, Adam R Brown, Jonathon W Theile, Alexandre J C Loucif, Aristos J Alexandrou, David M Printzenhoff

Br J Pharmacol· May 2015

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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
Ken McCormack, Sonia Santos, Mark L Chapman, Douglas S Krafte, Brian E Marron, David Printzenhoff

Proc Natl Acad Sci U S A· July 2013

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Sodium channel inhibitor drug discovery using automated high throughput electrophysiology platforms.
Neil Castle, David Printzenhoff, Shannon Zellmer, Brett Antonio, Alan Wickenden

Comb Chem High Throughput Screen· January 2009

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In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892.
Murali Gopalakrishnan, Steven A Buckner, Char-Chang Shieh, Thomas Fey, Adebola Fabiyi, David Printzenhoff

Br J Pharmacol· September 2004

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Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K+ channel hKir2.3.
Yi Liu, Dong Liu, David Printzenhoff, Michael J Coghlan, Richard Harris

Eur J Pharmacol· January 2002

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