Publications by authors named "Neil Castle"

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Voltage sensor interaction site for a selective small molecule Nav1.1 sodium channel potentiator that enhances firing of fast-spiking interneurons.
Allison Gallucci, Franck Potet, Sonia Santos, Zhixin Lin, Jonathan Theile, Neil A Castle

Mol Pharmacol· October 2025

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A Model for Effective Learning in Competition: A Pedagogical Tool to Enhance Enjoyment and Perceptions of Competency in Physical Education Lessons for Young Children.
Neil Castle, Kristy Howells

Children (Basel)· January 2024

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Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough.
Rhianna E Lee, Catherine A Lewis, Lihua He, Emily C Bulik-Sullivan, Samuel C Gallant, Neil A Castle

J Clin Invest· September 2022

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PF-06526290 can both enhance and inhibit conduction through voltage-gated sodium channels.
Lingxin Wang, Shannon G Zellmer, David M Printzenhoff, Neil A Castle

Br J Pharmacol· July 2018

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GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K ) channel opener, reduces rat dorsal root ganglion neuron excitability.
Alexandre J C Loucif, Pierre-Philippe Saintot, Jia Liu, Brett M Antonio, Shannon G Zellmer, Neil A Castle

Br J Pharmacol· June 2018

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Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.
Matthew F Sammons, Sujay V Kharade, Kevin J Filipski, Markus Boehm, Aaron C Smith, Neil A Castle

ACS Med Chem Lett· February 2018

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Highly potent and selective Na1.7 inhibitors for use as intravenous agents and chemical probes.
R Ian Storer, Andy Pike, Nigel A Swain, Aristos J Alexandrou, Bruce M Bechle, Neil A Castle

Bioorg Med Chem Lett· November 2017

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Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells.
Zhixin Lin, Sonia Santos, Karen Padilla, David Printzenhoff, Neil A Castle

PLoS One· July 2017

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Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.
Aristos J Alexandrou, Adam R Brown, Mark L Chapman, Mark Estacion, Jamie Turner, Neil A Castle

PLoS One· August 2016

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Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation.
Lingxin Wang, Shannon G Zellmer, David M Printzenhoff, Neil A Castle

Br J Pharmacol· October 2015

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K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma.
Joanne Van Der Velden, Grace Sum, Donna Barker, Emmanuel Koumoundouros, Garry Barcham, Neil Castle

PLoS One· February 2014

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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
Ken McCormack, Sonia Santos, Mark L Chapman, Douglas S Krafte, Brian E Marron, Neil A Castle

Proc Natl Acad Sci U S A· July 2013

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Pharmacological modulation of voltage-gated potassium channels as a therapeutic strategy.
Neil A Castle

Expert Opin Ther Pat· November 2010

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Therapeutic potential of KCa3.1 blockers: recent advances and promising trends.
Heike Wulff, Neil A Castle

Expert Rev Clin Pharmacol· May 2010

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Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574).
Aaron C Gerlach, Sally J Stoehr, Neil A Castle

Mol Pharmacol· January 2010

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Voltage-gated potassium channels as therapeutic targets.
Heike Wulff, Neil A Castle, Luis A Pardo

Nat Rev Drug Discov· December 2009

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The effect of kappa-opioid receptor agonists on tetrodotoxin-resistant sodium channels in primary sensory neurons.
Xin Su, Neil A Castle, Brett Antonio, Rosemarie Roeloffs, James B Thomas

Anesth Analg· August 2009

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Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel.
Michael F Gross, Neil A Castle, Anruo Zou, Alan D Wickenden, Weifeng Yu

Bioorg Med Chem Lett· June 2009

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Sodium channel inhibitor drug discovery using automated high throughput electrophysiology platforms.
Neil Castle, David Printzenhoff, Shannon Zellmer, Brett Antonio, Alan Wickenden

Comb Chem High Throughput Screen· January 2009

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Aryl sulfonamido indane inhibitors of the Kv1.5 ion channel.
Michael F Gross, Serge Beaudoin, Grant McNaughton-Smith, George S Amato, Neil A Castle

Bioorg Med Chem Lett· May 2007

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Aquaporins as targets for drug discovery.
Neil A Castle

Drug Discov Today· April 2005

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In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892.
Murali Gopalakrishnan, Steven A Buckner, Char-Chang Shieh, Thomas Fey, Adebola Fabiyi, Neil A Castle

Br J Pharmacol· September 2004

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Electrophysiological analysis of heterologously expressed Kv and SK/IK potassium channels.
Neil A Castle, Alan D Wickenden, Anruo Zou

Curr Protoc Pharmacol· May 2003

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Structure-activity relationship of a novel class of naphthyl amide KATP channel openers.
Sean C Turner, William A Carroll, Tammie K White, Michael E Brune, Steven A Buckner, Neil A Castle

Bioorg Med Chem Lett· May 2003

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