Publications by authors named "David R Light"

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Selective AMPKβ1 activation induces fetal hemoglobin in human erythroid cells and sickle cell mice via the noncanonical NRF2 pathway.
Yannis Hara, Viktor T Lemgart, Samuel Lessard, Courtney J Mercadante, Jean-Antoine Ribeil, David R Light

Sci Adv· November 2025

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SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells.
Yannis Hara, Viktor T Lemgart, Nis Halland, Kiana Mahdaviani, Jean-Antoine Ribeil, David R Light

Blood Adv· June 2023

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MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease.
Melanie Demers, Sarah Sturtevant, Kevin R Guertin, Dipti Gupta, Kunal Desai, David R Light

Blood Adv· March 2021

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Can natural variation in erythroid microRNA-29b be translated to sickle cell disease severity?
David R Light

Br J Haematol· July 2019

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Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease.
Sriram Krishnamoorthy, Betty Pace, Dipti Gupta, Sarah Sturtevant, Biaoru Li, David R Light

JCI Insight· October 2017

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VLA-4 blockade by natalizumab inhibits sickle reticulocyte and leucocyte adhesion during simulated blood flow.
Jennell White, Sriram Krishnamoorthy, Dipti Gupta, Moira Lancelot, Nancy Moore, David R Light

Br J Haematol· September 2016

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FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes.
Arjan van der Flier, Zhan Liu, Siyuan Tan, Kai Chen, Douglas Drager, David R Light

PLoS One· January 2016

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Evaluation of the toxicology and pharmacokinetics of recombinant factor VIII Fc fusion protein in animals.
Jennifer A Dumont, Kenneth S Loveday, David R Light, Glenn F Pierce, Haiyan Jiang

Thromb Res· December 2015

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Evaluation of the toxicology, pharmacokinetics, and local tolerance of recombinant factor IX Fc fusion protein in animals.
Jennifer A Dumont, Kenneth S Loveday, David R Light, Glenn F Pierce, Haiyan Jiang

Thromb Res· August 2015

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In vivo biodistribution, PET imaging, and tumor accumulation of 86Y- and 111In-antimindin/RG-1, engineered antibody fragments in LNCaP tumor-bearing nude mice.
Douglas W Schneider, Tara Heitner, Bruno Alicke, David R Light, Kirk McLean

J Nucl Med· March 2009

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Development of a homogeneous time-resolved fluorescence leukotriene B4 assay for determining the activity of leukotriene A4 hydrolase.
Amy M Liang, Emmanuel Claret, Josy Ouled-Diaf, Alexandre Jean, David Vogel, David R Light

J Biomol Screen· June 2007

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A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) - part I: pharmacological characterization.
Yi-Xin Wang, Lei Zhao, Mariko Nagashima, Jon Vincelette, Drew Sukovich, David R Light

Thromb Haemost· January 2007

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Obligate multivalent recognition of cell surface tomoregulin following selection from a multivalent phage antibody library.
Tara Heitner, Noboru Satozawa, Kirk McLean, David Vogel, Ronald R Cobb, David R Light

J Biomol Screen· December 2006

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Amplified anticoagulant activity of tissue factor-targeted thrombomodulin: in-vivo validation of a tissue factor-neutralizing antibody fused to soluble thrombomodulin.
Yi-Xin Wang, Chenliang Wu, Jon Vincelette, Baby Martin-McNulty, Serene Alexander, David R Light

Thromb Haemost· September 2006

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Anti-EphA2 antibodies decrease EphA2 protein levels in murine CT26 colorectal and human MDA-231 breast tumors but do not inhibit tumor growth.
David Kiewlich, Jianhuan Zhang, Cynthia Gross, Wei Xia, Brent Larsen, David R Light

Neoplasia· January 2006

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The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex.
Jeffrey T Kohrt, Kevin J Filipski, Wayne L Cody, Cuiman Cai, Danette A Dudley, David R Light

Bioorg Med Chem Lett· November 2005

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Cloning and characterization of the rat HIF-1 alpha prolyl-4-hydroxylase-1 gene.
Ronald R Cobb, John McClary, Warren Manzana, Silke Finster, Brent Larsen, David R Light

Protein Expr Purif· August 2005

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Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors.
Brad O Buckman, Yuo-Ling Chou, Meg McCarrick, Amy Liang, Dao Lentz, David R Light

Bioorg Med Chem Lett· May 2005

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Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis.
Yi-Xin Wang, Baby Martin-McNulty, Valdeci da Cunha, Jon Vincelette, Xiangru Lu, David R Light

Circulation· May 2005

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Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.
Yi-Xin Wang, Valdeci da Cunha, Baby Martin-McNulty, Jon Vincelette, Weiwei Li, David R Light

Eur J Pharmacol· April 2005

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Conformation of a bound inhibitor of blood coagulant factor Xa.
Daniel R Studelska, Lynda M McDowell, Marc Adler, Robert D O'Connor, Anil K Mehta, David R Light

Biochemistry· July 2003

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Discovery and characterization of a potent and selective non-amidine inhibitor of human factor Xa.
Amy M Liang, David R Light, Monica Kochanny, Galina Rumennik, Lan Trinh

Biochem Pharmacol· May 2003

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Human factor Xa bound amidine inhibitor conformation by double rotational-echo double resonance nuclear magnetic resonance and molecular dynamics simulations.
Lynda M McDowell, Margaret A McCarrick, Daniel R Studelska, Robert D O'Connor, David R Light

J Med Chem· January 2003

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Crystal structures of two potent nonamidine inhibitors bound to factor Xa.
Marc Adler, Monica J Kochanny, Bin Ye, Galina Rumennik, David R Light

Biochemistry· December 2002

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Human in vitro pharmacodynamic profile of the selective Factor Xa inhibitor ZK-807834 (CI-1031).
Joseph M Post, Mark E Sullivan, Dana Abendschein, Janice Ewing, Josephine W Hinchman, David R Light

Thromb Res· February 2002

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