Publications by authors named "David Sabatini"

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Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2.
Martin S Taylor, Maggie Chen, Matthew Hancock, Maximilian Wranik, Bryant D Miller, David M Sabatini

Science· November 2025

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BoltzGen: Toward Universal Binder Design.
Hannes Stark, Felix Faltings, MinGyu Choi, Yuxin Xie, Eunsu Hur, David M Sabatini

bioRxiv· November 2025

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Structural basis for the dynamic regulation of mTORC1 by amino acids.
Max L Valenstein, Maximilian Wranik, Pranav V Lalgudi, Karen Y Linde-Garelli, Yuri Choi, David M Sabatini

Nature· October 2025

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Lysosomal reduced thiols are essential for mouse embryonic development.
Charles H Adelmann, Avanthika Venkatachalam, Lingjuan Huang, Michelle Liu, Sharon Germana, David M Sabatini

Proc Natl Acad Sci U S A· September 2025

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Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation.
G Jordan Ray, Eleonora Nardini, Heather R Keys, Daniel H Lin, David M Sabatini

bioRxiv· September 2025

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Atlas of Lysosomal Aging Reveals a Molecular Clock of Storage Disorder-Associated Metabolites.
Anna M Puszynska, Thao P Nguyen, Andrew L Cangelosi, Andrea Armani, Justin M Roberts, David M Sabatini

bioRxiv· September 2025

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Technologies for Decoding Cancer Metabolism with Spatial Resolution.
Walter W Chen, Michael E Pacold, David M Sabatini, Naama Kanarek

Cold Spring Harb Perspect Med· July 2025

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Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders.
Jason Yang, Yunhan Xu, David R Ziehr, Martin S Taylor, Max L Valenstein, David M Sabatini

Science· July 2025

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Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST.
Hans-Georg Sprenger, Melanie J Mittenbühler, Yizhi Sun, Jonathan G Van Vranken, Sebastian Schindler, David M Sabatini

Cell Metab· April 2025

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Rhodoquinone carries electrons in the mammalian electron transport chain.
Jonathan Valeros, Madison Jerome, Tenzin Tseyang, Paula Vo, Thang Do, David M Sabatini

Cell· February 2025

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Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation.
Max L Valenstein, Pranav V Lalgudi, Jibril F Kedir, Kendall J Condon, Anna Platzek, David M Sabatini

Nature· January 2025

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SLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation.
Izabella A Pena, Jeffrey S Shi, Sarah M Chang, Jason Yang, Samuel Block, David M Sabatini

Nat Commun· January 2025

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Lysosomal reduced thiols are essential for mouse embryonic development.
Charles H Adelmann, Avanthika Venkatachalam, Lingjuan Huang, Michelle Liu, Sharon Germana, David M Sabatini

bioRxiv· December 2024

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Reach-dependent reorientation of rotational dynamics in motor cortex.
David A Sabatini, Matthew T Kaufman

Nat Commun· August 2024

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Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway.
Max L Valenstein, Pranav V Lalgudi, Xin Gu, Jibril F Kedir, Martin S Taylor, David M Sabatini

Proc Natl Acad Sci U S A· August 2024

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CSMD1 regulates brain complement activity and circuit development.
Matthew L Baum, Daniel K Wilton, Rachel G Fox, Alanna Carey, Yu-Han H Hsu, David A Sabatini

Brain Behav Immun· July 2024

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Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST.
Hans-Georg Sprenger, Melanie J Mittenbühler, Yizhi Sun, Jonathan G Van Vranken, Sebastian Schindler, David M Sabatini

bioRxiv· April 2024

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Not all information is informative: An exploration of educational content on recycled potable water knowledge and acceptance.
Braden Tanner, Portia McDonald, Dana Mahmoud-Elhaj, David Sabatini, Jim F Chamberlain

Water Res· March 2024

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An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway.
Grace Y Liu, Patrick Jouandin, Raymond E Bahng, Norbert Perrimon, David M Sabatini

Nat Commun· March 2024

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Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity.
Yong Yu, Shihong M Gao, Youchen Guan, Pei-Wen Hu, Qinghao Zhang, David M Sabatini

Elife· January 2024

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An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway.
Grace Y Liu, Patrick Jouandin, Raymond E Bahng, Norbert Perrimon, David M Sabatini

bioRxiv· May 2023

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Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction.
Jacob M Winter, Heidi L Fresenius, Corey N Cunningham, Peng Wei, Heather R Keys, David M Sabatini

Elife· November 2022

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Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.
Xin Gu, Patrick Jouandin, Pranav V Lalgudi, Rich Binari, Max L Valenstein, David M Sabatini

Nature· September 2022

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Author Correction: NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis.
Samantha W Alvarez, Vladislav O Sviderskiy, Erdem M Terzi, Thales Papagiannakopoulos, Andre L Moreira, David M Sabatini

Nature· September 2022

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CLN3 is required for the clearance of glycerophosphodiesters from lysosomes.
Nouf N Laqtom, Wentao Dong, Uche N Medoh, Andrew L Cangelosi, Vimisha Dharamdasani, David M Sabatini

Nature· September 2022

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