Publications by authors named "David Sinclair"

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Economic burden of heart failure in Europe: A systematic review of costs and cost-effectiveness.
Josep Darbà, Meritxell Ascanio, Antonio Rodríguez, Sarah J Charman, Nduka C Okwose, David R Sinclair

ESC Heart Fail· December 2025

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Disparities in the use of remote general practice consultations: learning from the COVID-19 pandemic, an analysis of 19 million electronic health records using OpenSAFELY.
Abodunrin Q Aminu, David R Sinclair, Katie Davies, Alex Hall, Milan Wiedemann

BMC Med· December 2025

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The association between multiple long-term conditions and dementia: A UK cohort study.
Hilary Shepherd, Adam Todd, David R Sinclair, Charlotte L Richardson, Fiona E Matthews

Alzheimers Dement (Amst)· December 2025

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Are participants with disability referred for social prescribing? Findings from the English Longitudinal Study of Ageing.
Laurie E Davies, David R Sinclair, Angel Osei, Andrew Kingston, Mark Adley

J Public Health (Oxf)· November 2025

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The conceptualisation and measurement of social frailty in older people: an umbrella review.
Martin Webber, Beth Casey, Laura Tucker, Kirsty Shires, Mark Wilberforce, David Sinclair

J Frailty Aging· October 2025

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Multiomic clocks to predict phenotypic age in mice.
Daniel L Vera, Patrick T Griffin, David Leigh, Jason Kras, Enrique Ramos, David A Sinclair

J Gerontol A Biol Sci Med Sci· October 2025

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Associations Between Frailty and Cognitive Outcomes Across the Lifespan of Mice.
Sydney Bartman, Lauren Gaspar, Alice Kane, Emily Potts, David A Sinclair

bioRxiv· October 2025

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DNA Break-Induced Epigenetic Alterations Promote Plaque Formation and Behavioral Deficits in an Alzheimer's Disease Mouse Model.
Sydney Bartman, Dakota Hunter, Lauren Gaspar, Hannah Tobias-Wallingford, Danielo Zamor, David A Sinclair

bioRxiv· October 2025

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Single-Short Partial Reprogramming of the Endothelial Cells Decreases Blood Pressure via Attenuation of EndMT in Hypertensive Mice.
Laena Pernomian, Emily W Waigi, Vi Nguyen, Ahmed D Mohammed, Tiago J Costa, David A Sinclair

Circ Res· September 2025

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Emerging strategies, applications and challenges of targeting NAD in the clinic.
Jianying Zhang, He-Ling Wang, Sofie Lautrup, Hilde Loge Nilsen, Jonas T Treebak, David A Sinclair

Nat Aging· September 2025

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Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision.
Yuancheng Ryan Lu, James C Cameron, Yan Hu, Han Shen, Shintaro Shirahama, David A Sinclair

bioRxiv· September 2025

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Frailty-free life expectancy and its association with socio-economic characteristics: an analysis of the English Longitudinal Study of Ageing cohort study.
David R Sinclair, Asri Maharani, Andrew Kingston, Terence W O'Neill, Fiona E Matthews

BMC Med· May 2025

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Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice.
Dantong Zhu, Judy Z Wu, Patrick T Griffin, Brady A Samuelson, David A Sinclair

NPJ Aging· May 2025

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Multiomic clocks to predict phenotypic age in mice.
Daniel L Vera, Patrick T Griffin, David Leigh, Jason Kras, Enrique Ramos, David A Sinclair

bioRxiv· May 2025

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Differences in the risk of frailty based on care receipt, unmet care needs and socio-economic inequalities: A longitudinal analysis of the English Longitudinal Study of Ageing.
David R Sinclair, Asri Maharani, Andrew Clegg, Barbara Hanratty, Gindo Tampubolon

J Frailty Aging· April 2025

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Area-level socioeconomic inequalities in activities of daily living disability-free life expectancy in England: a modelling study.
Laurie E Davies, David R Sinclair, Christopher Todd, Barbara Hanratty, Fiona E Matthews

Lancet Healthy Longev· April 2025

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Invigorating discovery and clinical translation of aging biomarkers.
Erik Jacques, Chiara Herzog, Kejun Ying, Alan Tomusiak, Jessica Kasamoto, David A Sinclair

Nat Aging· April 2025

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Organising general practice for care homes: a multi-method study.
Barbara Hanratty, Rachel Stocker, David Sinclair, Katie Brittain, Karen Spilsbury

Health Soc Care Deliv Res· April 2025

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Cellular rejuvenation protects neurons from inflammation-mediated cell death.
Sienna S Drake, Abdulshakour Mohammadnia, Aliyah Zaman, Christine Gianfelice, Kali Heale, David A Sinclair

Cell Rep· February 2025

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Understanding polypharmacy for people receiving home care services: a scoping review of the evidence.
Radin Karimi, Anna Robinson-Barella, Vanessa Davey, David R Sinclair, Barbara Hanratty

Age Ageing· February 2025

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iSurgARy: A mobile augmented reality solution for ventriculostomy in resource-limited settings.
Zahra Asadi, Joshua Pardillo Castillo, Mehrdad Asadi, David S Sinclair, Marta Kersten-Oertel

Healthc Technol Lett· January 2025

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Ecological study of the association between the English national vaccination programme and area deprivation inequalities in COVID-19 mortality.
Natalie Bennett, Clare Bambra, David Sinclair, Adam Todd, Fiona Matthews

BMJ Open· January 2025

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Which unmet social care needs have the biggest impact on healthy ageing? An analysis of data from the English Longitudinal Study of Ageing.
Gemma F Spiers, Laurie E Davies, David Sinclair, Michelle M C Tan, Andrew Kingston

BMJ Open· January 2025

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Inequalities at Age of Diagnosis of Severe Mental Illness in England.
Sheena E Ramsay, Ziyi Cai, David R Sinclair, Matthew Prina, David P J Osborn

JAMA Netw Open· January 2025

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Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice.
Dantong Zhu, Judy Z Wu, Patrick Griffin, Brady A Samuelson, David A Sinclair

bioRxiv· January 2025

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