Publications by authors named "David Spaner"

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High-content imaging of primary chronic lymphocytic leukemia cells predicts patient cohorts with distinct cellular drug responses.
Mark X Li, Glauber C Brito, Jarkko Ylanko, Alla Buzina, Brian Leber, David E Spaner

iScience· December 2025

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Effect of statins on IL-10 signaling and production by chronic lymphocytic leukemia cells.
Guizhi Wang, Tina YuXuan Luo, Yonghong Shi, Aditya Surya, Haggag S Zein, David E Spaner

J Immunol· September 2025

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Effect of Statins in the Watch and Wait Phase of Chronic Lymphocytic Leukemia.
David E Spaner

Cancer Med· April 2025

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ISGylation enhances dsRNA-induced interferon response and NFκB signaling in fallopian tube epithelial cells.
Vidushi Madaan, Alexandra Kollara, David Spaner, Theodore J Brown

J Biol Chem· September 2024

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IL-1 receptor antagonism reveals a yin-yang relationship between NFκB and interferon signaling in chronic lymphocytic leukemia.
YuXuan Luo, BoYang Su, Vincent Hung, YuHan Luo, Yonghong Shi, David E Spaner

Proc Natl Acad Sci U S A· August 2024

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Paradoxical activation of chronic lymphocytic leukemia cells by ruxolitinib and .
David E Spaner, Tina YuXuan Luo, Guizhi Wang, Gideon Schreiber, Daniel Harari

Front Oncol· April 2023

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Enhanced IFN Sensing by Aggressive Chronic Lymphocytic Leukemia Cells.
Tina YuXuan Luo, Yonghong Shi, Guizhi Wang, David E Spaner

J Immunol· November 2022

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O-GlcNAcylation in Chronic Lymphocytic Leukemia and Other Blood Cancers.
David E Spaner

Front Immunol· February 2022

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Janus kinases restrain chronic lymphocytic leukemia cells in patients on ibrutinib: Results of a phase II trial.
David E Spaner, Yuxuan Luo, Guizhei Wang, Jennifer Gallagher, Hubert Tsui

Cancer Med· December 2021

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Effect of Ibrutinib on the IFN Response of Chronic Lymphocytic Leukemia Cells.
Meihui Xia, Tina Yuxuan Luo, Yonghong Shi, Guizhi Wang, Hubert Tsui, David E Spaner

J Immunol· November 2020

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Ibrutinib reprograms the glucocorticoid receptor in chronic lymphocytic leukemia cells.
Yonghong Shi, Guizhi Wang, Elizabeth M Muhowski, Lindsay McCaw, Catherine Wang, David E Spaner

Leukemia· July 2019

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A phase 2 study of lenalidomide and dexamethasone in previously untreated patients with chronic lymphocytic leukemia (CLL).
Christine I Chen, Harminder Paul, Susi Snitzler, Sumeet Kakar, Lisa W Le, David Spaner

Leuk Lymphoma· April 2019

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A phase I study of romidepsin, gemcitabine, dexamethasone and cisplatin combination therapy in the treatment of peripheral T-cell and diffuse large B-cell lymphoma; the Canadian cancer trials group LY.15 study†.
Tony Reiman, Kerry J Savage, Michael Crump, Matthew C Cheung, David MacDonald, David Spaner

Leuk Lymphoma· April 2019

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Persistent janus kinase-signaling in chronic lymphocytic leukemia patients on ibrutinib: Results of a phase I trial.
David E Spaner, Lindsay McCaw, Guizhei Wang, Hubert Tsui, Yonghong Shi

Cancer Med· April 2019

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Autologous stem cell transplant and combination immunotherapy of rituximab and interferon-α induces prolonged clinical and molecular remissions in patients with follicular lymphoma.
Liam Smyth, Rena Buckstein, Nancy Pennell, Rashmi Weerasinghe, Matthew C Cheung, David Spaner

Br J Haematol· February 2019

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Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis.
Tangjingjun Liu, Lei Xia, Yao Yao, Chen Yan, Yanhua Fan, David E Spaner

Cell Death Dis· February 2019

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Novel flavagline-like compounds with potent Fli-1 inhibitory activity suppress diverse types of leukemia.
Jialei Song, Chunmao Yuan, Jue Yang, Tangjingjun Liu, Yao Yao, David Spaner

FEBS J· December 2018

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Peroxisome Proliferator-Activated Receptor-δ Supports the Metabolic Requirements of Cell Growth in TCRβ-Selected Thymocytes and Peripheral CD4 T Cells.
Fei Linda Zhao, Jeeyoon Jennifer Ahn, Edward L Y Chen, Tae Joon Yi, Natalie H Stickle, David Spaner

J Immunol· November 2018

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Association of blood IgG with tumor necrosis factor-alpha and clinical course of chronic lymphocytic leukemia.
David E Spaner, Robertson Venema, Justin Huang, Peter Norris, Alan Lazarus

EBioMedicine· September 2018

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An autologous tumor vaccine for CLL.
Fang Zhu, Ismat Khatri, David Spaner, Reginald M Gorczynski

Leuk Res· May 2018

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Targeting the IL-17/IL-6 axis can alter growth of Chronic Lymphocytic Leukemia in vivo/in vitro.
Fang Zhu, Lindsay McCaw, David E Spaner, Reginald M Gorczynski

Leuk Res· March 2018

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Response.
Lee Mozessohn, Craig C Earle, David Spaner, Stephanie Y Cheng, Matthew Kumar

J Natl Cancer Inst· April 2017

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The Association of Dyslipidemia With Chronic Lymphocytic Leukemia: A Population-Based Study.
Lee Mozessohn, Craig Earle, David Spaner, Stephanie Y Cheng, Matthew Kumar

J Natl Cancer Inst· March 2017

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Low Density Lipoproteins Amplify Cytokine-signaling in Chronic Lymphocytic Leukemia Cells.
Lindsay McCaw, Yonghong Shi, Guizhi Wang, You-Jun Li, David E Spaner

EBioMedicine· February 2017

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Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells.
Sina Oppermann, Avery J Lam, Stephanie Tung, Yonghong Shi, Lindsay McCaw, David E Spaner

Oncotarget· November 2016

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