Publications by authors named "David T Weaver"

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Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Xenograft Model.
Shih-Shih Chen, Jacqueline C Barrientos, Gerardo Ferrer, Morgan King-Richards, Yu-Ju Chen, David T Weaver

Clin Cancer Res· May 2023

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Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib.
Kathleen J Till, Mariah Abdullah, Tahera Alnassfan, Gallardo Zapata Janet, Thomas Marks, David T Weaver

Sci Rep· March 2023

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Combinatorial Inhibition of Focal Adhesion Kinase and BCL-2 Enhances Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia.
Xiangmeng Wang, Po Yee Mak, Hong Mu, Wenjing Tao, Arvind Rao, David T Weaver

Mol Cancer Ther· August 2020

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Efficacy and Safety of Duvelisib Following Disease Progression on Ofatumumab in Patients with Relapsed/Refractory CLL or SLL in the DUO Crossover Extension Study.
Matthew S Davids, Bryone J Kuss, Peter Hillmen, Marco Montillo, Carol Moreno, David T Weaver

Clin Cancer Res· May 2020

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Phase 2 study of the focal adhesion kinase inhibitor defactinib (VS-6063) in previously treated advanced KRAS mutant non-small cell lung cancer.
David E Gerber, D Ross Camidge, Daniel Morgensztern, Jeremey Cetnar, Ronan J Kelly, David T Weaver

Lung Cancer· January 2020

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FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.
Carlos J Diaz Osterman, Duygu Ozmadenci, Elizabeth G Kleinschmidt, Kristin N Taylor, Allison M Barrie, David T Weaver

Elife· September 2019

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PYK2/FAK inhibitors reverse hypoxia-induced drug resistance in multiple myeloma.
Barbara Muz, Maurizio Buggio, Feda Azab, Pilar de la Puente, Mark Fiala, David T Weaver

Haematologica· July 2019

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DYNAMO: A Phase II Study of Duvelisib (IPI-145) in Patients With Refractory Indolent Non-Hodgkin Lymphoma.
Ian W Flinn, Carole B Miller, Kirit M Ardeshna, Scott Tetreault, Sarit E Assouline, David T Weaver

J Clin Oncol· April 2019

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Maintenance Defactinib Versus Placebo After First-Line Chemotherapy in Patients With Merlin-Stratified Pleural Mesothelioma: COMMAND-A Double-Blind, Randomized, Phase II Study.
Dean A Fennell, Paul Baas, Paul Taylor, Anna K Nowak, David Gilligan, David T Weaver

J Clin Oncol· April 2019

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The phase 3 DUO trial: duvelisib vs ofatumumab in relapsed and refractory CLL/SLL.
Ian W Flinn, Peter Hillmen, Marco Montillo, Zsolt Nagy, Árpád Illés, David T Weaver

Blood· December 2018

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Inactivation of deubiquitinase CYLD enhances therapeutic antibody production in Chinese hamster ovary cells.
Yafang Lu, Qin Zhou, Qianqian Han, Pengfei Wu, Lanlan Zhang, David T Weaver

Appl Microbiol Biotechnol· July 2018

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The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma.
Asma Begum, Theodore Ewachiw, Clinton Jung, Ally Huang, K Jessica Norberg, David T Weaver

PLoS One· September 2017

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Inhibition of FAK kinase activity preferentially targets cancer stem cells.
Vihren N Kolev, Winnie F Tam, Quentin G Wright, Sean P McDermott, Christian M Vidal, David T Weaver

Oncotarget· August 2017

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Characterization of an Lrp/AsnC family regulator SCO3361, controlling actinorhodin production and morphological development in Streptomyces coelicolor.
Jing Liu, Jie Li, Hong Dong, Yunfu Chen, Yansheng Wang, David T Weaver

Appl Microbiol Biotechnol· July 2017

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Focal Adhesion Kinase as a Potential Target in AML and MDS.
Bing Z Carter, Po Yee Mak, Xiangmeng Wang, Hui Yang, Guillermo Garcia-Manero, David T Weaver

Mol Cancer Ther· June 2017

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Engineering of an Lrp family regulator SACE_Lrp improves erythromycin production in Saccharopolyspora erythraea.
Jing Liu, Yunfu Chen, Weiwei Wang, Min Ren, Panpan Wu, David T Weaver

Metab Eng· January 2017

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Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.
Hong Jiang, Samarth Hegde, Brett L Knolhoff, Yu Zhu, John M Herndon, David T Weaver

Nat Med· August 2016

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Synergism of FAK and tyrosine kinase inhibition in Ph B-ALL.
Michelle L Churchman, Kathryn Evans, Jennifer Richmond, Alissa Robbins, Luke Jones, David T Weaver

JCI Insight· April 2016

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In vivo investigation to the macrolide-glycosylating enzyme pair DesVII/DesVIII in Saccharopolyspora erythraea.
Hang Wu, Weiwei Li, Chen Xin, Congming Zhang, Yansheng Wang, David T Weaver

Appl Microbiol Biotechnol· March 2016

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Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in .
Hang Wu, Yansheng Wang, Li Yuan, Yongrong Mao, Weiwei Wang, David T Weaver

Synth Syst Biotechnol· March 2016

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DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer.
Tanguy Y Seiwert, XiaoZhe Wang, Jana Heitmann, Vivian Villegas-Bergazzi, Kam Sprott, David T Weaver

PLoS One· November 2015

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Capturing the target genes of BldD in Saccharopolyspora erythraea using improved genomic SELEX method.
Hang Wu, Yongrong Mao, Meng Chen, Hui Pan, Xunduan Huang, David T Weaver

Appl Microbiol Biotechnol· March 2015

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c-Abl regulates proteasome abundance by controlling the ubiquitin-proteasomal degradation of PSMA7 subunit.
Dapei Li, Qincai Dong, Qingping Tao, Jing Gu, Yan Cui, David T Weaver

Cell Rep· February 2015

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PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells.
Vihren N Kolev, Quentin G Wright, Christian M Vidal, Jennifer E Ring, Irina M Shapiro, David T Weaver

Cancer Res· January 2015

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Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraea.
Hang Wu, Meng Chen, Yongrong Mao, Weiwei Li, Jingtao Liu, David T Weaver

Microb Cell Fact· November 2014

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