Publications by authors named "David Toft"

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Phase I study of tanespimycin in combination with bortezomib in patients with advanced solid malignancies.
Erin Schenk, Andrea E Wahner Hendrickson, Donald Northfelt, David O Toft, Matthew M Ames

Invest New Drugs· October 2013

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Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumors.
Joleen Hubbard, Charles Erlichman, David O Toft, Rui Qin, Bridget A Stensgard

Invest New Drugs· June 2011

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Characterization of plant p23-like proteins for their co-chaperone activities.
Zhongming Zhang, William Sullivan, Sara J Felts, Bishun D Prasad, David O Toft

Cell Stress Chaperones· September 2010

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FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells.
Li Ni, Chun-Song Yang, Daniel Gioeli, Henry Frierson, David O Toft

Mol Cell Biol· March 2010

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Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions.
David F Smith, David O Toft

Mol Endocrinol· October 2008

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Cisplatin abrogates the geldanamycin-induced heat shock response.
Andrea K McCollum, Kara B Lukasiewicz, Cynthia J Teneyck, Wilma L Lingle, David O Toft

Mol Cancer Ther· October 2008

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P-Glycoprotein-mediated resistance to Hsp90-directed therapy is eclipsed by the heat shock response.
Andrea K McCollum, Cynthia J TenEyck, Bridget Stensgard, Bruce W Morlan, Karla V Ballman, David O Toft

Cancer Res· September 2008

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Role of the cochaperone Tpr2 in Hsp90 chaperoning.
Nela S Cintrón Moffatt, Elizabeth Bruinsma, Cindy Uhl, Wolfgang M J Obermann, David Toft

Biochemistry· August 2008

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GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity.
Ahmed Chadli, Sara J Felts, David O Toft

J Biol Chem· April 2008

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Analysis of Hsp90 cochaperone interactions reveals a novel mechanism for TPR protein recognition.
Ahmed Chadli, Elizabeth S Bruinsma, Bridget Stensgard, David Toft

Biochemistry· March 2008

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Functioning of the Hsp90 machine in chaperoning checkpoint kinase I (Chk1) and the progesterone receptor (PR).
Sara J Felts, Larry M Karnitz, David O Toft

Cell Stress Chaperones· March 2008

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An acetylation site in the middle domain of Hsp90 regulates chaperone function.
Bradley T Scroggins, Kenneth Robzyk, Dongxia Wang, Monica G Marcu, Shinji Tsutsumi, David Toft

Mol Cell· January 2007

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Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism.
Andrea K McCollum, Cynthia J Teneyck, Brian M Sauer, David O Toft, Charles Erlichman

Cancer Res· November 2006

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A phase I trial of twice-weekly 17-allylamino-demethoxy-geldanamycin in patients with advanced cancer.
Grzegorz S Nowakowski, Andrea K McCollum, Matthew M Ames, Sumithra J Mandrekar, Joel M Reid, David O Toft

Clin Cancer Res· October 2006

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Defining the requirements for Hsp40 and Hsp70 in the Hsp90 chaperone pathway.
Nela S Cintron, David Toft

J Biol Chem· September 2006

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GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.
Ahmed Chadli, J Dinny Graham, M Greg Abel, Twila A Jackson, David F Gordon, David Toft

Mol Cell Biol· March 2006

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Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones.
Sonnet J H Arlander, Sara J Felts, Jill M Wagner, Bridget Stensgard, David O Toft

J Biol Chem· February 2006

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HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.
Jeffrey J Kovacs, Patrick J M Murphy, Stéphanie Gaillard, Xuan Zhao, June-Tai Wu, David O Toft

Mol Cell· May 2005

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Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding.
Qing Huai, Huanchen Wang, Yudong Liu, Hwa-Young Kim, David Toft

Structure· April 2005

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Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70.
Amerigo Carrello, Rudi K Allan, Sarah L Morgan, Barbara A L Owen, Danny Mok, David O Toft

Cell Stress Chaperones· February 2005

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Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer.
Matthew P Goetz, David Toft, Joel Reid, Matthew Ames, Bridget Stensgard

J Clin Oncol· February 2005

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Requirement of heat shock protein 90 for human hepatitis B virus reverse transcriptase function.
Jianming Hu, Dafna Flores, David Toft, Xingtai Wang, David Nguyen

J Virol· December 2004

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Hsp90: from structure to phenotype.
Sophie E Jackson, Christine Queitsch, David Toft

Nat Struct Mol Biol· December 2004

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A novel in situ assay for the identification and characterization of soluble nuclear mobility factors.
Cem Elbi, Dawn A Walker, Marcia Lewis, Guillermo Romero, William P Sullivan, David O Toft

Sci STKE· June 2004

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Molecular chaperones function as steroid receptor nuclear mobility factors.
Cem Elbi, Dawn A Walker, Guillermo Romero, William P Sullivan, David O Toft

Proc Natl Acad Sci U S A· March 2004

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