Publications by authors named "David Tweats"

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Chemically induced aneuploidy in germ cells. Part II of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.
Francesca Pacchierotti, Kenichi Masumura, David A Eastmond, Azeddine Elhajouji, Roland Froetschl, David Tweats

Mutat Res Genet Toxicol Environ Mutagen· December 2019

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Targets and mechanisms of chemically induced aneuploidy. Part 1 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.
Anthony M Lynch, David Eastmond, Azeddine Elhajouji, Roland Froetschl, Micheline Kirsch-Volders, David Tweats

Mutat Res Genet Toxicol Environ Mutagen· November 2019

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Role of aneuploidy in the carcinogenic process: Part 3 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.
David Tweats, David A Eastmond, Anthony M Lynch, Azeddine Elhajouji, Roland Froetschl

Mutat Res Genet Toxicol Environ Mutagen· November 2019

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Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity.
David J Tweats, George E Johnson, Ivan Scandale, James Whitwell, Dean B Evans

Mutagenesis· September 2018

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Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity.
David J Tweats, George E Johnson, Ivan Scandale, James Whitwell, Dean B Evans

Mutagenesis· May 2016

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Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness).
David Tweats, Bernadette Bourdin Trunz, Els Torreele

Mutagenesis· September 2012

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1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.
Bernadette Bourdin Trunz, Rafał Jędrysiak, David Tweats, Reto Brun, Marcel Kaiser

Eur J Med Chem· May 2011

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Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.
Els Torreele, Bernadette Bourdin Trunz, David Tweats, Marcel Kaiser, Reto Brun

PLoS Negl Trop Dis· December 2010

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The Viracept-EMS case: impact and outlook.
Vernon E Walker, Daniel A Casciano, David J Tweats

Toxicol Lett· November 2009

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Practical issues on the application of the GHS classification criteria for germ cell mutagens.
Takeshi Morita, Makoto Hayashi, Madoka Nakajima, Noriho Tanaka, David J Tweats

Regul Toxicol Pharmacol· October 2009

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Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.
Anton Pozniak, Lutz Müller, Miklos Salgo, Judith K Jones, Peter Larson, David Tweats

AIDS Res Ther· August 2009

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Omic profiling for drug safety assessment: current trends and public-private partnerships.
William M Gallagher, David Tweats, Jochen Koenig

Drug Discov Today· April 2009

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Interlaboratory assessment of the GreenScreen HC GADD45a-GFP genotoxicity screening assay: an enabling study for independent validation as an alternative method.
Nicholas Billinton, Paul W Hastwell, Dominiek Beerens, Louise Birrell, Patricia Ellis, David J Tweats

Mutat Res· May 2008

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How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.
David Kirkland, Stefan Pfuhler, David Tweats, Marilyn Aardema, Raffaella Corvi

Mutat Res· March 2007

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Joint EFPIA/CHMP SWP workshop: the Emerging Use of Omic Technologies for Regulatory Non-Clinical Safety Testing.
Peter Kasper, Gerry Oliver, Beatriz Silva Lima, Thomas Singer, David Tweats

Pharmacogenomics· March 2005

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Strategy for genotoxicity testing and stratification of genotoxicity test results--report on initial activities of the IWGT Expert Group.
Lutz Müller, David Blakey, Kerry L Dearfield, Sheila Galloway, Peggy Guzzie, David Tweats

Mutat Res· October 2003

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