Publications by authors named "David Virley"

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Behavioral and transcriptomic effects of a novel cannabinoid on a rat valproic acid model of autism.
Sally Loomis, Diogo G Silva, Ranjev Savopoulos, Jackie Cilia, Jennifer Li, David Virley

Neuropharmacology· August 2025

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Acute cannabidiol (CBD), tetrahydrocannabinol (THC) and their mixture (THC:CBD) exert differential effects on brain activity and blood flow in rats: A translational neuroimaging study.
Eilidh MacNicol, Michelle Kokkinou, Maria Elisa Serrano Navacerrada, Donna-Michelle Smith, Jennifer Li, David Virley

J Psychopharmacol· August 2025

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Nabiximols (NBX) suppresses tremor in a rat Harmaline model of essential tremor.
Sally Loomis, Elena Samoylenko, David Virley, Andrew C McCreary

Exp Neurol· December 2024

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Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities.
David Cabañero, Takeshi Irie, Marta Celorrio, Christopher Trousdale, David M Owens, David Virley

Pain Rep· September 2016

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Nonhuman primates: translational models for predicting antipsychotic-induced movement disorders.
Roger D Porsolt, Vincent Castagné, Eric Hayes, David Virley

J Pharmacol Exp Ther· December 2013

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The age-related gliosis and accompanying deficit in spatial learning are unaffected by dimebon.
Thelma R Cowley, Rodrigo Esteban González-Reyes, Jill C Richardson, David Virley, Neil Upton

Neurochem Res· June 2013

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Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457.
Charlotte K Callaghan, Vincent Hok, Andrea Della-Chiesa, David J Virley, Neil Upton

Neuropharmacology· October 2012

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Differential behavioral profiling of stimulant substances in the rat using the LABORAS™ system.
Vincent Castagné, Toni Wolinsky, Leann Quinn, David Virley

Pharmacol Biochem Behav· June 2012

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The neuroprotective effect of a specific P2X₇ receptor antagonist derives from its ability to inhibit assembly of the NLRP3 inflammasome in glial cells.
Niamh Murphy, Thelma R Cowley, Jill C Richardson, David Virley, Neil Upton

Brain Pathol· May 2012

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Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats.
Boon Wan Wang, Vincent Hok, Andrea Della-Chiesa, Charlotte Callaghan, Sally Barlow, David J Virley

Neurobiol Aging· April 2012

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Effects of the selective 5-HT(7) receptor antagonist SB-269970 in animal models of psychosis and cognition.
Kerry A Waters, Tania O Stean, Beverley Hammond, David J Virley, Neil Upton

Behav Brain Res· March 2012

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Activation of α7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Aß-mediated inhibition of LTP in the rat hippocampus.
Tomas Ondrejcak, Qinwen Wang, James N C Kew, David J Virley, Neil Upton

Eur J Pharmacol· February 2012

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Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP.
Thelma R Cowley, Joan O'Sullivan, Christoph Blau, Brian F Deighan, Raasay Jones, David Virley

Neurobiol Aging· January 2012

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Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist.
Mairi Sime, Amanda C Allan, Paul Chapman, Charlotte Fieldhouse, Gerard M P Giblin, David J Virley

Bioorg Med Chem Lett· September 2011

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Dietary manipulation and caloric restriction in the development of mouse models relevant to neurological diseases.
Joern E Schroeder, Jill C Richardson, David J Virley

Biochim Biophys Acta· October 2010

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The thiazolidinedione pioglitazone increases cholesterol biosynthetic gene expression in primary cortical neurons by a PPARgamma-independent mechanism.
Graham Cocks, Jonathan I Wilde, Simon J Graham, Vicky Bousgouni, David Virley

J Alzheimers Dis· April 2010

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Autoradiographical imaging of PPARgamma agonist effects on PBR/TSPO binding in TASTPM mice.
Jennifer C Roberts, Sarah L Friel, Shilina Roman, Marion Perren, Alex Harper, David Virley

Exp Neurol· April 2009

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5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease.
Neil Upton, Tsu Tshen Chuang, Ann J Hunter, David J Virley

Neurotherapeutics· July 2008

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A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl.
Leann P Quinn, Marion J Perren, Kim T Brackenborough, Peter L Woodhams, Martin Vidgeon-Hart, David J Virley

J Neurosci Methods· August 2007

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Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex.
Anthony J Strong, Peter J Anderson, Helena R Watts, David J Virley, Andrew Lloyd

Brain· April 2007

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Rosiglitazone induces mitochondrial biogenesis in mouse brain.
Jay C Strum, Ron Shehee, David Virley, Jill Richardson, Michael Mattie

J Alzheimers Dis· March 2007

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Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.
Perdita L Pugh, Martin P Vidgeon-Hart, Tracey Ashmeade, Ainsley A Culbert, Zoe Seymour, David J Virley

J Neuroinflammation· February 2007

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Further validation of LABORAS using various dopaminergic manipulations in mice including MPTP-induced nigro-striatal degeneration.
Leann P Quinn, Tania O Stean, Helen Chapman, Matthew Brown, Martin Vidgeon-Hart, David J Virley

J Neurosci Methods· September 2006

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Developing therapeutics for the treatment of multiple sclerosis.
David J Virley

NeuroRx· October 2005

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Identification of neuroprotective properties of anti-MAG antibody: a novel approach for the treatment of stroke?
Elaine A Irving, Mary Vinson, Claudia Rosin, Jenny C Roberts, Debra M Chapman, David J Virley

J Cereb Blood Flow Metab· January 2005

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