Publications by authors named "Jay C Strum"

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CDK4/6 inhibition enhances antitumor efficacy of chemotherapy and immune checkpoint inhibitor combinations in preclinical models and enhances T-cell activation in patients with SCLC receiving chemotherapy.
Anne Y Lai, Jessica A Sorrentino, Konstantin H Dragnev, Jared M Weiss, Taofeek K Owonikoko, Jay C Strum

J Immunother Cancer· October 2020

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G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer.
Kaitlyn J Andreano, Suzanne E Wardell, Jennifer G Baker, Taylor K Desautels, Robert Baldi, Jay C Strum

Breast Cancer Res Treat· April 2020

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CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation.
Jiehui Deng, Eric S Wang, Russell W Jenkins, Shuai Li, Ruben Dries, Jay C Strum

Cancer Discov· February 2018

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CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC.
James P Stice, Suzanne E Wardell, John D Norris, Alexander P Yllanes, Holly M Alley, Jay C Strum

Mol Cancer Res· June 2017

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Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors.
John E Bisi, Jessica A Sorrentino, Jamie L Jordan, David D Darr, Patrick J Roberts, Jay C Strum

Oncotarget· June 2017

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Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion.
Shenghui He, Patrick J Roberts, Jessica A Sorrentino, John E Bisi, Hannah Storrie-White, Jay C Strum

Sci Transl Med· April 2017

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Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression.
John E Bisi, Jessica A Sorrentino, Patrick J Roberts, Francis X Tavares, Jay C Strum

Mol Cancer Ther· May 2016

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Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy.
Patrick J Roberts, John E Bisi, Jay C Strum, Austin J Combest, David B Darr

J Natl Cancer Inst· March 2012

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Rosiglitazone Induces Mitochondrial Biogenesis in Differentiated Murine 3T3-L1 and C3H/10T1/2 Adipocytes.
James X Rong, Jean-Louis D Klein, Yang Qiu, Mi Xie, Jennifer H Johnson, Jay C Strum

PPAR Res· November 2011

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MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1.
Jay C Strum, Jennifer H Johnson, James Ward, Hongbo Xie, John Feild

Mol Endocrinol· November 2009

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Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.
Ulf Risérus, Dennis Sprecher, Tony Johnson, Eric Olson, Sandra Hirschberg, Jay C Strum

Diabetes· February 2008

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Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone.
James X Rong, Yang Qiu, Michael K Hansen, Lei Zhu, Vivian Zhang, Jay C Strum

Diabetes· July 2007

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Rosiglitazone induces mitochondrial biogenesis in mouse brain.
Jay C Strum, Ron Shehee, David Virley, Jill Richardson, Michael Mattie

J Alzheimers Dis· March 2007

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PPARgamma agonists diminish serum VEGF elevation in diet-induced insulin resistant SD rats and ZDF rats.
Baichun Yang, Peiyuan Lin, Kevin M Carrick, Judi A McNulty, Lisa G Clifton, Jay C Strum

Biochem Biophys Res Commun· August 2005

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GI262570, a peroxisome proliferator-activated receptor {gamma} agonist, changes electrolytes and water reabsorption from the distal nephron in rats.
Lihong Chen, Baichun Yang, Judi A McNulty, Lisa G Clifton, Jane G Binz, Jay C Strum

J Pharmacol Exp Ther· February 2005

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Serum adiponectin as a biomarker for in vivo PPARgamma activation and PPARgamma agonist-induced efficacy on insulin sensitization/lipid lowering in rats.
Baichun Yang, Kathleen K Brown, Lihong Chen, Kevin M Carrick, Lisa G Clifton, Jay C Strum

BMC Pharmacol· October 2004

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The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.
Andrew J Brown, Susan M Goldsworthy, Ashley A Barnes, Michelle M Eilert, Lili Tcheang, Jay C Strum

J Biol Chem· March 2003

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The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
Celia P Briscoe, Mohammad Tadayyon, John L Andrews, William G Benson, Jon K Chambers, Jay C Strum

J Biol Chem· March 2003

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Tissue expression profiling using real-time PCR.
Jay C Strum, Kevin M Carrick, Joan S Stuart, Shelby A Martensen

Curr Protoc Pharmacol· November 2002

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