Publications by authors named "John D Norris"

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Discovery of BMS-986365, a first-in-class dual androgen receptor ligand-directed degrader (AR LDD) and antagonist, for the treatment of advanced prostate cancer.
Surendra Nayak, John D Norris, Massimo Ammirante, Emily Rychak, Suzanne E Wardell

Clin Cancer Res· August 2025

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Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells.
Rachid Safi, Suzanne E Wardell, Paige Watkinson, Xiaodi Qin, Marissa Lee, John D Norris

Nat Commun· September 2024

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The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide.
Susan Halabi, Siyuan Guo, Joseph J Park, David M Nanus, Daniel J George, John D Norris

Clin Cancer Res· March 2024

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A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3-]pyrimidine Core.
Vamshikrishna Reddy Sammeta, John D Norris, Sandeep Artham, Chad D Torrice, Jovita Byemerwa

ACS Med Chem Lett· July 2022

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Next-Generation Endocrine Therapies for Breast Cancer.
Donald P McDonnell, Suzanne E Wardell, Ching-Yi Chang, John D Norris

J Clin Oncol· April 2021

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The Dysregulated Pharmacology of Clinically Relevant Mutants is Normalized by Ligand-activated WT Receptor.
Kaitlyn J Andreano, Jennifer G Baker, Sunghee Park, Rachid Safi, Sandeep Artham, John D Norris

Mol Cancer Ther· July 2020

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G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer.
Kaitlyn J Andreano, Suzanne E Wardell, Jennifer G Baker, Taylor K Desautels, Robert Baldi, John D Norris

Breast Cancer Res Treat· April 2020

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Correction to: Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy.
Suzanne E Wardell, Alexander P Yllanes, Christina A Chao, Yeeun Bae, Kaitlyn J Andreano, John D Norris

Breast Cancer Res Treat· February 2020

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Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy.
Suzanne E Wardell, Alexander P Yllanes, Christina A Chao, Yeeun Bae, Kaitlyn J Andreano, John D Norris

Breast Cancer Res Treat· January 2020

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The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer.
Kimberly J Cocce, Jeff S Jasper, Taylor K Desautels, Logan Everett, Suzanne Wardell, John D Norris

Cell Rep· October 2019

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HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer.
Dorhyun Johng, Gonzalo Torga, Charles M Ewing, Kideok Jin, John D Norris

Prostate· March 2019

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Targeting mutant estrogen receptors.
Suzanne E Wardell, John D Norris, Donald P McDonnell

Elife· January 2019

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Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.
George S Tria, Tinya Abrams, Jason Baird, Heather E Burks, Brant Firestone, John D Norris

J Med Chem· April 2018

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Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.
Donald P McDonnell, John D Norris, Ching-Yi Chang

Cancer Cell· February 2018

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CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC.
James P Stice, Suzanne E Wardell, John D Norris, Alexander P Yllanes, Holly M Alley

Mol Cancer Res· June 2017

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Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer.
John D Norris, Stephanie J Ellison, Jennifer G Baker, David B Stagg, Suzanne E Wardell

J Clin Invest· June 2017

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MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
Jessica L Christenson, Kiel T Butterfield, Nicole S Spoelstra, John D Norris, Jatinder S Josan

Horm Cancer· April 2017

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Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer.
Heather E Burks, Tinya Abrams, Christina A Kirby, Jason Baird, Alexander Fekete, John D Norris

J Med Chem· April 2017

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Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer.
Julie A Pollock, Suzanne E Wardell, Alexander A Parent, David B Stagg, Stephanie J Ellison, John D Norris

Nat Chem Biol· October 2016

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Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer.
Suzanne E Wardell, Matthew J Ellis, Holly M Alley, Koleen Eisele, Todd VanArsdale, John D Norris

Clin Cancer Res· November 2015

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Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging.
Jeffrey L Gustafson, Taavi K Neklesa, Carly S Cox, Anke G Roth, Dennis L Buckley, John D Norris

Angew Chem Int Ed Engl· August 2015

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Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer.
Donald P McDonnell, Suzanne E Wardell, John D Norris

J Med Chem· June 2015

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Obesity, cholesterol metabolism, and breast cancer pathogenesis.
Donald P McDonnell, Sunghee Park, Matthew T Goulet, Jeff Jasper, Suzanne E Wardell, John D Norris

Cancer Res· September 2014

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The homeodomain protein HOXB13 regulates the cellular response to androgens.
John D Norris, Ching-Yi Chang, Bryan M Wittmann, Rebecca S Kunder, Huaxia Cui

Mol Cell· November 2009

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Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists.
James D Joseph, Bryan M Wittmann, Mary A Dwyer, Huaxia Cui, Delita A Dye, John D Norris

Proc Natl Acad Sci U S A· July 2009

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