Publications by authors named "James D Joseph"

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Selective estrogen receptor degraders with novel structural motifs induce regression in a tamoxifen-resistant breast cancer xenograft.
Steven P Govek, Celine Bonnefous, Jackaline D Julien, Johnny Y Nagasawa, Mehmet Kahraman, James D Joseph

Bioorg Med Chem Lett· February 2019

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Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young

Elife· January 2019

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Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927.
Mehmet Kahraman, Steven P Govek, Johnny Y Nagasawa, Andiliy Lai, Celine Bonnefous, James D Joseph

ACS Med Chem Lett· January 2019

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Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cancer.
Johnny Nagasawa, Steven Govek, Mehmet Kahraman, Andiliy Lai, Celine Bonnefous, James D Joseph

J Med Chem· September 2018

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The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young

Elife· July 2016

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Optimization of an indazole series of selective estrogen receptor degraders: Tumor regression in a tamoxifen-resistant breast cancer xenograft.
Steven P Govek, Johnny Y Nagasawa, Karensa L Douglas, Andiliy G Lai, Mehmet Kahraman, James D Joseph

Bioorg Med Chem Lett· November 2015

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Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.
Andiliy Lai, Mehmet Kahraman, Steven Govek, Johnny Nagasawa, Celine Bonnefous, James D Joseph

J Med Chem· June 2015

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A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509.
James D Joseph, Nhin Lu, Jing Qian, John Sensintaffar, Gang Shao

Cancer Discov· September 2013

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ARN-509: a novel antiandrogen for prostate cancer treatment.
Nicola J Clegg, John Wongvipat, James D Joseph, Chris Tran, Samedy Ouk

Cancer Res· March 2012

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An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy.
Christopher R Orr, Heather L Montie, Yuhong Liu, Elena Bolzoni, Shannon C Jenkins, James D Joseph

J Biol Chem· November 2010

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WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration.
Mary A Dwyer, James D Joseph, Hilary E Wade, Matthew L Eaton, Rebecca S Kunder

Cancer Res· November 2010

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Pharmacological targeting of the mitochondrial phosphatase PTPMT1.
Dahlia Doughty-Shenton, James D Joseph, Ji Zhang, David J Pagliarini, Youngjun Kim

J Pharmacol Exp Ther· May 2010

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The homeodomain protein HOXB13 regulates the cellular response to androgens.
John D Norris, Ching-Yi Chang, Bryan M Wittmann, Rebecca S Kunder, Huaxia Cui, James D Joseph

Mol Cell· November 2009

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Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro.
Daniel E Frigo, Andrea B Sherk, Bryan M Wittmann, John D Norris, Qianben Wang, James D Joseph

Mol Endocrinol· September 2009

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Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists.
James D Joseph, Bryan M Wittmann, Mary A Dwyer, Huaxia Cui, Delita A Dye

Proc Natl Acad Sci U S A· July 2009

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Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands.
John David Norris, James David Joseph, Andrea Barreto Sherk, Dalia Juzumiene, Philip Stewart Turnbull

Chem Biol· April 2009

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PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans.
James D Joseph, Scott N Daigle, Anthony R Means

J Biol Chem· July 2004

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Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus.
Shannon M Lemrow, Kristin A Anderson, James D Joseph, Thomas J Ribar, Pamela K Noeldner

J Biol Chem· March 2004

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The peptidyl-prolyl isomerase Pin1.
James D Joseph, Elisabeth S Yeh, Katherine I Swenson, Anthony R Means, Winkler

Prog Cell Cycle Res· December 2003

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Proteomic analysis of calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences.
Ethan E Corcoran, James D Joseph, Justin A MacDonald, Christopher D Kane, Timothy A J Haystead

J Biol Chem· March 2003

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Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe.
Mark R Flory, Mary Morphew, James D Joseph, Anthony R Means, Trisha N Davis

Cell Growth Differ· February 2002

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Calcium binding is required for calmodulin function in Aspergillus nidulans.
James D Joseph, Anthony R Means

Eukaryot Cell· February 2002

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