Publications by authors named "David Watt"

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A novel amino-pyrimidine inhibitor suppresses tumor growth via microtubule destabilization and Bmi-1 down-regulation.
Lijie Gao, Jiawei Liu, Rui Zhang, Xi Chen, Mo Wang, David Watt

Biochem Pharmacol· March 2025

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S6K1 is a Targetable Vulnerability in Tumors Exhibiting Plasticity and Therapy Resistance.
Saptadwipa Ganguly, Ravshan Burikhanov, Vitaliy M Sviripa, Sally Ellingson, Jieyun Jiang, David S Watt

Int J Biol Sci· January 2025

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Inhibition of Carbohydrate Metabolism Potentiated by the Therapeutic Effects of Oxidative Phosphorylation Inhibitors in Colon Cancer Cells.
Lichao Guo, Baochen Zhang, Wen Zhang, Yanqi Xie, Xi Chen, David S Watt

Cancers (Basel)· April 2024

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Genomic screening methodology not requiring barcoding: Single nucleotide polymorphism-based, mixed-cell screening (SMICS).
Zhuwei Zhang, Xi Chen, Wen Zhang, Jinpeng Liu, Yanqi Xie, David S Watt

Genomics· September 2023

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Crizotinib induces Par-4 secretion from normal cells and GRP78 expression on the cancer cell surface for selective tumor growth inhibition.
Ravshan Burikhanov, Saptadwipa Ganguly, Sally Ellingson, Vitaliy M Sviripa, Nathalia Araujo, David S Watt

Am J Cancer Res· March 2023

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Chalcone Derivative CX258 Suppresses Colorectal Cancer via Inhibiting the TOP2A/Wnt/β-Catenin Signaling.
Xi Chen, Xiaocheng Lv, Lijie Gao, Jiawei Liu, Wei Wang, David S Watt

Cells· March 2023

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Anti-neoplastic sulfonamides alter the metabolic homeostasis and disrupt the suppressor activity of regulatory T cells.
Roberto Gedaly, Virgilius Cornea, Lilia Turcios, Jacob S Edmisson, Dwight D Harris, David S Watt

Sci Rep· November 2022

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Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells.
Lichao Guo, Wen Zhang, Yanqi Xie, Xi Chen, Emma E Olmstead, David S Watt

Mol Cancer Ther· May 2022

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A Benzenesulfonamide-Based Mitochondrial Uncoupler Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Epithelial Ovarian Cancer.
Fangfang Bi, Ziyan Jiang, Wonmin Park, Tobias M P Hartwich, Zhiping Ge, David S Watt

Mol Cancer Ther· December 2021

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Potent Synergistic Effect on C-Myc-Driven Colorectal Cancers Using a Novel Indole-Substituted Quinoline with a Plk1 Inhibitor.
Yanqi Xie, Wen Zhang, Lichao Guo, Liliia M Kril, Kristin L Begley, David S Watt

Mol Cancer Ther· October 2021

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Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents.
Jared T Hammill, Vitaliy M Sviripa, Liliia M Kril, Diana Ortiz, Corinne M Fargo, David S Watt

J Med Chem· August 2021

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Broad-Spectrum Antifungal Agents: Fluorinated Aryl- and Heteroaryl-Substituted Hydrazones.
Nishad Thamban Chandrika, Emily K Dennis, Katelyn R Brubaker, Stefan Kwiatkowski, David S Watt

ChemMedChem· January 2021

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Epigenetic Regulation of Wnt Signaling by Carboxamide-Substituted Benzhydryl Amines that Function as Histone Demethylase Inhibitors.
Wen Zhang, Vitaliy M Sviripa, Yanqi Xie, Tianxin Yu, Meghan G Haney, David S Watt

iScience· December 2020

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Mitochondrial uncoupling and the disruption of the metabolic network in hepatocellular carcinoma.
Lilia Turcios, Francesc Marti, David S Watt, Lilia M Kril, Aman Khurana

Oncotarget· August 2020

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Pictet-Spengler condensations using 4-(2-aminoethyl)coumarins.
Vitaliy M Sviripa, Michael V Fiandalo, Kristin L Begley, Przemyslaw Wyrebek, Liliia M Kril, David S Watt

New J Chem· August 2020

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Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
Buyun Tang, Mykhaylo S Frasinyuk, Vimbai M Chikwana, Krishna K Mahalingan, Cynthia A Morgan, David S Watt

J Med Chem· April 2020

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A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise.
Kaitlind C Howard, Emily K Dennis, David S Watt, Sylvie Garneau-Tsodikova

Chem Soc Rev· April 2020

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Novel chemotherapeutic agent, FND-4b, activates AMPK and inhibits colorectal cancer cell proliferation.
Heather F Sinner, Jeremy Johnson, Piotr G Rychahou, David S Watt, Yekaterina Y Zaytseva

PLoS One· March 2020

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An Underlying Mechanism of Dual Wnt Inhibition and AMPK Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors.
Wen Zhang, Vitaliy M Sviripa, Liliia M Kril, Tianxin Yu, Yanqi Xie, David S Watt

J Med Chem· December 2019

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Autophagic flux modulation by Wnt/β-catenin pathway inhibition in hepatocellular carcinoma.
Lilia Turcios, Eduardo Chacon, Catherine Garcia, Pedro Eman, Virgilius Cornea, David S Watt

PLoS One· November 2019

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Induction of AMPK activation by N,N'-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers.
Jeremy Johnson, Piotr Rychahou, Vitaliy M Sviripa, Heidi L Weiss, Chunming Liu, David S Watt

PLoS One· November 2019

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Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish.
Yanqi Xie, Liliia M Kril, Tianxin Yu, Wen Zhang, Mykhaylo S Frasinyuk, David S Watt

Sci Rep· April 2019

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N,N'-diaryl-bishydrazones in a biphenyl platform: Broad spectrum antifungal agents.
Nishad Thamban Chandrika, Emily K Dennis, Sanjib K Shrestha, Huy X Ngo, Keith D Green, David S Watt

Eur J Med Chem· February 2019

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Efficient Synthesis of Aurone Mannich Bases and Evaluation of their Antineoplastic Activity in PC-3 Prostate Cancer Cells.
Antonina V Popova, Mykhaylo S Frasinyuk, Svitlana P Bondarenko, Wen Zhang, Yanqi Xie, David S Watt

Chem Zvesti· October 2018

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Mathematical modeling of intracrine androgen metabolism in prostate cancer: Methodological aspects.
Sarah F Cook, Michael V Fiandalo, David S Watt, Yue Wu, James L Mohler

Prostate· June 2018

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