Publications by authors named "David Wedge"

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Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma.
Tongwu Zhang, Wei Zhao, Christopher Wirth, Marcos Díaz-Gay, Jinhu Yin, David C Wedge

Nature· December 2025

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Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations.
John P McElderry, Tongwu Zhang, Wei Zhao, Phuc H Hoang, Samuel Anyaso-Samuel, David C Wedge

Nat Commun· December 2025

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Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry.
Kazzem Gheybi, Pamela X Y Soh, Jue Jiang, Tumisang M N Mbeki, Melanie Louw, David C Wedge

Nat Commun· October 2025

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Single base focal hypermutation cooccurs with structural variation as an early event in advanced prostate tumourigenesis with ancestry specific independence: a multi-ancestral observational study.
Jue Jiang, Avraam Tapinos, Ruotian Huang, M S Riana Bornman, Phillip Stricker, David Wedge

Res Sq· October 2025

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The landscape of microbial associations in human cancer.
Abraham Gihawi, Henry M Wood, Jeremy Clark, Justin O'Grady, Rosalind A Eeles, David C Wedge

Sci Transl Med· September 2025

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Panorama of Chromosomal Instability in Lung Cancer.
Yang Yang, Xiaoming Zhong, William Phillips, Wei Zhao, Phuc H Hoang, David C Wedge

medRxiv· September 2025

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The mutagenic forces shaping the genomes of lung cancer in never smokers.
Marcos Díaz-Gay, Tongwu Zhang, Phuc H Hoang, Charles Leduc, Marina K Baine, David C Wedge

Nature· August 2025

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Examining the Role of Extrachromosomal DNA in 1,216 Lung Cancers.
Azhar Khandekar, Phuc H Hoang, Jens Luebeck, Marcos Díaz-Gay, Wei Zhao, David C Wedge

bioRxiv· July 2025

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Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A.
Charlotte K Brierley, Bon Ham Yip, Giulia Orlando, Jeremy Wen, Sean Wen, David C Wedge

Nat Genet· June 2025

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Identification and Validation of a Previously Missed Mutational Signature in Colorectal Cancer.
Mariya Kazachkova, Burçak Otlu, Marcos Díaz-Gay, Ammal Abbasi, Sarah Moody, David C Wedge

bioRxiv· June 2025

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Genomic landscape of diffuse glioma revealed by whole genome sequencing.
Ben Kinnersley, Josephine Jung, Alex J Cornish, Daniel Chubb, Ross Laxton, David C Wedge

Nat Commun· May 2025

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APOBEC affects tumor evolution and age at onset of lung cancer in smokers.
Tongwu Zhang, Jian Sang, Phuc H Hoang, Wei Zhao, Jennifer Rosenbaum, David C Wedge

Nat Commun· May 2025

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Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction.
Adriana Salcedo, Maxime Tarabichi, Alex Buchanan, Shadrielle M G Espiritu, Hongjiu Zhang, David C Wedge

Nat Biotechnol· April 2025

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Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition.
Tongwu Zhang, Wei Zhao, Christopher Wirth, Marcos Díaz-Gay, Jinhu Yin, David C Wedge

bioRxiv· March 2025

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Causes of evolutionary divergence in prostate cancer.
Emre Esentürk, Atef Sahli, Valeriia Haberland, Aleksandra Ziuboniewicz, Christopher Wirth, David C Wedge

ArXiv· March 2025

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An integrative multiparametric approach stratifies putative distinct phenotypes of blast phase chronic myelomonocytic leukemia.
Kristian Gurashi, Yu-Hung Wang, Fabio M R Amaral, Katherine Spence, Rachel Cant, David C Wedge

Cell Rep Med· February 2025

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Genomes and epigenomes of matched normal and tumor breast tissue reveal diverse evolutionary trajectories and tumor-host interactions.
Bin Zhu, Avraam Tapinos, Hela Koka, Priscilla Ming Yi Lee, Tongwu Zhang, David C Wedge

Am J Hum Genet· December 2024

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Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project.
Máire Ní Leathlobhair, Anna Frangou, Ben Kinnersley, Alex J Cornish, Daniel Chubb, David C Wedge

Nat Commun· October 2024

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Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology.
Ben Kinnersley, Amit Sud, Andrew Everall, Alex J Cornish, Daniel Chubb, David Wedge

Nat Genet· September 2024

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The genomic landscape of 2,023 colorectal cancers.
Alex J Cornish, Andreas J Gruber, Ben Kinnersley, Daniel Chubb, Anna Frangou, David C Wedge

Nature· September 2024

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Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma.
Richard Culliford, Samuel E D Lawrence, Charlie Mills, Zayd Tippu, Daniel Chubb, David Wedge

Nat Commun· July 2024

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AmplificationTimeR: an R package for timing sequential amplification events.
G Maria Jakobsdottir, Stefan C Dentro, Robert G Bristow, David C Wedge

Bioinformatics· June 2024

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Kataegis associated mutational processes linked to adverse prostate cancer presentation in African men.
Vanessa Hayes, Jue Jiang, Avraam Tapinos, Ruotian Huang, Riana Bornman, David Wedge

Res Sq· June 2024

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Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival.
Michael J Haley, Leoma Bere, James Minshull, Sokratia Georgaka, Natalia Garcia-Martin, David C Wedge

Sci Adv· May 2024

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The mutagenic forces shaping the genomic landscape of lung cancer in never smokers.
Marcos Díaz-Gay, Tongwu Zhang, Phuc H Hoang, Azhar Khandekar, Wei Zhao, David C Wedge

medRxiv· May 2024

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