Publications by authors named "David Wustrow"

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Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study.
Robert Bissonnette, Janet DuBois, Paola Facheris, Ester Del Duca, Madeline Kim, David Wustrow

Allergy· April 2024

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Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy.
Jeffrey J Jackson, Grant M Shibuya, Buvana Ravishankar, Lavanya Adusumilli, Delia Bradford, David J Wustrow

J Med Chem· October 2022

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EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22.
Aparna Jorapur, Lisa A Marshall, Scott Jacobson, Mengshu Xu, Sachie Marubayashi, David Wustrow

PLoS Pathog· January 2022

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Tumors establish resistance to immunotherapy by regulating T recruitment via CCR4.
Lisa A Marshall, Sachie Marubayashi, Aparna Jorapur, Scott Jacobson, Mikhail Zibinsky, David Wustrow

J Immunother Cancer· November 2020

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Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity and .
Yamini M Ohol, Michael T Sun, Gene Cutler, Paul R Leger, Dennis X Hu, David Wustrow

Mol Cancer Ther· October 2020

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Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors.
Omar Robles, Jeffrey J Jackson, Lisa Marshall, Oezcan Talay, David Chian, David J Wustrow

J Med Chem· August 2020

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Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity.
Paul R Leger, Dennis X Hu, Berenger Biannic, Minna Bui, Xinping Han, David J Wustrow

J Med Chem· May 2020

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Discovery of a Potent and Selective CCR4 Antagonist That Inhibits T Trafficking into the Tumor Microenvironment.
Jeffrey J Jackson, John M Ketcham, Ashkaan Younai, Betty Abraham, Berenger Biannic, David J Wustrow

J Med Chem· July 2019

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The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma.
Ronan Le Moigne, Blake T Aftab, Stevan Djakovic, Eugen Dhimolea, Eduardo Valle, David Wustrow

Mol Cancer Ther· November 2017

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Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083).
Han-Jie Zhou, Jinhai Wang, Bing Yao, Steve Wong, Stevan Djakovic, David Wustrow

J Med Chem· December 2015

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Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis.
Daniel J Anderson, Ronan Le Moigne, Stevan Djakovic, Brajesh Kumar, Julie Rice, David Wustrow

Cancer Cell· November 2015

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Discovery of a novel potent GABA(B) receptor agonist.
Feng Xu, Ge Peng, Thu Phan, Usha Dilip, Jian Lu Chen, David J Wustrow

Bioorg Med Chem Lett· November 2011

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Oxadiazolone bioisosteres of pregabalin and gabapentin.
David J Wustrow, Thomas R Belliotti, Thomas Capiris, Clare O Kneen, Justin S Bryans

Bioorg Med Chem Lett· January 2009

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Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation.
Daniel C Broom, David J Matson, Elizabeth Bradshaw, Marianne E Buck, Robin Meade, David J Wustrow

J Pharmacol Exp Ther· December 2008

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1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.
Qin Guo, Jayaraman Chandrasekhar, David Ihle, David J Wustrow, Bertrand L Chenard

Bioorg Med Chem Lett· September 2008

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Aminopyrazine CB1 receptor inverse agonists.
David J Wustrow, George D Maynard, Jun Yuan, He Zhao, Jianmin Mao

Bioorg Med Chem Lett· June 2008

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Carboxylate bioisosteres of pregabalin.
Jacob B Schwarz, Norman L Colbry, Zhijian Zhu, Brian Nichelson, Nancy S Barta, David J Wustrow

Bioorg Med Chem Lett· July 2006

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Carboxylate bioisosteres of gabapentin.
Carmen E Burgos-Lepley, Lisa R Thompson, Clare O Kneen, Simon A Osborne, Justin S Bryans, David J Wustrow

Bioorg Med Chem Lett· May 2006

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Heteroaromatic side-chain analogs of pregabalin.
Robert M Schelkun, Po-wai Yuen, David J Wustrow, Jack Kinsora, Ti-Zhi Su

Bioorg Med Chem Lett· May 2006

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The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.
Lain-Yen Hu, Peter A Boxer, Suzanne R Kesten, Huangshu J Lei, David J Wustrow

Bioorg Med Chem Lett· May 2006

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Structure-activity relationships of pregabalin and analogues that target the alpha(2)-delta protein.
Thomas R Belliotti, Thomas Capiris, I Victor Ekhato, Jack J Kinsora, Mark J Field, David J Wustrow

J Med Chem· April 2005

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Novel cyclopropyl beta-amino acid analogues of pregabalin and gabapentin that target the alpha2-delta protein.
Jacob B Schwarz, Sian E Gibbons, Shelley R Graham, Norman L Colbry, Peter R Guzzo, David J Wustrow

J Med Chem· April 2005

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Orally active oxime derivatives of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one. Synthesis and pharmacological activity.
Bastiaan J Venhuis, Durk Dijkstra, David Wustrow, Len T Meltzer, Lawrence D Wise

J Med Chem· September 2003

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Orally active analogues of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one: synthesis and pharmacological activity.
Bastiaan J Venhuis, Durk Dijkstra, David J Wustrow, Leonard T Meltzer, Lawrence D Wise

J Med Chem· February 2003

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A new type of prodrug of catecholamines: an opportunity to improve the treatment of Parkinson's disease.
Bastiaan J Venhuis, Nienke Rodenhuis, Håkan V Wikström, David Wustrow, Leonard T Meltzer

J Med Chem· June 2002

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