Publications by authors named "Davide Trotti"

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Neuronal activity-dependent gene dysregulation in iNeuronal models of ALS/FTD pathogenesis.
Layla T Ghaffari, Emily A Welebob, Sarah E B Newton, Ashley V Boehringer, Kelly L Cyliax, Davide Trotti

Am J Physiol Cell Physiol· October 2025

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Increased neuronal activity restores circadian function in models of C9orf72-ALS/FTD.
Sho Inami, Benjamin P Jenny, Oghenerukevwe Akpoghiran, Sara I Gallagher, Alexandra K Strich, Davide Trotti

bioRxiv· August 2025

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NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats.
Kevin M Kim, Amandeep Girdhar, Maria E Cicardi, Vaishnavi Kankate, Miyuki Hayashi, Davide Trotti

Commun Biol· January 2025

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Neuronal Activity-Dependent Gene Dysregulation in iNeuronal Models of ALS/FTD Pathogenesis.
Layla T Ghaffari, Emily Welebob, Ashley Boehringer, Kelly Cyliax, Piera Pasinelli, Davide Trotti

bioRxiv· January 2025

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C9orf72 role in myeloid cells: new perspectives in the investigation of the neuro-immune crosstalk in amyotrophic lateral sclerosis and frontotemporal dementia.
Maria Elena Cicardi, Davide Trotti

Ann Transl Med· December 2024

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ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial-to-mesenchymal transition in cranial neural crest specification.
Samantha M Barnada, Aida Giner de Gracia, Cruz Morenilla-Palao, Maria Teresa López-Cascales, Chiara Scopa, Davide Trotti

Am J Hum Genet· October 2024

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Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes.
Andrew T Nelson, Maria Elena Cicardi, Shashirekha S Markandaiah, John Ys Han, Nancy J Philp, Davide Trotti

EMBO Rep· May 2024

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EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS.
Mark W Urban, Brittany A Charsar, Nicolette M Heinsinger, Shashirekha S Markandaiah, Lindsay Sprimont, Davide Trotti

Elife· January 2024

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JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer's disease.
Chiara Scopa, Samantha M Barnada, Maria E Cicardi, Mo Singer, Davide Trotti

Nat Commun· December 2023

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EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS.
Mark W Urban, Brittany A Charsar, Nicolette M Heinsinger, Shashirekha S Markandaiah, Lindsay Sprimont, Davide Trotti

bioRxiv· October 2023

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Loss of PML nuclear bodies in familial amyotrophic lateral sclerosis-frontotemporal dementia.
Francesco Antoniani, Marco Cimino, Laura Mediani, Jonathan Vinet, Enza M Verde, Davide Trotti

Cell Death Discov· July 2023

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Differential response of C9orf72 transcripts following neuronal depolarization.
Layla T Ghaffari, Davide Trotti, Aaron R Haeusler

iScience· June 2023

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Breakdown of the central synapses in C9orf72-linked ALS/FTD.
Layla T Ghaffari, Davide Trotti, Aaron R Haeusler, Brigid K Jensen

Front Mol Neurosci· September 2022

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Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice.
Brigid K Jensen, Kevin J McAvoy, Nicolette M Heinsinger, Angelo C Lepore, Hristelina Ilieva, Davide Trotti

Glia· July 2022

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Altered Bioenergetics and Metabolic Homeostasis in Amyotrophic Lateral Sclerosis.
Andrew T Nelson, Davide Trotti

Neurotherapeutics· July 2022

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NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.
Amanda M Gleixner, Brandie Morris Verdone, Charlton G Otte, Eric N Anderson, Nandini Ramesh, Davide Trotti

Nat Commun· June 2022

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A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes.
Brandie Morris Verdone, Maria Elena Cicardi, Xinmei Wen, Sindhu Sriramoji, Katelyn Russell, Davide Trotti

Sci Rep· April 2022

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Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis.
Karthik Krishnamurthy, Davide Trotti, Piera Pasinelli, Brigid Jensen

J Vis Exp· July 2021

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Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis.
Maria Elena Cicardi, Lara Marrone, Mimoun Azzouz, Davide Trotti

EMBO J· May 2021

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Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment.
Brigid K Jensen, Martin H Schuldi, Kevin McAvoy, Katelyn A Russell, Ashley Boehringer, Davide Trotti

EMBO Mol Med· May 2020

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Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis.
Loqman A Mohamed, Shashirekha S Markandaiah, Silvia Bonanno, Piera Pasinelli, Davide Trotti

Exp Neurol· June 2019

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Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress.
Thomas Westergard, Kevin McAvoy, Katelyn Russell, Xinmei Wen, Yu Pang, Davide Trotti

EMBO Mol Med· February 2019

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miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS.
Roy Maimon, Ariel Ionescu, Avichai Bonnie, Sahar Sweetat, Shane Wald-Altman, Davide Trotti

J Neurosci· June 2018

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Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha.
Azadeh Kia, Kevin McAvoy, Karthik Krishnamurthy, Davide Trotti, Piera Pasinelli

Glia· May 2018

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Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.
Yingxiao Shi, Shaoyu Lin, Kim A Staats, Yichen Li, Wen-Hsuan Chang, Davide Trotti

Nat Med· March 2018

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