Publications by authors named "Piera Pasinelli"

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How Patients With Amyotrophic Lateral Sclerosis Perceive Respiratory Interventions: A Mixed-Methods Study to Inform Implementation Efforts.
Jason Ackrivo, Danny Bracy, Lauren B Elman, John Hansen-Flaschen, Zachary Simmons, Piera Pasinelli

Neurol Clin Pract· December 2025

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Neuronal activity-dependent gene dysregulation in iNeuronal models of ALS/FTD pathogenesis.
Layla T Ghaffari, Emily A Welebob, Sarah E B Newton, Ashley V Boehringer, Kelly L Cyliax, Piera Pasinelli

Am J Physiol Cell Physiol· October 2025

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Re-Analyses of Samples From Amyotrophic Lateral Sclerosis Patients and Controls Identify Many Novel Small RNAs With Diagnostic And Prognostic Potential.
Phillipe Loher, Eric Londin, Hristelina Ilieva, Piera Pasinelli, Isidore Rigoutsos

Mol Neurobiol· July 2025

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Neuronal Activity-Dependent Gene Dysregulation in iNeuronal Models of ALS/FTD Pathogenesis.
Layla T Ghaffari, Emily Welebob, Ashley Boehringer, Kelly Cyliax, Piera Pasinelli

bioRxiv· January 2025

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Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes.
Andrew T Nelson, Maria Elena Cicardi, Shashirekha S Markandaiah, John Ys Han, Nancy J Philp, Piera Pasinelli

EMBO Rep· May 2024

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EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS.
Mark W Urban, Brittany A Charsar, Nicolette M Heinsinger, Shashirekha S Markandaiah, Lindsay Sprimont, Piera Pasinelli

Elife· January 2024

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Editorial: The role of glial cells in neurodegeneration.
Piera Pasinelli, Kathrin Meyer, Laura Ferraiuolo, Robert A Culibrk, Rita Sattler

Front Mol Med· January 2024

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EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS.
Mark W Urban, Brittany A Charsar, Nicolette M Heinsinger, Shashirekha S Markandaiah, Lindsay Sprimont, Piera Pasinelli

bioRxiv· October 2023

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Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice.
Brigid K Jensen, Kevin J McAvoy, Nicolette M Heinsinger, Angelo C Lepore, Hristelina Ilieva, Piera Pasinelli

Glia· July 2022

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A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes.
Brandie Morris Verdone, Maria Elena Cicardi, Xinmei Wen, Sindhu Sriramoji, Katelyn Russell, Piera Pasinelli

Sci Rep· April 2022

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Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis.
Karthik Krishnamurthy, Davide Trotti, Piera Pasinelli, Brigid Jensen

J Vis Exp· July 2021

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Synaptic dysfunction in amyotrophic lateral sclerosis/frontotemporal dementia: Therapeutic strategies and novel biomarkers.
Karthik Krishnamurthy, Piera Pasinelli

J Neurosci Res· June 2021

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Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment.
Brigid K Jensen, Martin H Schuldi, Kevin McAvoy, Katelyn A Russell, Ashley Boehringer, Piera Pasinelli

EMBO Mol Med· May 2020

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AAV2-BDNF promotes respiratory axon plasticity and recovery of diaphragm function following spinal cord injury.
Brittany A Charsar, Michael A Brinton, Katherine Locke, Anna Y Chen, Biswarup Ghosh, Piera Pasinelli

FASEB J· December 2019

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Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.
Ian Casci, Karthik Krishnamurthy, Sukhleen Kour, Vadreenath Tripathy, Nandini Ramesh, Piera Pasinelli

Nat Commun· December 2019

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Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis.
Loqman A Mohamed, Shashirekha S Markandaiah, Silvia Bonanno, Piera Pasinelli, Davide Trotti

Exp Neurol· June 2019

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Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress.
Thomas Westergard, Kevin McAvoy, Katelyn Russell, Xinmei Wen, Yu Pang, Piera Pasinelli

EMBO Mol Med· February 2019

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Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha.
Azadeh Kia, Kevin McAvoy, Karthik Krishnamurthy, Davide Trotti, Piera Pasinelli

Glia· May 2018

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Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies.
Loqman A Mohamed, Shashirekha Markandaiah, Silvia Bonanno, Piera Pasinelli, Davide Trotti

AAPS J· November 2017

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Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS.
Lauren Taylor Rosenblum, Shashirekha Shamamandri-Markandaiah, Biswarup Ghosh, Emily Foran, Angelo C Lepore, Piera Pasinelli

Exp Neurol· June 2017

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Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene.
Xinmei Wen, Thomas Westergard, Piera Pasinelli, Davide Trotti

Neurosci Lett· January 2017

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Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD.
Thomas Westergard, Brigid K Jensen, Xinmei Wen, Jingli Cai, Elizabeth Kropf, Piera Pasinelli

Cell Rep· October 2016

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Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis.
Hisham Qosa, Jessica Lichter, Mark Sarlo, Shashirekha S Markandaiah, Kevin McAvoy, Piera Pasinelli

Glia· August 2016

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Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.
J Gavin Daigle, Karthik Krishnamurthy, Nandini Ramesh, Ian Casci, John Monaghan, Piera Pasinelli

Acta Neuropathol· April 2016

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Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders.
Hisham Qosa, David S Miller, Piera Pasinelli, Davide Trotti

Brain Res· December 2015

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