Publications by authors named "Daxin Chen"

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Nelumbinis Plumula attenuates high-fat-induced inflammation in non-alcoholic fatty liver through the NOX/NF-κB pathway.
Xiaoxue Zhao, Shan Lin, Jing Wang, Shiying Wu, Chenxi Ren, Daxin Chen

J Ethnopharmacol· January 2026

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Protective mechanisms of Qingda granule in hypertensive kidney injury: Focus on ERK/RSK1-mediated mitochondrial protection.
Shan Lin, Meiling Wang, Enqi Su, Lin Yao, Qihang Ding, Daxin Chen

Chin J Nat Med· December 2025

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Integrative network pharmacology and experimental study of Qingda granule in hypertension-induced endothelial dysfunction.
Yanyan Yang, Qiurong Xie, Jingyi Zeng, Meizhu Wu, Daxin Chen, Chenyu Lai

Exp Anim· October 2025

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Development and validation of a prognostic and drug sensitivity model for gastric cancer utilizing telomere-related genes.
Xiaoxiao Li, Xiaoxuan Wang, Fuxiang Yu, Zhongguo Li, Daxin Chen, Dongsheng Chen

Transl Oncol· February 2025

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Dehydrocorydaline attenuates myocardial ischemia-reperfusion injury via the FoXO signalling pathway: A multimodal study based on network pharmacology, molecular docking, and experimental study.
Hongzheng Li, Wenwen Yang, Zucheng Shang, Yingdong Lu, Aling Shen, Daxin Chen, Keji Chen

J Ethnopharmacol· January 2025

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Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Validation.
Yaoyao Xu, Qiaoyan Cai, Chunyu Zhao, Weixiang Zhang, Xinting Xu, Daxin Chen

Pharmaceuticals (Basel)· December 2024

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miR-326 overexpression inhibits colorectal cancer cell growth and proteasome activity by targeting PNO1: unveiling a novel therapeutic intervention strategy.
Yi Fang, Yulun Wu, Xinran Zhang, Lihui Wei, Liya Liu, Youqin Chen, Daxin Chen, Mian Chen, Ying Cheng

Sci Rep· October 2024

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Neointimal hyperplasia after endoluminal injury in mice is dependent on tissue factor- and angiopoietin-2 dependent interferon gamma production by fibrocytes and macrophages.
Daxin Chen, Ke Li, Lin-Lin Wei, Ning Ma, John H McVey

Front Immunol· June 2024

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Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR4/NF-κB/NLRP3 signaling in microglia.
Qiaoyan Cai, Chunyu Zhao, Yaoyao Xu, Haowei Lin, Beibei Jia, Daxin Chen

J Ethnopharmacol· April 2024

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Liensinine improves AngII-induced vascular remodeling via MAPK/TGF-β1/Smad2/3 signaling.
Peizhi Jia, Daxin Chen, Ying Zhu, Meiling Wang, Jianwei Zeng

J Ethnopharmacol· December 2023

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Therapeutic Effects of Different Animal Bile Powders on Lipid Metabolism Disorders and Their Composition Analysis.
Da-Xin Chen, Jian-Feng Chu, Shan Lin, Ling Zhang, Hong-Wei Chen

Chin J Integr Med· October 2022

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Qingda granule alleviate angiotensin ⅱ-induced hypertensive renal injury by suppressing oxidative stress and inflammation through NOX1 and NF-κB pathways.
Daxin Chen, Linzi Long, Shan Lin, Peizhi Jia, Zhengchuan Zhu, Keji Chen

Biomed Pharmacother· September 2022

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Manipulation of tissue factor-mediated basal PAR-2 signalling on macrophages determines sensitivity for IFNγ responsiveness and significantly modifies the phenotype of murine DTH.
Hannah Wilkinson, Hugh Leonard, Michael G Robson, Richard Smith, ElLi Tam, Daxin Chen

Front Immunol· September 2022

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LINC01006 and miR-3199 Serve as Novel Markers of Poor Prognosis in Colon Cancer and Regulate Cell Proliferation, Migration and Invasion.
Yaoqiang Wu, Bo Yu, Yaping Li, Fuxiang Yu, Zhongguo Li, Daxin Chen

Int J Gen Med· February 2022

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Cardiac biomarkers, cardiac injury, and comorbidities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.
Zhengchuan Zhu, Miaoran Wang, Wei Lin, Qiaoyan Cai, Ling Zhang, Daxin Chen, Keji Chen

Immun Inflamm Dis· December 2021

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Huoxin Pill inhibits isoproterenol-induced transdifferentiation and collagen synthesis in cardiac fibroblasts through the TGF-β/Smads pathway.
Meizhong Peng, Meiling Yang, Yan Lu, Shan Lin, Huajian Gao, Daxin Chen

J Ethnopharmacol· July 2021

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Comprehensive chemical study on different organs of cultivated and wild Sarcandra glabra using ultra-high performance liquid chromatography time-of-flight mass spectrometry (UHPLC-TOF-MS).
Cai-Yun Wang, Jing-Guang Lu, Da-Xin Chen, Jing-Rong Wang, Kai-Si Che

Chin J Nat Med· May 2021

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Comparison of long-term outcomes of laparoscopic and open sphincter-preserving total mesorectal excision for low rectal cancer.
Yaoqiang Wu, Zhongguo Li, Fuxiang Yu, Daxin Chen, Feng Jiang

J BUON· February 2021

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PAR-1 signaling on macrophages is required for effective in vivo delayed-type hypersensitivity responses.
Hannah Wilkinson, Hugh Leonard, Daxin Chen, Toby Lawrence, Michael Robson

iScience· January 2021

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Qingda granules attenuate hypertensive cardiac remodeling and inflammation in spontaneously hypertensive rats.
Xiangyan Wu, Aling Shen, Liya Bao, Meizhu Wu, Xiaoying Lin, Youqin Chen, Daxin Chen

Biomed Pharmacother· September 2020

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Protective Role of C3aR (C3a Anaphylatoxin Receptor) Against Atherosclerosis in Atherosclerosis-Prone Mice.
Lin-Lin Wei, Ning Ma, Kun-Yi Wu, Jia-Xing Wang, Teng-Yue Diao, Daxin Chen

Arterioscler Thromb Vasc Biol· September 2020

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Regression of Atherosclerosis in ApoE-/- Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel "Cytotopic" Anti-Thrombin Without Prolonged Anticoagulation.
Daxin Chen, Ke Li, Sam Festenstein, Julieta Karegli, Hannah Wilkinson

J Am Heart Assoc· July 2020

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LRP6 Ectodomain Prevents SDF-1/CXCR4-Induced Breast Cancer Metastasis to Lung.
Jiankang Zhang, Jinxiao Chen, Da Wo, Hongwei Yan, Peng Liu, Daxin Chen

Clin Cancer Res· August 2019

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Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury.
Jian Lou, Yue Hu, Min-Dan Wu, Luan-Qing Che, Yin-Fang Wu, Chen Zhu, Zhi-Hua Chen, Da-Xin Chen

Acta Pharmacol Sin· June 2019

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Inhibition of Angiopoietin-2 Production by Myofibrocytes Inhibits Neointimal Hyperplasia After Endoluminal Injury in Mice.
Daxin Chen, Ke Li, El-Li Tham, Lin-Lin Wei, Ning Ma

Front Immunol· July 2018

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