Publications by authors named "Dean Burkin"

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Spatial proteomics reveals recombinant human laminin-111 restores adhesion signaling to laminin-α2-deficient muscle.
Hailey J Hermann, Ryan D Wuebbles, Marisela Dagda, Axel Muñoz, Lauren L Parker, Dean J Burkin

JCI Insight· November 2025

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Vemurafenib improves muscle histopathology in a mouse model of LAMA2-related congenital muscular dystrophy.
Ariany Oliveira-Santos, Marisela Dagda, Jennifer Wittmann, Robert Smalley, Dean J Burkin

Dis Model Mech· June 2023

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A gene therapy approach for the treatment of limb-girdle muscular dystrophy 2C/R5.
Hailey Hermann, Ryan D Wuebbles, Dean J Burkin

Mol Ther Methods Clin Dev· June 2023

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The alpha7 integrin subunit in astrocytes promotes endothelial blood-brain barrier integrity.
Zhihua Chen, Jack R Kelly, John E Morales, Raymond C Sun, Arpan De, Dean J Burkin

Development· March 2023

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Integrin α7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice.
Enrico Bugiardini, Andreia M Nunes, Ariany Oliveira-Santos, Marisela Dagda, Tatiana M Fontelonga, Dean J Burkin

J Am Heart Assoc· December 2022

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Transgenic overexpression of α7 integrin in smooth muscle attenuates allergen-induced airway inflammation in a murine model of asthma.
Mariam A Ba, Annemarie Aiyuk, Karla Hernández, Jon M Evasovic, Ryan D Wuebbles, Dean J Burkin

FASEB Bioadv· November 2022

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Sunitinib inhibits STAT3 phosphorylation in cardiac muscle and prevents cardiomyopathy in the mdx mouse model of Duchenne muscular dystrophy.
Ariany Oliveira-Santos, Marisela Dagda, Dean J Burkin

Hum Mol Genet· July 2022

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Tetrahydrobiopterin shifts the balance from oxidative stress to NO signalling in Duchenne muscular dystrophy.
Ryan D Wuebbles, Ariany Oliveira-Santos, Dean J Burkin

Acta Physiol (Oxf)· July 2021

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Laminin-111 Improves the Anabolic Response to Mechanical Load in Aged Skeletal Muscle.
Koyal Garg, Ziad S Mahmassani, Svyatoslav Dvoretskiy, M Carmen Valero, Heather D Huntsman, Dean J Burkin

J Gerontol A Biol Sci Med Sci· March 2021

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NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging.
Cynthia Tannous, Robin Deloux, Ahmed Karoui, Nathalie Mougenot, Dean Burkin

Int J Mol Sci· March 2021

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A retooled drug that restores ionic balance and cardiac function in dystrophin deficient hearts.
Ryan D Wuebbles, Dean J Burkin

Int J Cardiol· November 2020

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Laminin-111 protein therapy after disease onset slows muscle disease in a mouse model of laminin-α2 related congenital muscular dystrophy.
Pamela Barraza-Flores, Katherine E Bukovec, Marisela Dagda, Brandon W Conner, Ariany Oliveira-Santos, Dean J Burkin

Hum Mol Genet· August 2020

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Human laminin-111 and laminin-211 protein therapy prevents muscle disease progression in an immunodeficient mouse model of LAMA2-CMD.
Pamela Barraza-Flores, Hailey J Hermann, Christina R Bates, Tyler G Allen, Timothy T Grunert, Dean J Burkin

Skelet Muscle· June 2020

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Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity.
Takako I Jones, Guo-Liang Chew, Pamela Barraza-Flores, Spencer Schreier, Monique Ramirez, Dean J Burkin

Skelet Muscle· April 2020

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Laminin and Integrin in LAMA2-Related Congenital Muscular Dystrophy: From Disease to Therapeutics.
Pamela Barraza-Flores, Christina R Bates, Ariany Oliveira-Santos, Dean J Burkin

Front Mol Neurosci· February 2020

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Laminin-111 protein therapy enhances muscle regeneration and repair in the GRMD dog model of Duchenne muscular dystrophy.
Pamela Barraza-Flores, Tatiana M Fontelonga, Ryan D Wuebbles, Hailey J Hermann, Andreia M Nunes, Dean J Burkin

Hum Mol Genet· August 2019

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Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy.
Raffaella Willmann, Heather Gordish-Dressman, Sarina Meinen, Markus A Rüegg, Qing Yu, Dean J Burkin

J Neuromuscul Dis· July 2019

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Sunitinib promotes myogenic regeneration and mitigates disease progression in the mdx mouse model of Duchenne muscular dystrophy.
Tatiana M Fontelonga, Brennan Jordan, Andreia M Nunes, Pamela Barraza-Flores, Nicholas Bolden, Dean J Burkin

Hum Mol Genet· July 2019

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Human Galectin-1 Improves Sarcolemma Stability and Muscle Vascularization in the mdx Mouse Model of Duchenne Muscular Dystrophy.
Ryan D Wuebbles, Vivian Cruz, Pam Van Ry, Pamela Barraza-Flores, Paul D Brewer, Dean J Burkin

Mol Ther Methods Clin Dev· June 2019

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Integrin α7: a major driver and therapeutic target for glioblastoma malignancy.
Andreia M Nunes, Pamela Barraza-Flores, Christina R Smith, Dean J Burkin

Stem Cell Investig· December 2017

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Evaluation of the behavioral characteristics of the mdx mouse model of duchenne muscular dystrophy through operant conditioning procedures.
Matthew Lewon, Christina M Peters, Pam M Van Ry, Dean J Burkin, Kenneth W Hunter

Behav Processes· September 2017

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ECM-Related Myopathies and Muscular Dystrophies: Pros and Cons of Protein Therapies.
Pam M Van Ry, Tatiana M Fontelonga, Pamela Barraza-Flores, Apurva Sarathy, Andreia M Nunes, Dean J Burkin

Compr Physiol· September 2017

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Impaired fetal muscle development and JAK-STAT activation mark disease onset and progression in a mouse model for merosin-deficient congenital muscular dystrophy.
Andreia M Nunes, Ryan D Wuebbles, Apurva Sarathy, Tatiana M Fontelonga, Marianne Deries, Dean J Burkin

Hum Mol Genet· June 2017

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SU9516 Increases α7β1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy.
Apurva Sarathy, Ryan D Wuebbles, Tatiana M Fontelonga, Ashley R Tarchione, Lesley A Mathews Griner, Dean J Burkin

Mol Ther· June 2017

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PTRH2 gene mutation causes progressive congenital skeletal muscle pathology.
Jinger Doe, Angela M Kaindl, Mayumi Jijiwa, Michelle de la Vega, Hao Hu, Dean J Burkin

Hum Mol Genet· April 2017

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