Publications by authors named "Dean Clift"

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State-selective small molecule degraders that preferentially remove aggregates and oligomers.
Jakub Luptak, Dean Clift, Aamir Mukadam, Jonathan Benn, Tyler Rhinesmith, Matylda Sczaniecka-Clift

Nat Commun· November 2025

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Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21.
Shanna S Leventhal, Thomas Bisom, Dean Clift, Deepashri Rao, Kimberly Meade-White

Nat Commun· October 2024

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A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation.
Alice Fletcher, Dean Clift, Emma de Vries, Sergio Martinez Cuesta, Timothy Malcolm

Nat Commun· November 2023

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Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates.
Leo Kiss, Tyler Rhinesmith, Jakub Luptak, Claire F Dickson, Jonas Weidenhausen, Dean Clift

Nat Commun· April 2023

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TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing.
Jakub Luptak, Donna L Mallery, Aminu S Jahun, Anna Albecka, Dean Clift

Viruses· July 2022

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A functional assay for serum detection of antibodies against SARS-CoV-2 nucleoprotein.
Anna Albecka, Dean Clift, Marina Vaysburd, Tyler Rhinesmith, Sarah L Caddy

EMBO J· September 2021

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SUMOylation stabilizes sister kinetochore biorientation to allow timely anaphase.
Xue Bessie Su, Menglu Wang, Claudia Schaffner, Olga O Nerusheva, Dean Clift

J Cell Biol· July 2021

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Target-induced clustering activates Trim-Away of pathogens and proteins.
Jingwei Zeng, Ana Filipa Santos, Aamir S Mukadam, Mariana Osswald, David A Jacques, Dean Clift

Nat Struct Mol Biol· March 2021

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RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.
Leo Kiss, Dean Clift, Nadine Renner, David Neuhaus, Leo C James

Nat Commun· February 2021

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Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection.
Larisa I Labzin, Maria Bottermann, Pablo Rodriguez-Silvestre, Stian Foss, Jan Terje Andersen, Dean Clift

EMBO J· October 2019

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Publisher Correction: Acute and rapid degradation of endogenous proteins by Trim-Away.
Dean Clift, Chun So, William A McEwan, Leo C James, Melina Schuh

Nat Protoc· August 2019

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A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes.
Chun So, K Bianka Seres, Anna M Steyer, Eike Mönnich, Dean Clift

Science· June 2019

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Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.
Tomas Castro-Dopico, Thomas W Dennison, John R Ferdinand, Rebeccah J Mathews, Aaron Fleming, Dean Clift

Immunity· April 2019

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Complement C4 Prevents Viral Infection through Capsid Inactivation.
Maria Bottermann, Stian Foss, Sarah L Caddy, Dean Clift, Laurens M van Tienen

Cell Host Microbe· April 2019

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Acute and rapid degradation of endogenous proteins by Trim-Away.
Dean Clift, Chun So, William A McEwan, Leo C James, Melina Schuh

Nat Protoc· October 2018

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Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.
Gabriel Balmus, Delphine Larrieu, Ana C Barros, Casey Collins, Monica Abrudan, Dean Clift

Nat Commun· April 2018

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A Method for the Acute and Rapid Degradation of Endogenous Proteins.
Dean Clift, William A McEwan, Larisa I Labzin, Vera Konieczny, Binyam Mogessie

Cell· December 2017

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Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.
William A McEwan, Benjamin Falcon, Marina Vaysburd, Dean Clift, Adrian L Oblak

Proc Natl Acad Sci U S A· January 2017

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Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere.
Kitty F Verzijlbergen, Olga O Nerusheva, David Kelly, Alastair Kerr, Dean Clift

Elife· February 2016

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A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes.
Dean Clift, Melina Schuh

Nat Commun· July 2015

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Restarting life: fertilization and the transition from meiosis to mitosis.
Dean Clift, Melina Schuh

Nat Rev Mol Cell Biol· September 2013

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Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.
Dean Clift, Farid Bizzari, Adele L Marston

Genes Dev· March 2009

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