Publications by authors named "Dean M Messing"

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Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis.
Peter G Ruminski, Mark Massa, Joseph Strohbach, Cathleen E Hanau, Michelle Schmidt, Dean M Messing

J Med Chem· January 2016

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Mechanistic investigations of test article-induced pancreatic toxicity at the endocrine-exocrine interface in the rat.
Karrie A Brenneman, Shashi K Ramaiah, Cynthia M Rohde, Dean M Messing, Shawn P O'Neil

Toxicol Pathol· January 2014

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Substituted N-aryl-6-pyrimidinones: a new class of potent, selective, and orally active p38 MAP kinase inhibitors.
Balekudru Devadas, Shaun R Selness, Li Xing, Heather M Madsen, Laura D Marrufo, Dean M Messing

Bioorg Med Chem Lett· July 2011

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Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog.
Dale L Morris, Shawn P O'Neil, Rajesh V Devraj, Joseph P Portanova, Richard W Gilles, Dean M Messing

Toxicol Pathol· June 2010

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Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase.
John K Walker, Shaun R Selness, Rajesh V Devraj, Michael E Hepperle, Win Naing, Dean M Messing

Bioorg Med Chem Lett· April 2010

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Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation.
Heidi R Hope, Gary D Anderson, Barry L Burnette, Robert P Compton, Rajesh V Devraj, Dean M Messing

J Pharmacol Exp Ther· December 2009

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Predicting drug-drug interactions in drug discovery: where are we now and where are we going?
Matthew Hutzler, Dean M Messing, Larry C Wienkers

Curr Opin Drug Discov Devel· January 2005

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