Publications by authors named "Rajesh V Devraj"

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Discovery and characterization of atropisomer PH-797804, a p38 MAP kinase inhibitor, as a clinical drug candidate.
Li Xing, Balekudru Devadas, Rajesh V Devraj, Shaun R Selness, Huey Shieh

ChemMedChem· February 2012

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Substituted N-aryl-6-pyrimidinones: a new class of potent, selective, and orally active p38 MAP kinase inhibitors.
Balekudru Devadas, Shaun R Selness, Li Xing, Heather M Madsen, Laura D Marrufo, Rajesh V Devraj

Bioorg Med Chem Lett· July 2011

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Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase.
Shaun R Selness, Terri L Boehm, John K Walker, Balekudru Devadas, Richard C Durley, Rajesh V Devraj

Bioorg Med Chem Lett· July 2011

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Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase.
Shaun R Selness, Rajesh V Devraj, Balekudru Devadas, John K Walker, Terri L Boehm

Bioorg Med Chem Lett· July 2011

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Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog.
Dale L Morris, Shawn P O'Neil, Rajesh V Devraj, Joseph P Portanova, Richard W Gilles

Toxicol Pathol· June 2010

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Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase.
Kevin D Jerome, Michael E Hepperle, John K Walker, Li Xing, Rajesh V Devraj

Bioorg Med Chem Lett· May 2010

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Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase.
John K Walker, Shaun R Selness, Rajesh V Devraj, Michael E Hepperle, Win Naing

Bioorg Med Chem Lett· April 2010

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Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation.
Heidi R Hope, Gary D Anderson, Barry L Burnette, Robert P Compton, Rajesh V Devraj

J Pharmacol Exp Ther· December 2009

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Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase.
Shaun R Selness, Rajesh V Devraj, Joseph B Monahan, Terri L Boehm, John K Walker

Bioorg Med Chem Lett· October 2009

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Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.
Li Xing, Huey S Shieh, Shaun R Selness, Rajesh V Devraj, John K Walker

Biochemistry· July 2009

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Physiochemical drug properties associated with in vivo toxicological outcomes.
Jason D Hughes, Julian Blagg, David A Price, Simon Bailey, Gary A Decrescenzo, Rajesh V Devraj

Bioorg Med Chem Lett· September 2008

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