Publications by authors named "Jason D Hughes"

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Fragmentomic-based algorithm to computationally predict tumor-somatic, germline, and clonal hematopoiesis variant origin in liquid biopsy.
Derek W Brown, Daokun Sun, Alexander D Fine, Shai He, Michael McDevitt, Jason D Hughes

J Liq Biopsy· September 2025

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Measurement of ctDNA Tumor Fraction Identifies Informative Negative Liquid Biopsy Results and Informs Value of Tissue Confirmation.
Christian D Rolfo, Russell W Madison, Lincoln W Pasquina, Derek W Brown, Yanmei Huang, Jason D Hughes

Clin Cancer Res· June 2024

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PFRED: A computational platform for siRNA and antisense oligonucleotides design.
Simone Sciabola, Hualin Xi, Dario Cruz, Qing Cao, Christine Lawrence, Jason D Hughes

PLoS One· April 2021

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Magnesium Restores Activity to Peripheral Blood Cells in a Patient With Functionally Impaired Interleukin-2-Inducible T Cell Kinase.
Matthew K Howe, Kennichi Dowdell, Amitava Roy, Julie E Niemela, Wyndham Wilson, Jason D Hughes

Front Immunol· October 2020

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Analytical Validation of a Hybrid Capture-Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA.
Travis A Clark, Jon H Chung, Mark Kennedy, Jason D Hughes, Niru Chennagiri

J Mol Diagn· September 2018

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Estimation of kinship coefficient in structured and admixed populations using sparse sequencing data.
Jinzhuang Dou, Baoluo Sun, Xueling Sim, Jason D Hughes, Dermot F Reilly

PLoS Genet· September 2017

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BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.
Behdad Afzali, Juha Grönholm, Jana Vandrovcova, Charlotte O'Brien, Hong-Wei Sun, Jason D Hughes

Nat Immunol· July 2017

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Recurrent rhinovirus infections in a child with inherited MDA5 deficiency.
Ian T Lamborn, Huie Jing, Yu Zhang, Scott B Drutman, Jordan K Abbott, Jason D Hughes

J Exp Med· July 2017

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Mutation Detection in an Antibody-Producing Chinese Hamster Ovary Cell Line by Targeted RNA Sequencing.
Siyan Zhang, Jason D Hughes, Nicholas Murgolo, Diane Levitan, Janice Chen

Biomed Res Int· December 2016

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Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.
Jonathan J Lyons, Xiaomin Yu, Jason D Hughes, Quang T Le, Ali Jamil

Nat Genet· December 2016

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AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.
Bernice Lo, Kejian Zhang, Wei Lu, Lixin Zheng, Qian Zhang, Jason D Hughes

Science· July 2015

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Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations.
Joshua D Milner, Tiphanie P Vogel, Lisa Forbes, Chi A Ma, Asbjørg Stray-Pedersen, Jason D Hughes

Blood· January 2015

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Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment.
Yu Zhang, Xiaomin Yu, Mie Ichikawa, Jonathan J Lyons, Shrimati Datta, Jason D Hughes

J Allergy Clin Immunol· May 2014

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siRNA off-target effects can be reduced at concentrations that match their individual potency.
Daniel R Caffrey, Juan Zhao, Zhili Song, Michael E Schaffer, Steven A Haney, Jason D Hughes

PLoS One· December 2011

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Physiochemical drug properties associated with in vivo toxicological outcomes.
Jason D Hughes, Julian Blagg, David A Price, Simon Bailey, Gary A Decrescenzo

Bioorg Med Chem Lett· September 2008

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Are protein-protein interfaces more conserved in sequence than the rest of the protein surface?
Daniel R Caffrey, Shyamal Somaroo, Jason D Hughes, Julian Mintseris, Enoch S Huang

Protein Sci· January 2004

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