Publications by authors named "Debra Pittman"

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Marstacimab, an antitissue factor pathway inhibitor, combined with bypassing agents: effects on thrombin generation and in hemostatically normal rats.
Marjorie A Peraza, Swapnil Rakhe, Susan Hurst, Madhu Sirivelu, Karrie Brenneman, Debra D Pittman

Res Pract Thromb Haemost· October 2025

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Field Study and Correlative Studies of Factor IX Variant FIX-R338L in Participants Treated with Fidanacogene Elaparvovec.
Debra D Pittman, Charles Carrieri, Holly Soares, John McKay, Charles Y Tan

Thromb Haemost· October 2024

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To Clot or Not to Clot: Deepening Our Understanding of Alterations in the Hemostatic System.
William J Reagan, Marjory B Brooks, Renata Grozovsky, Debra Pittman, Allison Vitsky

Toxicol Pathol· October 2022

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Validation of patient-reported vaso-occlusive crisis day as an endpoint in sickle cell disease studies.
Karin S Coyne, Brooke M Currie, Michael Callaghan, Kathleen W Wyrwich, Sheryl Pease, Debra D Pittman

Eur J Haematol· September 2022

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Hemostatic efficacy of marstacimab alone or in combination with bypassing agents in hemophilia plasmas and a mouse bleeding model.
Debra D Pittman, Swapnil Rakhe, Sheryl R Bowley, Reema Jasuja, Amey Barakat

Res Pract Thromb Haemost· February 2022

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Evaluation of Longitudinal Pain Study in Sickle Cell Disease (ELIPSIS) by patient-reported outcomes, actigraphy, and biomarkers.
Debra D Pittman, Patrick C Hines, David Beidler, Denis Rybin, Andrew L Frelinger

Blood· April 2021

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Investigating the clearance of VWF A-domains using site-directed PEGylation and novel N-linked glycosylation.
Judicael Fazavana, Teresa M Brophy, Alain Chion, Niamh Cooke, Virginie Terraube, Debra Pittman

J Thromb Haemost· June 2020

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Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia.
João Arezes, Niall Foy, Kirsty McHugh, Doris Quinkert, Susan Benard, Debra D Pittman

Blood· February 2020

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Marstacimab, a tissue factor pathway inhibitor neutralizing antibody, improves coagulation parameters of ex vivo dosed haemophilic blood and plasmas.
Sunita Patel-Hett, Erika J Martin, Bassem M Mohammed, Swapnil Rakhe, Pengling Sun, Debra D Pittman

Haemophilia· September 2019

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Induction and Impact of Anti-Drug Responses Elicited by a Human Recombinant Coagulation Factor FXa in Preclinical Species.
Chuenlei Parng, Michael Bolt, Debra D Pittman, Teresa Caiazzo, Lisa Dyleski

AAPS J· April 2019

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PF-04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo-Controlled Study.
Robert J Charnigo, David Beidler, Denis Rybin, Debra D Pittman, Beesan Tan

Clin Transl Sci· March 2019

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Translational Pharmacokinetic/Pharmacodynamic Characterization and Target-Mediated Drug Disposition Modeling of an Anti-Tissue Factor Pathway Inhibitor Antibody, PF-06741086.
Chuenlei Parng, Pratap Singh, Debra D Pittman, Katherine Wright, Beth Leary

J Pharm Sci· July 2018

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Preclinical Pharmacokinetics, Pharmacodynamics, Tissue Distribution, and Interspecies Scaling of Recombinant Human Coagulation Factor Xa.
Chuenlei Parng, Victoria Markiewicz, Jianqing Chen, Beth Leary, Nicole Duriga, Debra D Pittman

J Pharm Sci· August 2017

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A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia.
Lacramioara Ivanciu, Raffaella Toso, Paris Margaritis, Giulia Pavani, Haein Kim, Debra D Pittman

Nat Biotechnol· October 2011

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Inhibition of the Unfolded Protein Response by metformin in renal proximal tubular epithelial cells.
Jimmy R Thériault, Helen J Palmer, Debra D Pittman

Biochem Biophys Res Commun· June 2011

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A monoclonal antibody against RAGE alters gene expression and is protective in experimental models of sepsis and pneumococcal pneumonia.
Eirini Christaki, Steven M Opal, James C Keith, Nubar Kessimian, John E Palardy, Debra D Pittman

Shock· May 2011

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Pharmacokinetics and lung distribution of a humanized anti-RAGE antibody in wild-type and RAGE-/- mice.
Yulia Vugmeyster, David DeFranco, Debra D Pittman, Xin Xu

MAbs· April 2011

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IL-22 induces an acute-phase response.
Spencer C Liang, Cheryl Nickerson-Nutter, Debra D Pittman, Yijun Carrier, Debra G Goodwin

J Immunol· November 2010

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Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-α production in a receptor for advanced glycation end product-dependent manner.
Benfang Helen Ruan, Xin Li, Aaron R Winkler, Kristina M Cunningham, Jun Kuai, Debra D Pittman

J Immunol· October 2010

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TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.
Jun Kuai, Bernard Gregory, Andrew Hill, Debra D Pittman, Jeffrey L Feldman

Rheumatology (Oxford)· November 2009

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Affinity maturation of a humanized rat antibody for anti-RAGE therapy: comprehensive mutagenesis reveals a high level of mutational plasticity both inside and outside the complementarity-determining regions.
William J Finlay, Orla Cunningham, Matthew A Lambert, Alfredo Darmanin-Sheehan, Xuemei Liu, Debra D Pittman

J Mol Biol· May 2009

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Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis.
Valerie Clerin, Heather H Shih, Nanhua Deng, Gustave Hebert, Christine Resmini, Debra D Pittman

Atherosclerosis· November 2008

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Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection.
Emily C Lutterloh, Steven M Opal, Debra D Pittman, James C Keith, Xiang-Yang Tan

Crit Care· April 2008

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Proteomic identification of endothelial proteins isolated in situ from atherosclerotic aorta via systemic perfusion.
Jiang Wu, Wei Liu, Eric Sousa, Yongchang Qiu, Debra D Pittman

J Proteome Res· December 2007

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Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis.
Christopher J Edwards, Jeffrey L Feldman, Jonathan Beech, Kathleen M Shields, Jennifer A Stover, Debra D Pittman

Mol Med· July 2007

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