Publications by authors named "Deepa Ajit"

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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome.
Kira A Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Deepa Ajit

Elife· February 2025

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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome.
Kira Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Deepa Ajit

bioRxiv· November 2024

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Metabolomic comparison of postprandial distress syndrome patients with and without duodenal eosinophilia.
Stuti Dalal, Deepa Ajit, Chance S Friesen, Valentina Shakhnovich, Meenal Singh

J Pediatr Gastroenterol Nutr· November 2024

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RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy.
Julie C Necarsulmer, Jeremy M Simon, Baggio A Evangelista, Youjun Chen, Xu Tian, Deepa Ajit

Elife· October 2023

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Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A.
Blake A Creighton, Simone Afriyie, Deepa Ajit, Cristine R Casingal, Kayleigh M Voos

Elife· November 2021

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Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome.
Margot A Cousin, Blake A Creighton, Keith A Breau, Rebecca C Spillmann, Erin Torti, Deepa Ajit

Nat Genet· July 2021

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An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline.
Hanna Trzeciakiewicz, Deepa Ajit, Jui-Heng Tseng, Youjun Chen, Aditi Ajit

Nat Commun· November 2020

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A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation.
Deepa Ajit, Hanna Trzeciakiewicz, Jui-Heng Tseng, Connor M Wander, Youjun Chen, Aditi Ajit

J Biol Chem· November 2019

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The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology.
Jui-Heng Tseng, Ling Xie, Sheng Song, Youmei Xie, Lauren Allen, Deepa Ajit

Cell Rep· August 2017

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Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in DI TNC1 astrocytes.
Deepa Ajit, Agnes Simonyi, Runting Li, Zihong Chen, Mark Hannink

Neurochem Int· July 2016

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Purinergic receptors as potential therapeutic targets in Alzheimer's disease.
Lucas T Woods, Deepa Ajit, Jean M Camden, Laurie Erb, Gary A Weisman

Neuropharmacology· May 2016

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Beneficial effects of dietary EGCG and voluntary exercise on behavior in an Alzheimer's disease mouse model.
Jennifer M Walker, Diana Klakotskaia, Deepa Ajit, Gary A Weisman, W Gibson Wood

J Alzheimers Dis· September 2015

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P2Y receptors in Alzheimer's disease.
Laurie Erb, Chen Cao, Deepa Ajit, Gary A Weisman

Biol Cell· January 2015

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Loss of P2Y₂ nucleotide receptors enhances early pathology in the TgCRND8 mouse model of Alzheimer's disease.
Deepa Ajit, Lucas T Woods, Jean M Camden, Christina N Thebeau, Farid G El-Sayed

Mol Neurobiol· April 2014

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Up-regulation and activation of the P2Y(2) nucleotide receptor mediate neurite extension in IL-1β-treated mouse primary cortical neurons.
Troy S Peterson, Christina N Thebeau, Deepa Ajit, Jean M Camden, Lucas T Woods

J Neurochem· June 2013

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Neuroprotective roles of the P2Y(2) receptor.
Gary A Weisman, Deepa Ajit, Richard Garrad, Troy S Peterson, Lucas T Woods

Purinergic Signal· September 2012

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P2 receptors for extracellular nucleotides in the central nervous system: role of P2X7 and P2Y₂ receptor interactions in neuroinflammation.
Gary A Weisman, Jean M Camden, Troy S Peterson, Deepa Ajit, Lucas T Woods

Mol Neurobiol· August 2012

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Nucleotides released from Aβ₁₋₄₂ -treated microglial cells increase cell migration and Aβ₁₋₄₂ uptake through P2Y₂ receptor activation.
Hye Jung Kim, Deepa Ajit, Troy S Peterson, Yanfang Wang, Jean M Camden

J Neurochem· April 2012

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Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA₂-IIA expression in astrocytes and microglia.
Wenwen Sheng, Yijia Zong, Arwa Mohammad, Deepa Ajit, Jiankun Cui

J Neuroinflammation· September 2011

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Probing the amyloid-beta(1-40) fibril environment with substituted tryptophan residues.
Jillienne C Touchette, Laura L Williams, Deepa Ajit, Fabio Gallazzi, Michael R Nichols

Arch Biochem Biophys· February 2010

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Amyloid-beta(1-42) fibrillar precursors are optimal for inducing tumor necrosis factor-alpha production in the THP-1 human monocytic cell line.
Deepa Ajit, Maria L D Udan, Geeta Paranjape, Michael R Nichols

Biochemistry· September 2009

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Oligomeric amyloid-beta(1-42) induces THP-1 human monocyte adhesion and maturation.
Nikkilina R Crouse, Deepa Ajit, Maria L D Udan, Michael R Nichols

Brain Res· February 2009

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Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line.
Maria L D Udan, Deepa Ajit, Nikkilina R Crouse, Michael R Nichols

J Neurochem· January 2008

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