Publications by authors named "Delphine Launay"

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Mass balance, pharmacokinetics, metabolism, and excretion of radiolabeled acoziborole, a potential novel treatment for human African trypanosomiasis, following single microtracer oral dose to humans.
Jean-Yves Gillon, François Simon, Sharan Sidhu, Mathieu Louis, Delphine Launay

Antimicrob Agents Chemother· November 2025

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Safety, tolerability and pharmacokinetics of DNDI-6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants.
Jean-Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard

Br J Clin Pharmacol· November 2025

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Novel Linker Variants of Antileishmanial/Antitubercular 7-Substituted 2-Nitroimidazooxazines Offer Enhanced Solubility.
Andrew M Thompson, Patrick D O'Connor, Vanessa Yardley, Louis Maes, Delphine Launay

ACS Med Chem Lett· February 2021

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Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal.
Andrew M Thompson, Patrick D O'Connor, Andrew J Marshall, Vanessa Yardley, Louis Maes, Delphine Launay

Eur J Med Chem· January 2021

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Development and validation of LC-MS/MS method for determination of DNDI-VL-2098 in mouse, rat, dog and hamster blood.
Bhavesh D Patel, Ritika Uppal, Nageswararao Pulakundam, Jignesh P Patel, Vikram Ramanathan, Delphine Launay

Bioanalysis· August 2019

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Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.
Andrew M Thompson, Patrick D O'Connor, Andrew J Marshall, Adrian Blaser, Vanessa Yardley, Delphine Launay

J Med Chem· March 2018

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Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.
Andrew M Thompson, Andrew J Marshall, Louis Maes, Nigel Yarlett, Cyrus J Bacchi, Delphine Launay

Bioorg Med Chem Lett· January 2018

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6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases.
Andrew M Thompson, Adrian Blaser, Brian D Palmer, Robert F Anderson, Sujata S Shinde, Delphine Launay

Bioorg Med Chem Lett· June 2017

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7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis.
Andrew M Thompson, Patrick D O'Connor, Andrew J Marshall, Vanessa Yardley, Louis Maes, Delphine Launay

J Med Chem· May 2017

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Development of a Scalable Process for the Synthesis of DNDI-VL-2098: A Potential Preclinical Drug Candidate for the Treatment of Visceral Leishmaniasis.
Vijay S Satam, Srinivasa Rao Pedada, Pasumpon Kamaraj, Nakita Antao, Apoorva Singh, Delphine Launay

Org Process Res Dev· January 2017

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Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis.
Andrew M Thompson, Patrick D O'Connor, Adrian Blaser, Vanessa Yardley, Louis Maes, Delphine Launay

J Med Chem· March 2016

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Aminothiazoles: Hit to lead development to identify antileishmanial agents.
Debnath Bhuniya, Rao Mukkavilli, Rahul Shivahare, Delphine Launay, Ravindra T Dere

Eur J Med Chem· September 2015

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Nitroimidazo-oxazole compound DNDI-VL-2098: an orally effective preclinical drug candidate for the treatment of visceral leishmaniasis.
Suman Gupta, Vanessa Yardley, Preeti Vishwakarma, Rahul Shivahare, Bhawna Sharma, Delphine Launay

J Antimicrob Chemother· February 2015

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In vitro metabolism, disposition, preclinical pharmacokinetics and prediction of human pharmacokinetics of DNDI-VL-2098, a potential oral treatment for Visceral Leishmaniasis.
Rao Mukkavilli, Jakir Pinjari, Bhavesh Patel, Shankar Sengottuvelan, Subodh Mondal, Delphine Launay

Eur J Pharm Sci· December 2014

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Design, synthesis, ADME characterization and antileishmanial evaluation of novel substituted quinoline analogs.
Vadiraj S Gopinath, Mukkavilli Rao, Rahul Shivahare, Preeti Vishwakarma, Sweta Ghose, Delphine Launay

Bioorg Med Chem Lett· May 2014

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Design, synthesis and biological evaluation of 2-substituted quinolines as potential antileishmanial agents.
Vadiraj S Gopinath, Jakir Pinjari, Ravindra T Dere, Aditya Verma, Preeti Vishwakarma, Delphine Launay

Eur J Med Chem· November 2013

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High throughput physical organic chemistry: analytical constructs for monomer reactivity profiling.
Christophe Portal, Delphine Launay, Andrew Merritt, Mark Bradley

J Comb Chem· February 2006

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Microwaves, supported-reagents and parallel synthesis: isocyanide and ester synthesis.
Stefano Crosignani, Delphine Launay, Bruno Linclau, Mark Bradley

Mol Divers· September 2004

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