Publications by authors named "Patrick D O'Connor"

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Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors.
Kate H Gartlan, Jagdish K Jaiswal, Matthew R Bull, Hedieh Akhlaghi, Vivien R Sutton, Patrick D O'Connor

ACS Pharmacol Transl Sci· June 2022

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Novel Linker Variants of Antileishmanial/Antitubercular 7-Substituted 2-Nitroimidazooxazines Offer Enhanced Solubility.
Andrew M Thompson, Patrick D O'Connor, Vanessa Yardley, Louis Maes, Delphine Launay

ACS Med Chem Lett· February 2021

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Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal.
Andrew M Thompson, Patrick D O'Connor, Andrew J Marshall, Vanessa Yardley, Louis Maes

Eur J Med Chem· January 2021

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Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy.
Andrew M Thompson, Patrick D O'Connor, Andrew J Marshall, Amanda F Francisco, John M Kelly

Eur J Med Chem· December 2020

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Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo.
Julie A Spicer, Christian K Miller, Patrick D O'Connor, Jiney Jose, Anna C Giddens

J Med Chem· March 2020

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Synthesis and Evaluation of Imidazo[1,2-a]pyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3-Kinase Inhibitors.
Swarna A Gamage, Julie A Spicer, Kit Y Tsang, Patrick D O'Connor, Jack U Flanagan

Chem Asian J· April 2019

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Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.
Andrew M Thompson, Patrick D O'Connor, Andrew J Marshall, Adrian Blaser, Vanessa Yardley

J Med Chem· March 2018

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Substituted arylsulphonamides as inhibitors of perforin-mediated lysis.
Julie A Spicer, Christian K Miller, Patrick D O'Connor, Jiney Jose, Kristiina M Huttunen

Eur J Med Chem· September 2017

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7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis.
Andrew M Thompson, Patrick D O'Connor, Andrew J Marshall, Vanessa Yardley, Louis Maes

J Med Chem· May 2017

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Benzenesulphonamide inhibitors of the cytolytic protein perforin.
Julie A Spicer, Christian K Miller, Patrick D O'Connor, Jiney Jose, Kristiina M Huttunen

Bioorg Med Chem Lett· February 2017

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Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis.
Andrew M Thompson, Patrick D O'Connor, Adrian Blaser, Vanessa Yardley, Louis Maes

J Med Chem· March 2016

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Mechanism of action of AminoCBIs: highly reactive but highly cytotoxic analogues of the duocarmycins.
Moana Tercel, Frederik B Pruijn, Patrick D O'Connor, H D Sarath Liyanage, Graham J Atwell

Chembiochem· September 2014

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Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin.
Julie A Spicer, Gersande Lena, Dani M Lyons, Kristiina M Huttunen, Christian K Miller, Patrick D O'Connor

J Med Chem· December 2013

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Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis.
Gamma Chi, Alexandra Manos-Turvey, Patrick D O'Connor, Jodie M Johnston, Genevieve L Evans

Biochemistry· June 2012

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Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors.
Jackie D Kendall, Patrick D O'Connor, Andrew J Marshall, Raphaël Frédérick, Elaine S Marshall

Bioorg Med Chem· January 2012

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Synthesis and reactivity of beta-methoxymethyl enecarbamates.
Patrick D O'Connor, Michael G Marino, Stéphanie M Guéret, Margaret A Brimble

J Org Chem· November 2009

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Synthesis of enantiopure bicyclic alpha,alpha-disubstituted spirolactams via asymmetric Birch reductive alkylation.
Stéphanie M Guéret, Patrick D O'Connor, Margaret A Brimble

Org Lett· February 2009

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Appraisals of pain from controlled stimuli: relevance to quantitative sensory testing.
Erin A Dannecker, Donald D Price, Patrick D O'Connor, Michael E Robinson

Br J Health Psychol· September 2008

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Predicting absorption and dispersion in acoustics by direct simulation Monte Carlo: Quantum and classical models for molecular relaxation.
Amanda D Hanford, Patrick D O'Connor, James B Anderson, Lyle N Long

J Acoust Soc Am· June 2008

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(1R,6R)-1-Methyl-8-aza-spiro-[5.6]dodecan-7-one.
Stéphanie M Guéret, Ka Wai Choi, Patrick D O'Connor, Peter D W Boyd, Margaret A Brimble

Acta Crystallogr Sect E Struct Rep Online· May 2008

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Synthesis of macrocyclic shellfish toxins containing spiroimine moieties.
Patrick D O'Connor, Margaret A Brimble

Nat Prod Rep· August 2007

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Pectenotoxin-2 synthetic studies. 3. Assessment of the capacity for stereocontrolled cyclization to form the entire C1-C26 subunit based upon the double bond geometry across C15-C16.
Patrick D O'Connor, Christopher K Knight, Dirk Friedrich, Xiaowen Peng, Leo A Paquette

J Org Chem· March 2007

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Effect of eccentric strength testing on delayed-onset muscle pain.
Erin A Dannecker, Patrick D O'Connor, James W Atchison, Michael E Robinson

J Strength Cond Res· November 2005

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Synthesis of the himandrine skeleton.
Patrick D O'Connor, Lewis N Mander, Matthew M W McLachlan

Org Lett· March 2004

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