Publications by authors named "Frederik B Pruijn"

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Clinical relevance and therapeutic predictive ability of hypoxia biomarkers in head and neck cancer tumour models.
Tet Woo Lee, Dean C Singleton, Julia K Harms, Man Lu, Sarah P McManaway, Frederik B Pruijn

Mol Oncol· August 2024

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Spatially-resolved pharmacokinetic/pharmacodynamic modelling of bystander effects of a nitrochloromethylbenzindoline hypoxia-activated prodrug.
Cho Rong Hong, Sunali Y Mehta, H D Sarath Liyanage, Sarah P McManaway, Ho H Lee, Frederik B Pruijn

Cancer Chemother Pharmacol· October 2021

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Engineering the Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System.
Abigail V Sharrock, Sarah P McManaway, Michelle H Rich, Jeff S Mumm, Ian F Hermans, Frederik B Pruijn

Front Pharmacol· June 2021

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Cellular pharmacology of evofosfamide (TH-302): A critical re-evaluation of its bystander effects.
Cho Rong Hong, Benjamin D Dickson, Jagdish K Jaiswal, Frederik B Pruijn, Francis W Hunter

Biochem Pharmacol· October 2018

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Bystander Effects of Hypoxia-Activated Prodrugs: Agent-Based Modeling Using Three Dimensional Cell Cultures.
Cho R Hong, Gib Bogle, Jingli Wang, Kashyap Patel, Frederik B Pruijn

Front Pharmacol· September 2018

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Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides.
Muriel Bonnet, Cho Rong Hong, Way Wua Wong, Lydia P Liew, Avik Shome, Frederik B Pruijn

J Med Chem· February 2018

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Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.
Yongchuan Gu, Tony T-A Chang, Jingli Wang, Jagdish K Jaiswal, David Edwards, Frederik B Pruijn

Front Pharmacol· August 2017

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Influence of a Basic Side Chain on the Properties of Hypoxia-Selective Nitro Analogues of the Duocarmycins: Demonstration of Substantial Anticancer Activity in Combination with Irradiation or Chemotherapy.
Moana Tercel, Ho H Lee, Sunali Y Mehta, Jean-Jacques Youte Tendoung, Sally Y Bai, Frederik B Pruijn

J Med Chem· July 2017

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Preparation and properties of clickable amino analogues of the duocarmycins: factors that affect the efficiency of their fluorescent labelling of DNA.
Moana Tercel, Sarah P McManaway, H D Sarath Liyanage, Frederik B Pruijn

ChemMedChem· September 2014

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Mechanism of action of AminoCBIs: highly reactive but highly cytotoxic analogues of the duocarmycins.
Moana Tercel, Frederik B Pruijn, Patrick D O'Connor, H D Sarath Liyanage, Graham J Atwell

Chembiochem· September 2014

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The flavoprotein FOXRED2 reductively activates nitro-chloromethylbenzindolines and other hypoxia-targeting prodrugs.
Francis W Hunter, Jagdish K Jaiswal, Daniel G Hurley, H D Sarath Liyanage, Sarah P McManaway, Frederik B Pruijn

Biochem Pharmacol· May 2014

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Novel nitroimidazole alkylsulfonamides as hypoxic cell radiosensitisers.
Muriel Bonnet, Cho Rong Hong, Yongchuan Gu, Robert F Anderson, William R Wilson, Frederik B Pruijn

Bioorg Med Chem· April 2014

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Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence.
Jiechuang Su, Yongchuan Gu, Frederik B Pruijn, Jeff B Smaill, Adam V Patterson

J Biol Chem· December 2013

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The cytotoxicity of duocarmycin analogues is mediated through alkylation of DNA, not aldehyde dehydrogenase 1: a comment.
Moana Tercel, Sarah P McManaway, Euphemia Leung, H D Sarath Liyanage, Guo-Liang Lu, Frederik B Pruijn

Angew Chem Int Ed Engl· May 2013

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Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy.
Ralph J Stevenson, William A Denny, Moana Tercel, Frederik B Pruijn, Amir Ashoorzadeh

J Med Chem· March 2012

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Preparation and antitumour properties of the enantiomers of a hypoxia-selective nitro analogue of the duocarmycins.
Moana Tercel, Ho H Lee, Shangjin Yang, H D Sarath Liyanage, Sunali Y Mehta, Frederik B Pruijn

ChemMedChem· October 2011

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The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy.
Ralph J Stevenson, William A Denny, Amir Ashoorzadeh, Frederik B Pruijn, Wouter F van Leeuwen

Bioorg Med Chem· October 2011

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The effect of sulfonate leaving groups on the hypoxia-selective toxicity of nitro analogs of the duocarmycins.
Amir Ashoorzadeh, Graham J Atwell, Frederik B Pruijn, William R Wilson, Moana Tercel

Bioorg Med Chem· August 2011

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Selective treatment of hypoxic tumor cells in vivo: phosphate pre-prodrugs of nitro analogues of the duocarmycins.
Moana Tercel, Graham J Atwell, Shangjin Yang, Amir Ashoorzadeh, Ralph J Stevenson, Frederik B Pruijn

Angew Chem Int Ed Engl· March 2011

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Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors.
Kevin O Hicks, Bronwyn G Siim, Jagdish K Jaiswal, Frederik B Pruijn, Annie M Fraser

Clin Cancer Res· October 2010

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Hypoxic selectivity and solubility--investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy.
Moana Tercel, Shangjin Yang, Graham J Atwell, Eileen Smith, Yongchuan Gu, Frederik B Pruijn

Bioorg Med Chem· July 2010

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Hypoxia-activated prodrugs: substituent effects on the properties of nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) prodrugs of DNA minor groove alkylating agents.
Moana Tercel, Graham J Atwell, Shangjin Yang, Ralph J Stevenson, K Jane Botting, Frederik B Pruijn

J Med Chem· November 2009

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Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N3 DNA minor groove alkylators.
William R Wilson, Stephen M Stribbling, Frederik B Pruijn, Sophie P Syddall, Adam V Patterson

Mol Cancer Ther· October 2009

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Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins.
Michael P Hay, Kevin O Hicks, Karin Pchalek, Ho H Lee, Adrian Blaser, Frederik B Pruijn

J Med Chem· November 2008

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Hypoxia-selective 3-alkyl 1,2,4-benzotriazine 1,4-dioxides: the influence of hydrogen bond donors on extravascular transport and antitumor activity.
Michael P Hay, Karin Pchalek, Frederik B Pruijn, Kevin O Hicks, Bronwyn G Siim

J Med Chem· December 2007

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