Publications by authors named "Denis Schewe"

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Cell cycle regulator MYBL2 is a distinct vulnerability in acute myeloid leukemia.
Sandra Küchler, Silke Brilloff, Silvia Schäfer, Elahe Rahimian, Vida Kufrin, Denis M Schewe

Cell Death Discov· October 2025

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A quiescence-like/TGF-β1-specific CRISPRi screen reveals drug uptake transporters as secondary targets of kinase inhibitors in AML.
Elahe Rahimian, Masoud Koochak, Sofia Traikov, Michael Schroeder, Silke Brilloff, Denis M Schewe

Drug Resist Updat· July 2025

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Two is better than one: dual targeting of WDR5 in T-ALL.
Alexander A Wurm, Denis M Schewe

Blood· March 2025

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A brain organoid/ALL coculture model reveals the AP-1 pathway as critically associated with CNS involvement of BCP-ALL.
Philip Gebing, Stefanos Loizou, Sebastian Hänsch, Julian Schliehe-Diecks, Lea Spory, Denis M Schewe

Blood Adv· October 2024

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The IL-7R antagonist lusvertikimab reduces leukemic burden in xenograft ALL via antibody-dependent cellular phagocytosis.
Lennart Lenk, Irène Baccelli, Anna Laqua, Julia Heymann, Claas Reimer, Denis M Schewe

Blood· June 2024

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Enhanced potency of immunotherapy against B-cell precursor acute lymphoblastic leukemia by combination of an Fc-engineered CD19 antibody and CD47 blockade.
Denis M Schewe, Fotini Vogiatzi, Ira A Münnich, Tobias Zeller, Roland Windisch

Hemasphere· February 2024

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Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome.
Anna S Kolodziejczak, Lea Guerrini-Rousseau, Julien Masliah Planchon, Jonas Ecker, Florian Selt, Denis M Schewe

Neuro Oncol· December 2023

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Recurrent DNMT3B rearrangements are associated with unfavorable outcome in dicentric (9;20)-positive pediatric BCP-ALL.
Željko Antić, Alena van Bömmel, Konstantin Riege, Jana Lentes, Charlotte Schröder, Denis M Schewe

Leukemia· December 2023

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Perspectives of targeting LILRB1 in innate and adaptive immune checkpoint therapy of cancer.
Tobias Zeller, Ira A Münnich, Roland Windisch, Patricia Hilger, Denis M Schewe

Front Immunol· October 2023

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AP-1 Transcription Factor Complex Members and are Linked With CNS Infiltration and Inferior Prognosis in Childhood T-ALL.
Lea Spory, Johannes Zimmermann, Michaela Vossen-Gajcy, Thomas Beder, Lorenz Bastian, Denis M Schewe

Hemasphere· September 2023

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Molecular complete remission following combination treatment of daratumumab and venetoclax in an adolescent with relapsed mixed phenotype acute leukemia.
Martin Stanulla, Denis M Schewe, Beat Bornhauser, Jean-Pierre Bourquin, Cornelia Eckert

Ann Hematol· March 2023

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Accumulation of T-cell-suppressive PD-L1 extracellular vesicles is associated with GvHD and might impact GvL efficacy.
Rebecca Baur, Franziska Karl, Romy Böttcher-Loschinski, Andrej Stoll, Simon Völkl, Denis M Schewe

J Immunother Cancer· March 2023

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Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML).
Sophie Steinhäuser, Patricia Silva, Lennart Lenk, Thomas Beder, Alina Hartmann, Denis Martin Schewe

Leukemia· January 2023

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Outcome for Pediatric Adreno-Cortical Tumors Is Best Predicted by the COG Stage and Five-Item Microscopic Score-Report from the German MET Studies.
Michaela Kuhlen, Marina Kunstreich, Stefan A Wudy, Paul-Martin Holterhus, Lienhard Lessel, Denis M Schewe

Cancers (Basel)· December 2022

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Dual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages.
Tobias Zeller, Sebastian Lutz, Ira A Münnich, Roland Windisch, Patricia Hilger, Denis M Schewe

Front Immunol· November 2022

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Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia.
Ricky Tirtakusuma, Katarzyna Szoltysek, Paul Milne, Vasily V Grinev, Anetta Ptasinska, Denis Schewe

Blood· October 2022

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Key factors for effective mitotane therapy in children with adrenocortical carcinoma.
Michaela Kuhlen, Pascal Mier, Marina Kunstreich, Lienhard Lessel, Dominik Schneider, Denis M Schewe

Endocr Relat Cancer· September 2022

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Myeloid checkpoint blockade improves killing of T-acute lymphoblastic leukemia cells by an IgA2 variant of daratumumab.
Niklas Baumann, Christian Arndt, Judith Petersen, Marta Lustig, Thies Rösner, Denis M Schewe

Front Immunol· September 2022

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Dual Fc optimization to increase the cytotoxic activity of a CD19-targeting antibody.
Carina Lynn Gehlert, Pegah Rahmati, Ammelie Svea Boje, Dorothee Winterberg, Steffen Krohn, Denis Martin Schewe

Front Immunol· September 2022

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Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies by augmenting tumor cell phagocytosis.
Fotini Vogiatzi, Julia Heymann, Kristina Müller, Dorothee Winterberg, Aneta Drakul, Denis M Schewe

Blood Adv· August 2022

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Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B-cell Precursor Acute Lymphoblastic Leukemia.
Lennart Lenk, Dorothee Winterberg, Fotini Vogiatzi, Anna Laqua, Lea Spory, Denis M Schewe

Hemasphere· August 2022

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Combining daratumumab with CD47 blockade prolongs survival in preclinical models of pediatric T-ALL.
Kristina Müller, Fotini Vogiatzi, Dorothee Winterberg, Thies Rösner, Lennart Lenk, Denis M Schewe

Blood· July 2022

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High BMP4 expression in low/intermediate risk BCP-ALL identifies children with poor outcomes.
Lidia M Fernández-Sevilla, Jaris Valencia, Paula Ortiz-Sánchez, Alberto Fraile-Ramos, Pilar Zuluaga, Denis Schewe

Blood· June 2022

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Transcriptional and Mutational Profiling of B-Other Acute Lymphoblastic Leukemia for Improved Diagnostics.
Philippe Chouvarine, Željko Antić, Jana Lentes, Charlotte Schröder, Julia Alten, Denis Schewe

Cancers (Basel)· November 2021

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In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets.
Michela Carlet, Kerstin Völse, Jenny Vergalli, Martin Becker, Tobias Herold, Denis M Schewe

Nat Commun· September 2021

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