Publications by authors named "Dennis Wegener"

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Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes.
Tim J Wigle, W David Church, Christina R Majer, Kerren K Swinger, Demet Aybar, Dennis Wegener

SLAS Discov· March 2020

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Roman C Hillig, Brice Sautier, Jens Schroeder, Dieter Moosmayer, André Hilpmann, Dennis Wegener

Proc Natl Acad Sci U S A· February 2019

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Workflows for intelligent monitoring using proxy services.
Stefan Rüping, Dennis Wegener, Stelios Sfakianakis, Thierry Sengstag

Stud Health Technol Inform· September 2009

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Histone deacetylase 8 in neuroblastoma tumorigenesis.
Ina Oehme, Hedwig E Deubzer, Dennis Wegener, Diana Pickert, Jan-Peter Linke

Clin Cancer Res· January 2009

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HKI 46F08, a novel potent histone deacetylase inhibitor, exhibits antitumoral activity against embryonic childhood cancer cells.
Dennis Wegener, Hedwig E Deubzer, Ina Oehme, Till Milde, Christian Hildmann

Anticancer Drugs· October 2008

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Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorigenic assay.
Dennis Wegener, Christian Hildmann, Daniel Riester, Andreas Schober, Franz-Josef Meyer-Almes

Biochem J· July 2008

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Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor.
Tine Kragh Nielsen, Christian Hildmann, Daniel Riester, Dennis Wegener, Andreas Schwienhorst

Acta Crystallogr Sect F Struct Biol Cryst Commun· April 2007

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An active site tyrosine residue is essential for amidohydrolase but not for esterase activity of a class 2 histone deacetylase-like bacterial enzyme.
Kristin Moreth, Daniel Riester, Christian Hildmann, René Hempel, Dennis Wegener

Biochem J· February 2007

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Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases.
Christian Hildmann, Dennis Wegener, Daniel Riester, René Hempel, Andreas Schober

J Biotechnol· June 2006

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Recent progress in the development of assays suited for histone deacetylase inhibitor screening.
Dennis Wegener, Christian Hildmann, Andreas Schwienhorst

Mol Genet Metab· November 2004

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Members of the histone deacetylase superfamily differ in substrate specificity towards small synthetic substrates.
Daniel Riester, Dennis Wegener, Christian Hildmann, Andreas Schwienhorst

Biochem Biophys Res Commun· November 2004

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A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases.
Christian Hildmann, Milena Ninkovic, Rüdiger Dietrich, Dennis Wegener, Daniel Riester

J Bacteriol· April 2004

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Improved fluorogenic histone deacetylase assay for high-throughput-screening applications.
Dennis Wegener, Christian Hildmann, Daniel Riester, Andreas Schwienhorst

Anal Biochem· October 2003

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A fluorogenic histone deacetylase assay well suited for high-throughput activity screening.
Dennis Wegener, Frank Wirsching, Daniel Riester, Andreas Schwienhorst

Chem Biol· January 2003

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