Publications by authors named "Derek Le"

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3D genetic architecture of schizophrenia risk across three neuronal subtypes.
Samuel K Powell, Will Liao, Sadaf Ghorbani, Raymond Rigat, Callan O'Shea, Derek J Le

Mol Psychiatry· November 2025

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Super-enhancer interactomes from single cells link clustering and transcription.
Derek J Le, Antonina Hafner, Sadhana Gaddam, Kevin C Wang, Alistair N Boettiger

bioRxiv· May 2024

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Single-cell chromatin state transitions during epigenetic memory formation.
Taihei Fujimori, Carolina Rios-Martinez, Abby R Thurm, Michaela M Hinks, Benjamin R Doughty, Derek Le, William J Greenleaf

bioRxiv· October 2023

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Schizophrenia Risk Mapping and Functional Engineering of the 3D Genome in Three Neuronal Subtypes.
Samuel K Powell, Will Liao, Callan O'Shea, Sarah Kammourh, Sadaf Ghorbani, Derek J Le

bioRxiv· July 2023

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Human cortical interneurons optimized for grafting specifically integrate, abort seizures, and display prolonged efficacy without over-inhibition.
Qian Zhu, Akanksha Mishra, Joy S Park, Dongxin Liu, Derek T Le, Sasha Z Gonzalez, Xiao-Lei Zhang, Christopher S Leonard

Neuron· March 2023

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Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion.
Christopher D Ma, Michio Imamura, Daniel C Talley, Adam Rolt, Xin Xu, Derek Le

Nat Microbiol· December 2020

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Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia.
Gun-Hoo Park, Haneul Noh, Zhicheng Shao, Peiyan Ni, Yiren Qin, Derek T Le, Sasha Z Gonzalez, Joseph T Coyle

Nat Neurosci· November 2020

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Discovery and characterization of a novel HCV inhibitor targeting the late stage of HCV life cycle.
Seung Bum Park, Audrey Boyer, Zongyi Hu, Derek Le, T Jake Liang

Antivir Ther· July 2020

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Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1.
Zongyi Hu, Adam Rolt, Xin Hu, Christopher D Ma, Derek J Le, Daniel C Talley

Cell Chem Biol· July 2020

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Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.
Adam Rolt, Derek Le, Zongyi Hu, Amy Q Wang, Pranav Shah, Marc Singleton

J Infect Dis· May 2018

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Whole Exome Sequencing and Segregation Analysis Confirms That a Mutation in COL17A1 Is the Cause of Epithelial Recurrent Erosion Dystrophy in a Large Dominant Pedigree Previously Mapped to Chromosome 10q23-q24.
Benjamin R Lin, Derek J Le, Yabin Chen, Qiwei Wang, D Doug Chung, Christopher Croasdale

PLoS One· July 2017

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Identification of Potentially Pathogenic Variants in the Posterior Polymorphous Corneal Dystrophy 1 Locus.
Derek J Le, Duk-Won D Chung, Ricardo F Frausto, Michelle J Kim, Anthony J Aldave

PLoS One· July 2017

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Transcriptomic Analysis of Cultured Corneal Endothelial Cells as a Validation for Their Use in Cell Replacement Therapy.
Ricardo F Frausto, Derek J Le, Anthony J Aldave

Cell Transplant· March 2017

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Identification of novel PIKFYVE gene mutations associated with Fleck corneal dystrophy.
Jessica A Gee, Ricardo F Frausto, Duk-Won D Chung, Chulaluck Tangmonkongvoragul, Derek J Le

Mol Vis· June 2016

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Posterior amorphous corneal dystrophy is associated with a deletion of small leucine-rich proteoglycans on chromosome 12.
Michelle J Kim, Ricardo F Frausto, George O D Rosenwasser, Tina Bui, Derek J Le

PLoS One· January 2015

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