Publications by authors named "Derek Parks"

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Encoded library technology screening of hepatitis C virus NS4B yields a small-molecule compound series with in vitro replicon activity.
Christopher Arico-Muendel, Zhengrong Zhu, Hamilton Dickson, Derek Parks, Jesse Keicher

Antimicrob Agents Chemother· February 2016

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Preclinical Characterization and In Vivo Efficacy of GSK8853, a Small-Molecule Inhibitor of the Hepatitis C Virus NS4B Protein.
Jeffrey J Pouliot, Michael Thomson, Mi Xie, Joseph Horton, John Johnson, Derek Parks

Antimicrob Agents Chemother· October 2015

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Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists.
Terrence L Smalley, Sharon Boggs, Justin A Caravella, Lihong Chen, Katrina L Creech, Derek J Parks

Bioorg Med Chem Lett· January 2015

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Imidazo[1,2-a]pyridines That Directly Interact with Hepatitis C NS4B: Initial Preclinical Characterization.
J Brad Shotwell, Subramanian Baskaran, Pek Chong, Katrina L Creech, Renae M Crosby, Derek J Parks

ACS Med Chem Lett· July 2012

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Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene.
Adwoa Akwabi-Ameyaw, Justin A Caravella, Lihong Chen, Katrina L Creech, David N Deaton, Derek J Parks

Bioorg Med Chem Lett· October 2011

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Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene.
Jonathan Y Bass, Justin A Caravella, Lihong Chen, Katrina L Creech, David N Deaton, Derek J Parks

Bioorg Med Chem Lett· February 2011

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GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
Daniel Grant, Lei Yin, Jon L Collins, Derek J Parks, Lisa A Orband-Miller

ACS Chem Biol· October 2010

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Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.
Caroline A Phelan, Robert T Gampe, Millard H Lambert, Derek J Parks, Valerie Montana

Nat Struct Mol Biol· July 2010

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The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages.
Joseph P Marino, Lara S Kallander, Chun Ma, Hye-Ja Oh, Dennis Lee, Derek J Parks

Bioorg Med Chem Lett· October 2009

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FXR agonist activity of conformationally constrained analogs of GW 4064.
Adwoa Akwabi-Ameyaw, Jonathan Y Bass, Richard D Caldwell, Justin A Caravella, Lihong Chen, Derek J Parks

Bioorg Med Chem Lett· August 2009

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Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.
Jonathan Y Bass, Richard D Caldwell, Justin A Caravella, Lihong Chen, Katrina L Creech, Derek J Parks

Bioorg Med Chem Lett· June 2009

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Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.
David G Washburn, Tram H Hoang, Nino Campobasso, Angela Smallwood, Derek J Parks

Bioorg Med Chem Lett· February 2009

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Ligand modulation of REV-ERBalpha function resets the peripheral circadian clock in a phasic manner.
Qing Jun Meng, Andrew McMaster, Stephen Beesley, Wei Qun Lu, Julie Gibbs, Derek Parks

J Cell Sci· November 2008

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Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.
Esther Y Chao, Justin A Caravella, Mike A Watson, Nino Campobasso, Serena Ghisletti, Derek J Parks

J Med Chem· September 2008

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Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.
Adwoa Akwabi-Ameyaw, Jonathan Y Bass, Richard D Caldwell, Justin A Caravella, Lihong Chen, Derek J Parks

Bioorg Med Chem Lett· August 2008

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The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.
Hongwei Wang, Hao Li, Linda B Moore, Michael D L Johnson, Jodi M Maglich, Derek J Parks

Mol Endocrinol· April 2008

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Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways.
Lei Yin, Nan Wu, Joshua C Curtin, Mohammed Qatanani, Nava R Szwergold, Derek J Parks

Science· December 2007

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Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1.
Richard J Whitby, Sally Dixon, Patrick R Maloney, Philippe Delerive, Bryan J Goodwin, Derek J Parks

J Med Chem· November 2006

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Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives.
Roberto Pellicciari, Antimo Gioiello, Gabriele Costantino, Bahman M Sadeghpour, Giovanni Rizzo, Derek J Parks

J Med Chem· July 2006

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Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
Michael C Jaye, John A Krawiec, Nino Campobasso, Angela Smallwood, Chunyan Qiu, Derek J Parks

J Med Chem· August 2005

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Cell-free ligand binding assays for nuclear receptors.
Stacey A Jones, Derek J Parks, Steven A Kliewer

Methods Enzymol· December 2003

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X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.
Shawn Williams, Randy K Bledsoe, Jon L Collins, Sharon Boggs, Millard H Lambert, Derek Parks

J Biol Chem· July 2003

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Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.
Jodi M Maglich, Derek J Parks, Linda B Moore, Jon L Collins, Bryan Goodwin

J Biol Chem· May 2003

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6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.
Roberto Pellicciari, Stefano Fiorucci, Emidio Camaioni, Carlo Clerici, Gabriele Costantino, Derek J Parks

J Med Chem· August 2002

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Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.
Randy K Bledsoe, Valerie G Montana, Thomas B Stanley, Chris J Delves, Christopher J Apolito, Derek J Parks

Cell· July 2002

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