Publications by authors named "Bryan Goodwin"

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Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights From Comprehensive Multicenter Preclinical Studies.
Sarah-Eve Lemay, Mónica S Montesinos, Yann Grobs, Tetsuro Yokokawa, Tsukasa Shimauchi, Bryan Goodwin

Circulation· April 2025

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The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo.
Michael H J Rhodin, Archie C Reyes, Anand Balakrishnan, Nalini Bisht, Nicole M Kelly, Bryan Goodwin

Nat Commun· August 2024

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Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights from Comprehensive Multicenter Preclinical Studies.
Sarah-Eve Lemay, Monica S Montesinos, Yann Grobs, Tetsuro Yokokawa, Tsukasa Shimauchi, Bryan Goodwin

bioRxiv· June 2024

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Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
Kentaro Futatsugi, Shawn Cabral, Daniel W Kung, Kim Huard, Esther Lee, Bryan Goodwin

J Med Chem· November 2022

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EDP-305 in patients with NASH: A phase II double-blind placebo-controlled dose-ranging study.
Vlad Ratziu, Mary E Rinella, Brent A Neuschwander-Tetri, Eric Lawitz, Douglas Denham, Bryan Goodwin

J Hepatol· March 2022

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EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model.
Michael H J Rhodin, Nicole V McAllister, Jonathan Castillo, Sarah L Noton, Rachel Fearns, Bryan Goodwin

PLoS Pathog· March 2021

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Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis.
Neeta B Amin, Santos Carvajal-Gonzalez, Julie Purkal, Tong Zhu, Collin Crowley, Bryan Goodwin

Sci Transl Med· November 2019

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FGF21 increases water intake, urine output and blood pressure in rats.
Tod Turner, Xian Chen, Matthew Zahner, Alan Opsahl, George DeMarco, Bryan Goodwin

PLoS One· February 2019

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Concentration effects on biotic and abiotic processes in the removal of 1,1,2-trichloroethane and vinyl chloride using carbon-amended ZVI.
Bradley M Patterson, Matthew Lee, Trevor P Bastow, John T Wilson, Michael J Donn, Bryan Goodwin

J Contam Hydrol· May 2016

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A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects.
Saswata Talukdar, Yingjiang Zhou, Dongmei Li, Michelle Rossulek, Jennifer Dong, Bryan Goodwin

Cell Metab· March 2016

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Fibroblast growth factor 21 improves insulin sensitivity and synergizes with insulin in human adipose stem cell-derived (hASC) adipocytes.
Darwin V Lee, Dongmei Li, Qingyun Yan, Yimin Zhu, Bryan Goodwin

PLoS One· February 2016

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Characterization of a Novel Intestinal Glycerol-3-phosphate Acyltransferase Pathway and Its Role in Lipid Homeostasis.
Irani Khatun, Ronald W Clark, Nicholas B Vera, Kou Kou, Derek M Erion, Bryan Goodwin

J Biol Chem· February 2016

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FGF21 Regulates Sweet and Alcohol Preference.
Saswata Talukdar, Bryn M Owen, Parkyong Song, Genaro Hernandez, Yuan Zhang, Bryan Goodwin

Cell Metab· February 2016

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Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.
Kim Huard, Allyn T Londregan, Gregory Tesz, Kevin B Bahnck, Thomas V Magee, Bryan Goodwin

J Med Chem· September 2015

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Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).
Kentaro Futatsugi, Daniel W Kung, Suvi T M Orr, Shawn Cabral, David Hepworth, Bryan Goodwin

J Med Chem· September 2015

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Roles of Acyl-CoA:Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in Primary Hepatocytes.
Chen Li, Lena Li, Jihong Lian, Russell Watts, Randal Nelson, Bryan Goodwin

Arterioscler Thromb Vasc Biol· May 2015

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Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity.
Jingsong Cao, Sylvie Perez, Bryan Goodwin, Qingcong Lin, Haibing Peng

Am J Physiol Endocrinol Metab· May 2014

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Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver.
Angela M Hall, Kou Kou, Zhouji Chen, Terri A Pietka, Mrudula Kumar, Bryan Goodwin

J Lipid Res· May 2012

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Diabetes area participation analysis: a review of companies and targets described in the 2008 - 2010 patent literature.
Philip A Carpino, Bryan Goodwin

Expert Opin Ther Pat· December 2010

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Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.
Esther Y Chao, Justin A Caravella, Mike A Watson, Nino Campobasso, Serena Ghisletti, Bryan J Goodwin

J Med Chem· September 2008

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Recent advances in liver X receptor biology and chemistry.
Bryan J Goodwin, William J Zuercher, Jon L Collins

Curr Top Med Chem· July 2008

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Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.
Youn-Kyoung Lee, Daniel R Schmidt, Carolyn L Cummins, Mihwa Choi, Li Peng, Bryan Goodwin

Mol Endocrinol· June 2008

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The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.
Hongwei Wang, Hao Li, Linda B Moore, Michael D L Johnson, Jodi M Maglich, Bryan Goodwin

Mol Endocrinol· April 2008

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Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1.
Richard J Whitby, Sally Dixon, Patrick R Maloney, Philippe Delerive, Bryan J Goodwin

J Med Chem· November 2006

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Liver receptor homolog 1 is a negative regulator of the hepatic acute-phase response.
Nicolas Venteclef, Jason C Smith, Bryan Goodwin, Philippe Delerive

Mol Cell Biol· September 2006

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