Publications by authors named "Jennifer Dong"

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Assessing Clinical Integration of Point-of-Care Ultrasound With an Objective Structured Clinical Examination.
N Caroline Srisarajivakul-Klein, Jennifer Dong, Aron Mednick, Isaac Holmes, Lauren Comisar

J Med Educ Curric Dev· December 2025

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Microtracer-Based Assessment of the Mass Balance, Pharmacokinetics, and Excretion of [C]Berzosertib, an Intravenous ATR Inhibitor, in Patients With Advanced Solid Tumors: A Phase 1 Study.
Jayaprakasam Bolleddula, Holger Scheible, Florian Huber, Annick Seithel-Keuth, Hanno Schieferstein, Jennifer Dong

Clin Pharmacol Drug Dev· September 2025

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Effect of Cladribine Tablets on the Pharmacokinetics of a Combined Oral Contraceptive in Pre-Menopausal Women With Relapsing Multiple Sclerosis.
Robert Hermann, Kerstin Hellwig, Sumedh Gaikwad, Andrew Galazka, Afrim Bytyqi, Jennifer Q Dong

Clin Transl Sci· April 2025

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Asia-inclusive drug development leveraging principles of ICH E5 and E17 guidelines: Case studies illustrating quantitative clinical pharmacology as a foundational enabler.
Hong Lu, Lena Klopp-Schulze, Jatinder Kaur Mukker, Dandan Li, Yoshihiro Kuroki, Jennifer Dong

Clin Transl Sci· October 2024

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Asia-Inclusive Global Development of Enpatoran: Results of an Ethno-Bridging Study, Intrinsic/Extrinsic Factor Assessments and Disease Trajectory Modeling to Inform Design of a Phase II Multiregional Clinical Trial.
Lena Klopp-Schulze, Sathej Gopalakrishnan, Özkan Yalkinoglu, Yoshihiro Kuroki, Hong Lu, Jennifer Dong

Clin Pharmacol Ther· June 2024

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Immunogenicity of avelumab in patients with metastatic Merkel cell carcinoma or advanced urothelial carcinoma.
Ping Hu, Haiqing Isaac Dai, James Bourdage, Dongli Zhou, Ky Trang, Jennifer Dong

Clin Transl Sci· March 2024

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Implementation of whole-exome sequencing for pharmacogenomics profiling and exploring its potential clinical utilities.
Danyi Wang, Jayaprakasam Bolleddula, Anna Coenen-Stass, Thomas Grombacher, Jennifer Q Dong

Pharmacogenomics· March 2024

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Evobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective.
Holger Scheible, Hanno Schieferstein, Ralf Schmidt, Klaus Pusecker, Ulrike Gradhand, Jennifer Dong

Xenobiotica· December 2023

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Risk assessment of drug-drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach.
Yulia Vugmeyster, George Locke, Christoph Helwig, P Alexander Rolfe, Jennifer Q Dong

Clin Transl Sci· December 2022

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Alternatives to rifampicin: A review and perspectives on the choice of strong CYP3A inducers for clinical drug-drug interaction studies.
Jayaprakasam Bolleddula, Sathej Gopalakrishnan, Ping Hu, Jennifer Dong, Karthik Venkatakrishnan

Clin Transl Sci· September 2022

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Applying Modeling and Simulations for Rational Dose Selection of Novel Toll-Like Receptor 7/8 Inhibitor Enpatoran for Indications of High Medical Need.
Lena Klopp-Schulze, Jamie V Shaw, Jennifer Q Dong, Akash Khandelwal, Cristina Vazquez-Mateo

Clin Pharmacol Ther· August 2022

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Exposure-response analyses for the MET inhibitor tepotinib including patients in the pivotal VISION trial: support for dosage recommendations.
Wenyuan Xiong, Sofia Friberg Hietala, Joakim Nyberg, Orestis Papasouliotis, Andreas Johne, Jennifer Dong

Cancer Chemother Pharmacol· July 2022

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Phase 1b study of berzosertib and cisplatin in patients with advanced triple-negative breast cancer.
Melinda L Telli, Sara M Tolaney, Geoffrey I Shapiro, Mark Middleton, Simon R Lord, Jennifer Dong

NPJ Breast Cancer· April 2022

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A phase 1b study evaluating the safety and preliminary efficacy of berzosertib in combination with gemcitabine in patients with advanced non-small cell lung cancer.
Ruth Plummer, Emma Dean, Hendrik-Tobias Arkenau, Charles Redfern, Alexander I Spira, Jennifer Dong

Lung Cancer· January 2022

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Evobrutinib, a covalent Bruton's tyrosine kinase inhibitor: Mass balance, elimination route, and metabolism in healthy participants.
Holger Scheible, Martin Dyroff, Annick Seithel-Keuth, Eleanor Harrison-Moench, Nadra Mammasse, Jennifer Dong

Clin Transl Sci· November 2021

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Challenges in Drug Development Posed by the COVID-19 Pandemic: An Opportunity for Clinical Pharmacology.
Karthik Venkatakrishnan, Oezkan Yalkinoglu, Jennifer Q Dong, Lisa J Benincosa

Clin Pharmacol Ther· October 2020

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Once-weekly administration of a long-acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non-human primates.
Albert M Kim, Veena R Somayaji, Jennifer Q Dong, Timothy P Rolph, Yan Weng

Diabetes Obes Metab· December 2017

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Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome.
Jennifer Q Dong, James R Gosset, Odette A Fahmi, Zhiwu Lin, Jeffrey R Chabot

Drug Metab Dispos· May 2017

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Standardized Mixed-Meal Tolerance and Arginine Stimulation Tests Provide Reproducible and Complementary Measures of β-Cell Function: Results From the Foundation for the National Institutes of Health Biomarkers Consortium Investigative Series.
Sudha S Shankar, Adrian Vella, Ralph H Raymond, Myrlene A Staten, Roberto A Calle, Jennifer Q Dong

Diabetes Care· September 2016

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A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects.
Saswata Talukdar, Yingjiang Zhou, Dongmei Li, Michelle Rossulek, Jennifer Dong

Cell Metab· March 2016

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Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans.
Jennifer Q Dong, Manthena V Varma, Angela Wolford, Tim Ryder, Li Di

Drug Metab Dispos· February 2016

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Pharmacokinetics and pharmacodynamics of PF-05231023, a novel long-acting FGF21 mimetic, in a first-in-human study.
Jennifer Q Dong, Michelle Rossulek, Veena R Somayaji, Daniel Baltrukonis, Yali Liang

Br J Clin Pharmacol· November 2015

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Mesodermal Fgf10b cooperates with other fibroblast growth factors during induction of otic and epibranchial placodes in zebrafish.
Kirstin Maulding, Mahesh S Padanad, Jennifer Dong, Bruce B Riley

Dev Dyn· October 2014

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Preparation of megabase-sized DNA from a variety of organisms using the nuclei method for advanced genomics research.
Meiping Zhang, Yang Zhang, Chantel F Scheuring, Cheng-Cang Wu, Jennifer J Dong

Nat Protoc· February 2012

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Construction of BIBAC and BAC libraries from a variety of organisms for advanced genomics research.
Hong-Bin Zhang, Chantel F Scheuring, Meiping Zhang, Yang Zhang, Cheng-Cang Wu, Jennifer J Dong

Nat Protoc· February 2012

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