Publications by authors named "George Locke"

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Next-generation Drosophila protein interactome map and its functional implications.
Guruharsha Bhat, Kejie Li, George Locke, Marina Theodorou, Krishna Kilambi

Dev Cell· September 2024

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Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Patients With Non-Small Cell Lung Cancer Resistant or Refractory to Immune Checkpoint Inhibitors.
Fabrice Barlesi, Nicolas Isambert, Enriqueta Felip, Byoung Chul Cho, Dae Ho Lee, George Locke

Oncologist· March 2023

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Risk assessment of drug-drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach.
Yulia Vugmeyster, George Locke, Christoph Helwig, P Alexander Rolfe, Jennifer Q Dong

Clin Transl Sci· December 2022

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Identification of as a predictive biomarker of response to bintrafusp alfa in a phase 1 trial in patients with advanced triple-negative breast cancer.
Alexander Spira, Ahmad Awada, Nicolas Isambert, David Lorente, Nicolas Penel, George Locke

Front Oncol· December 2022

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Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses.
Yan Lan, Tsz-Lun Yeung, Hui Huang, Ansgar A Wegener, Somdutta Saha, George Locke

J Immunother Cancer· July 2022

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Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion.
Yan Lan, Mahmoud Moustafa, Maximilian Knoll, Chunxiao Xu, Jennifer Furkel, George Locke

Cancer Cell· October 2021

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Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β.
Yan Lan, Dong Zhang, Chunxiao Xu, Kenneth W Hance, Bo Marelli, George Locke

Sci Transl Med· January 2018

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Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor-Related Protein 6.
Bryce G Johnson, Shuyu Ren, Gamze Karaca, Ivan G Gomez, Cécile Fligny, George Locke

J Am Soc Nephrol· June 2017

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A Biophysical Approach to Predicting Protein-DNA Binding Energetics.
George Locke, Alexandre V Morozov

Genetics· August 2015

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Global remodeling of nucleosome positions in C. elegans.
George Locke, Devorah Haberman, Steven M Johnson, Alexandre V Morozov

BMC Genomics· April 2013

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Statistical mechanics of nucleosome ordering by chromatin-structure-induced two-body interactions.
Răzvan V Chereji, Denis Tolkunov, George Locke, Alexandre V Morozov

Phys Rev E Stat Nonlin Soft Matter Phys· May 2011

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High-throughput sequencing reveals a simple model of nucleosome energetics.
George Locke, Denis Tolkunov, Zarmik Moqtaderi, Kevin Struhl, Alexandre V Morozov

Proc Natl Acad Sci U S A· December 2010

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Characteristics of ventricular shunt malfunctions among patients with neurocysticercosis.
Rosemarie Kelley, Duc H Duong, George E Locke

Neurosurgery· April 2002

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