Publications by authors named "Derrick Witcher"

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Impact of antibody Fc engineering on translational pharmacology, and safety: insights from industry case studies.
Frank R Brennan, J Ryan Polli, Jean Sathish, Melissa Ramones, Babette Wolf, Derrick Witcher

MAbs· December 2025

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Ucenprubart is an agonistic antibody to CD200R with the potential to treat inflammatory skin disease: preclinical development and a phase 1 clinical study.
Anja Koester, Derrick R Witcher, Mark Lee, Stephen J Demarest, Scott Potter

Nat Commun· May 2025

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The Therapeutic Monoclonal Antibody Bamlanivimab Does Not Enhance SARS-CoV-2 Infection by FcR-Mediated Mechanisms.
Robert W Cross, Christopher M Wiethoff, Patricia Brown-Augsburger, Shawn Berens, Jamie Blackbourne, Derrick R Witcher

Pathogens· November 2023

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A nondepleting anti-CD19 antibody impairs B cell function and inhibits autoimmune diseases.
Jeffrey S Boyles, Dorota Sadowski, Scott Potter, Aleksandra Vukojicic, James Parker, Derrick R Witcher

JCI Insight· July 2023

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Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody.
Jeffrey S Boyles, Catherine B Beidler, Beth A Strifler, Daniel S Girard, Zhanna Druzina, Derrick R Witcher

MAbs· September 2021

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Validation of a de-immunization strategy for monoclonal antibodies using cynomolgus macaque as a surrogate for human.
Natalia Kovalova, Jeffrey Boyles, Yi Wen, Derrick R Witcher, Patricia L Brown-Augsburger

Biopharm Drug Dispos· March 2020

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Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies.
Amita Datta-Mannan, Selina Estwick, Chen Zhou, Hiuwan Choi, Nicole E Douglass, Derrick R Witcher

MAbs· January 2020

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Targeting the hepcidin-ferroportin pathway in anaemia of chronic kidney disease.
Matthew Sheetz, Philip Barrington, Sophie Callies, Paul H Berg, Juliet McColm, Derrick R Witcher

Br J Clin Pharmacol· May 2019

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Engineered FcRn Binding Fusion Peptides Significantly Enhance the Half-Life of a Fab Domain in Cynomolgus Monkeys.
Amita Datta-Mannan, Jeffrey Boyles, Lihua Huang, Zhaoyan Y Jin, Amber Peariso, Derrick R Witcher

Biotechnol J· March 2019

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FcγRIIIa-dependent IFN-γ release in whole blood assay is predictive of therapeutic IgG1 antibodies safety.
Nada S Alakhras, Jiabin Qiu, Guilherme V Rocha, Derrick R Witcher, Anja Koester

MAbs· February 2019

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Modulation of IgG1 immunoeffector function by glycoengineering of the GDP-fucose biosynthesis pathway.
Ronan M Kelly, Ronald L Kowle, Zhirui Lian, Beth A Strifler, Derrick R Witcher

Biotechnol Bioeng· March 2018

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Role of TGF-alpha in the progression of diabetic kidney disease.
Josef G Heuer, Shannon M Harlan, Derek D Yang, Dianna L Jaqua, Jeffrey S Boyles, Derrick R Witcher

Am J Physiol Renal Physiol· June 2017

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Structural basis of selectivity and neutralizing activity of a TGFα/epiregulin specific antibody.
Jeffrey S Boyles, Shane Atwell, Zhanna Druzina, Josef G Heuer, Derrick R Witcher

Protein Sci· November 2016

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The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies.
Amita Datta-Mannan, Jirong Lu, Derrick R Witcher, Donmienne Leung, Ying Tang

MAbs· August 2016

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Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics.
Amita Datta-Mannan, Arunkumar Thangaraju, Donmienne Leung, Ying Tang, Derrick R Witcher

MAbs· March 2016

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Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys.
Amita Datta-Mannan, Derrick R Witcher, Jirong Lu, Victor J Wroblewski

MAbs· February 2015

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Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB.
Thomas Sonnweber, David Nachbaur, Andrea Schroll, Manfred Nairz, Markus Seifert, Derrick R Witcher

Gut· December 2014

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Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats.
Milan Theurl, Manfred Nairz, Andrea Schroll, Thomas Sonnweber, Malte Asshoff, Derrick R Witcher

Haematologica· September 2014

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Generation and characterization of tabalumab, a human monoclonal antibody that neutralizes both soluble and membrane-bound B-cell activating factor.
Joseph Manetta, Holly Bina, Paul Ryan, Niles Fox, Derrick R Witcher

J Inflamm Res· September 2014

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Generation and activity of a humanized monoclonal antibody that selectively neutralizes the epidermal growth factor receptor ligands transforming growth factor-α and epiregulin.
Catherine B Beidler, Ramona J Petrovan, Elaine M Conner, Jeffrey S Boyles, Derek D Yang, Derrick R Witcher

J Pharmacol Exp Ther· May 2014

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High-fat diet causes iron deficiency via hepcidin-independent reduction of duodenal iron absorption.
Thomas Sonnweber, Claudia Ress, Manfred Nairz, Igor Theurl, Andrea Schroll, Derrick R Witcher

J Nutr Biochem· December 2012

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A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia.
Helen M Marriott, Marc Daigneault, Alfred A R Thompson, Sarah R Walmsley, Sharonjit K Gill, Derrick R Witcher

Thorax· November 2012

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FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys.
Amita Datta-Mannan, Chi-Kin Chow, Craig Dickinson, David Driver, Jirong Lu, Derrick R Witcher

Drug Metab Dispos· August 2012

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Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.
Irene Pichler, Cosetta Minelli, Serena Sanna, Toshiko Tanaka, Christine Schwienbacher, Derrick R Witcher

Hum Mol Genet· March 2011

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A dual-monoclonal sandwich ELISA specific for hepcidin-25.
Anthony M Butterfield, Peng Luan, Derrick R Witcher, Joseph Manetta, Anthony T Murphy

Clin Chem· November 2010

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