Publications by authors named "Devin Leake"

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Improved PCR Amplification of Broad Spectrum GC DNA Templates.
Nicholas Guido, Elena Starostina, Devin Leake, Ishtiaq Saaem

PLoS One· July 2017

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Determination of a Screening Metric for High Diversity DNA Libraries.
Nicholas J Guido, Steven Handerson, Elaine M Joseph, Devin Leake, Li A Kung

PLoS One· July 2017

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Next-Gen Gene Synthesis Enables Large-Scale Engineering in Biological Systems: Recent advances in synthetic biology are making this field more promising than ever.
Devin Leake

IEEE Pulse· July 2016

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RNAi Screening with Self-Delivering, Synthetic siRNAs for Identification of Genes That Regulate Primary Human T Cell Migration.
Michael Freeley, Emily Derrick, Eugene Dempsey, Antje Hoff, Anthony Davies, Devin Leake

J Biomol Screen· September 2015

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Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB-siRNA conjugates.
Trinna L Cuellar, Dwight Barnes, Christopher Nelson, Joshua Tanguay, Shang-Fan Yu, Devin Leake

Nucleic Acids Res· January 2015

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Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs.
Daniel Mutisya, Chelliah Selvam, Benjamin D Lunstad, Pradeep S Pallan, Amanda Haas, Devin Leake

Nucleic Acids Res· June 2014

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Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages.
Paul Tanui, Scott D Kennedy, Benjamin D Lunstad, Amanda Haas, Devin Leake

Org Biomol Chem· February 2014

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Gene Silencing in Skin After Deposition of Self-Delivery siRNA With a Motorized Microneedle Array Device.
Robyn P Hickerson, Winston C Wey, David L Rimm, Tycho Speaker, Susie Suh, Devin Leake

Mol Ther Nucleic Acids· October 2013

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Optimized PCR conditions and increased shRNA fold representation improve reproducibility of pooled shRNA screens.
Žaklina Strezoska, Abel Licon, Josh Haimes, Katie Jansen Spayd, Kruti M Patel, Devin Leake

PLoS One· February 2013

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Inhibition of CD44 gene expression in human skin models, using self-delivery short interfering RNA administered by dissolvable microneedle arrays.
Maria Fernanda Lara, Emilio González-González, Tycho J Speaker, Robyn P Hickerson, Devin Leake

Hum Gene Ther· August 2012

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Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens.
Victoria A Meliopoulos, Lauren E Andersen, Katherine F Birrer, Kaylene J Simpson, John W Lowenthal, Devin Leake

FASEB J· April 2012

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In vivo sustained release of siRNA from solid lipid nanoparticles.
Tatsiana Lobovkina, Gunilla B Jacobson, Emilio Gonzalez-Gonzalez, Robyn P Hickerson, Devin Leake

ACS Nano· December 2011

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Development of quantitative molecular clinical end points for siRNA clinical trials.
Robyn P Hickerson, Sancy A Leachman, Lana N Pho, Emilio Gonzalez-Gonzalez, Frances J D Smith, Devin Leake

J Invest Dermatol· May 2011

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In vivo imaging of human and mouse skin with a handheld dual-axis confocal fluorescence microscope.
Hyejun Ra, Wibool Piyawattanametha, Emilio Gonzalez-Gonzalez, Michael J Mandella, Gordon S Kino, Devin Leake

J Invest Dermatol· May 2011

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Use of self-delivery siRNAs to inhibit gene expression in an organotypic pachyonychia congenita model.
Robyn P Hickerson, Manuel A Flores, Devin Leake, Maria F Lara, Christopher H Contag

J Invest Dermatol· May 2011

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Biodegradable nanoparticles with sustained release of functional siRNA in skin.
Gunilla B Jacobson, Emilio Gonzalez-Gonzalez, Ryan Spitler, Rajesh Shinde, Devin Leake

J Pharm Sci· October 2010

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Silencing of reporter gene expression in skin using siRNAs and expression of plasmid DNA delivered by a soluble protrusion array device (PAD).
Emilio Gonzalez-Gonzalez, Tycho J Speaker, Robyn P Hickerson, Ryan Spitler, Manuel A Flores, Devin Leake

Mol Ther· September 2010

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Specificity and functionality of microRNA inhibitors.
Barbara Robertson, Andrew B Dalby, Jon Karpilow, Anastasia Khvorova, Devin Leake

Silence· April 2010

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Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients.
Robyn P Hickerson, Devin Leake, Lana N Pho, Sancy A Leachman, Roger L Kaspar

J Dermatol Sci· November 2009

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First siRNA library screening in hard-to-transfect HUVEC cells.
Markus Zumbansen, Ludger M Altrogge, Nicole Ue Spottke, Sonja Spicker, Sheila M Offizier, Devin Leake

J RNAi Gene Silencing· October 2009

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Functional profiling reveals critical role for miRNA in differentiation of human mesenchymal stem cells.
Angela Schoolmeesters, Teresa Eklund, Devin Leake, Annaleen Vermeulen, Queta Smith

PLoS One· August 2009

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KLF6-SV1 is a novel antiapoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model.
Analisa Difeo, Fei Huang, Jaya Sangodkar, Esteban A Terzo, Devin Leake

Cancer Res· June 2009

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Stability study of unmodified siRNA and relevance to clinical use.
Robyn P Hickerson, Alexander V Vlassov, Qian Wang, Devin Leake, Heini Ilves

Oligonucleotides· December 2008

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Identification of genes that regulate epithelial cell migration using an siRNA screening approach.
Kaylene J Simpson, Laura M Selfors, James Bui, Angela Reynolds, Devin Leake

Nat Cell Biol· September 2008

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KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.
Goutham Narla, Analisa DiFeo, Yolanda Fernandez, Saravana Dhanasekaran, Fei Huang, Devin Leake

J Clin Invest· August 2008

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