Publications by authors named "Devon Sheppard"

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The conserved Spd-2/CEP192 domain adopts a unique protein fold to promote centrosome scaffold assembly.
Liuyi Hu, Alan Wainman, Antonina Andreeva, Muladili Apizi, Ines Alvarez-Rodrigo, Devon Sheppard

Sci Adv· March 2025

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Structural and functional studies of the EGF20-27 region reveal new features of the human Notch receptor important for optimal activation.
Zhihan Bo, Thomas Rowntree, Steven Johnson, Hilman Nurmahdi, Richard J Suckling, Devon Sheppard

Structure· December 2024

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SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
Mohammad Hamdy Abdelrazak Morsy, Ingrid Lilienthal, Martin Lord, Magali Merrien, Agata Magdalena Wasik, Devon Sheppard

Blood· May 2024

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Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis.
Oliver J Acton, Devon Sheppard, Simone Kunzelmann, Sarah J Caswell, Andrea Nans

Nat Commun· May 2024

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Characterization of a glycan-binding complex of minor pilins completes the analysis of type 4 pili subunits.
Meriam Shahin, Devon Sheppard, Claire Raynaud, Jamie-Lee Berry, Ishwori Gurung

Proc Natl Acad Sci U S A· January 2023

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PilB from is a bimodular type IV pilin with a direct role in adhesion.
Claire Raynaud, Devon Sheppard, Jamie-Lee Berry, Ishwori Gurung, Vladimir Pelicic

Proc Natl Acad Sci U S A· June 2021

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The major subunit of widespread competence pili exhibits a novel and conserved type IV pilin fold.
Devon Sheppard, Jamie-Lee Berry, Rémi Denise, Eduardo P C Rocha, Steve Matthews

J Biol Chem· May 2020

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Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy.
Massimo Masiero, Demin Li, Pat Whiteman, Carol Bentley, Jenny Greig, Devon Sheppard

Mol Cancer Ther· November 2019

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Structural basis for therapeutic inhibition of complement C5.
Matthijs M Jore, Steven Johnson, Devon Sheppard, Natalie M Barber, Yang I Li

Nat Struct Mol Biol· May 2016

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Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.
Philip C Weisshuhn, Devon Sheppard, Paul Taylor, Pat Whiteman, Susan M Lea

Structure· April 2016

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Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands.
Paul Taylor, Hideyuki Takeuchi, Devon Sheppard, Chandramouli Chillakuri, Susan M Lea

Proc Natl Acad Sci U S A· May 2014

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Structural analysis uncovers lipid-binding properties of Notch ligands.
Chandramouli R Chillakuri, Devon Sheppard, Ma Xenia G Ilagan, Laurie R Holt, Felicity Abbott

Cell Rep· November 2013

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The CD46-Jagged1 interaction is critical for human TH1 immunity.
Gaëlle Le Friec, Devon Sheppard, Pat Whiteman, Christian M Karsten, Salley Al-Tilib Shamoun

Nat Immunol· December 2012

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Notch receptor-ligand binding and activation: insights from molecular studies.
Chandramouli R Chillakuri, Devon Sheppard, Susan M Lea, Penny A Handford

Semin Cell Dev Biol· June 2012

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Variation in quadrupole couplings of alpha deuterons in ubiquitin suggests the presence of C(alpha)-H(alpha)...O=C hydrogen bonds.
Devon Sheppard, Da-Wei Li, Raquel Godoy-Ruiz, Rafael Brüschweiler, Vitali Tugarinov

J Am Chem Soc· June 2010

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Estimating quadrupole couplings of amide deuterons in proteins from direct measurements of 2H spin relaxation rates.
Devon Sheppard, Vitali Tugarinov

J Magn Reson· April 2010

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Experimental approaches for NMR studies of side-chain dynamics in high-molecular-weight proteins.
Devon Sheppard, Remco Sprangers, Vitali Tugarinov

Prog Nucl Magn Reson Spectrosc· January 2010

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Deuterium spin probes of backbone order in proteins: 2H NMR relaxation study of deuterated carbon alpha sites.
Devon Sheppard, Da-Wei Li, Rafael Brüschweiler, Vitali Tugarinov

J Am Chem Soc· November 2009

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Methyl-detected 'out-and-back' NMR experiments for simultaneous assignments of Alabeta and Ilegamma2 methyl groups in large proteins.
Devon Sheppard, Chenyun Guo, Vitali Tugarinov

J Biomol NMR· April 2009

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4D 1H-13C NMR spectroscopy for assignments of alanine methyls in large and complex protein structures.
Devon Sheppard, Chenyun Guo, Vitali Tugarinov

J Am Chem Soc· February 2009

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Intracellular IL-1 receptor antagonist type 1 inhibits IL-1-induced cytokine production in keratinocytes through binding to the third component of the COP9 signalosome.
Nirmal K Banda, Carla Guthridge, Devon Sheppard, Kelly S Cairns, Michele Muggli

J Immunol· March 2005

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Antarctic Dry Valley mineral soils contain unexpectedly high levels of microbial biomass.
Don A Cowan, Nick J Russell, Adam Mamais, Devon M Sheppard

Extremophiles· October 2002

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