Publications by authors named "Dharam Paul"

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The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease.
Paul Rolan, Elizabeth Doolin, Dharam Paul, Julia Crossman, Michael Odontiadis

Clin Pharmacol Drug Dev· September 2025

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Identification of QTLs associated with modifiers influencing kernel opacity, kernel hardness, and tryptophan content in quality protein maize.
Diksha Jasrotia, Sushil Kumar, Yashmeet Kaur, Abhijit Kumar Das, Alla Singh, Dharam Paul

Front Plant Sci· May 2025

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A phase 2, placebo-controlled study to evaluate the efficacy and safety of BNC210, an alpha-7 nicotinic receptor negative allosteric modulator, for acute, as-needed treatment of social anxiety disorder (SAD) - The PREVAIL study.
Spyros Papapetropoulos, Elizabeth Doolin, Michael Odontiadis, Dharam Paul, Mark Jaros, Paul Rolan

Psychiatry Res· April 2025

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BNC210, an α7 Nicotinic Receptor Modulator, in Post-Traumatic Stress Disorder.
Spyridon Papapetropoulos, Elizabeth Doolin, Susan O'Connor, Dharam Paul, Michael Odontiadis, Paul Rolan

NEJM Evid· January 2025

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BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents.
Susan M O'Connor, Brad E Sleebs, Ian P Street, Bernard L Flynn, Jonathan B Baell, Dharam Paul

Neuropharmacology· March 2024

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Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs.
Andrew J Harvey, Thomas D Avery, Laurent Schaeffer, Christophe Joseph, Belinda C Huff, Dharam Paul

ACS Med Chem Lett· May 2019

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Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
Bernard L Flynn, Gurmit S Gill, Damian W Grobelny, Jason H Chaplin, Dharam Paul

J Med Chem· September 2011

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Cytochrome c-binding "proteo-dendrimers" as new types of apoptosis inhibitors working in HeLa cell systems.
Hideki Azuma, Yuuka Yoshida, Dharam Paul, Satoshi Shinoda, Hiroshi Tsukube

Org Biomol Chem· April 2009

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Experimental and theoretical approaches toward anion-responsive tripod-lanthanide complexes: mixed-donor ligand effects on lanthanide complexation and luminescence sensing profiles.
Yumiko Kataoka, Dharam Paul, Hiroyuki Miyake, Tsuyoshi Yaita, Eisaku Miyoshi

Chemistry· September 2008

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Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3.
Julia Cianci, Jonathan B Baell, Bernard L Flynn, Robert W Gable, Jorgen A Mould, Dharam Paul

Bioorg Med Chem Lett· March 2008

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A Cl- anion-responsive luminescent Eu3+ complex with a chiral tripod: ligand substituent effects on ternary complex stoichiometry and anion sensing selectivity.
Yumiko Kataoka, Dharam Paul, Hiroyuki Miyake, Satoshi Shinoda, Hiroshi Tsukube

Dalton Trans· July 2007

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Dendrimer container for anion-responsive lanthanide complexation and "on-off" switchable near-infrared luminescence.
Hiroshi Tsukube, Yukiko Suzuki, Dharam Paul, Yumiko Kataoka, Satoshi Shinoda

Chem Commun (Camb)· June 2007

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Proteo-dendrimers designed for complementary recognition of cytochrome c: dendrimer architecture toward nanoscale protein complexation.
Dharam Paul, Hiroyuki Miyake, Satoshi Shinoda, Hiroshi Tsukube

Chemistry· February 2006

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Photodynamics of excitation energy transfer in self-assembled dyads. Evidence for back transfer.
Isabelle Leray, Bernard Valeur, Dharam Paul, Emilie Regnier, Matthieu Koepf

Photochem Photobiol Sci· March 2005

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Cytochrome c-crown ether complexes as supramolecular catalysts: cold-active synzymes for asymmetric sulfoxide oxidation in methanol.
Atsuko Suzumura, Dharam Paul, Hideki Sugimoto, Satoshi Shinoda, Ryan R Julian

Inorg Chem· February 2005

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Chemical activation of cytochrome c proteins via crown ether complexation: cold-active synzymes for enantiomer-selective sulfoxide oxidation in methanol.
Dharam Paul, Atsuko Suzumura, Hideki Sugimoto, Junji Teraoka, Satoshi Shinoda

J Am Chem Soc· September 2003

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Induced fit process in the selective distal binding of imidazoles in zinc(II) porphyrin receptors.
Dharam Paul, Frédéric Melin, Caroline Hirtz, Jennifer Wytko, Philippe Ochsenbein

Inorg Chem· June 2003

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Design and synthesis of a self-assembled photochemical dyad based on selective imidazole recognition.
Dharam Paul, Jennifer A Wytko, Matthieu Koepf, Jean Weiss

Inorg Chem· July 2002

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