Publications by authors named "Jason H Chaplin"

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A new era for chagas disease drug discovery?
Martine Keenan, Jason H Chaplin

Prog Med Chem· April 2015

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Convergent access to polycyclic cyclopentanoids from α,β-unsaturated acid chlorides and alkynes through a reductive coupling, nazarov cyclization sequence.
Jason H Chaplin, Kristal Jackson, Jonathan M White, Bernard L Flynn

J Org Chem· April 2014

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Two analogues of fenarimol show curative activity in an experimental model of Chagas disease.
Martine Keenan, Jason H Chaplin, Paul W Alexander, Michael J Abbott, Wayne M Best

J Med Chem· December 2013

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Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.
Tatiana Y Hargrove, Zdzislaw Wawrzak, Paul W Alexander, Jason H Chaplin, Martine Keenan

J Biol Chem· November 2013

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Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi.
Martine Keenan, Paul W Alexander, Jason H Chaplin, Michael J Abbott, Hugo Diao

Future Med Chem· October 2013

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Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas disease.
Martine Keenan, Michael J Abbott, Paul W Alexander, Tanya Armstrong, Wayne M Best, Jason H Chaplin

J Med Chem· May 2012

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Oxazolidinone-promoted, torquoselective Nazarov cyclizations.
Daniel J Kerr, Michael Miletic, Jason H Chaplin, Jonathan M White, Bernard L Flynn

Org Lett· April 2012

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Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
Bernard L Flynn, Gurmit S Gill, Damian W Grobelny, Jason H Chaplin, Dharam Paul

J Med Chem· September 2011

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An efficient synthesis and substitution of 3-aroyl-2-bromobenzo[b]furans.
Gurmit S Gill, Damian W Grobelny, Jason H Chaplin, Bernard L Flynn

J Org Chem· February 2008

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An enantioselective double Diels-Alder approach to the tetracyclic framework of colombiasin A.
Jason H Chaplin, Alison J Edwards, Bernard L Flynn

Org Biomol Chem· June 2003

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