Publications by authors named "Dimitri Topalis"

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A Herpes Simplex Virus 1 DNA Polymerase Multidrug Resistance Mutation Identified in a Patient With Immunodeficiency and Confirmed by Gene Editing.
Hanna Helena Schalkwijk, Aspasia Georgala, Sarah Gillemot, Arturo Temblador, Dimitri Topalis

J Infect Dis· November 2023

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Thymidine kinase and protein kinase in drug-resistant herpesviruses: Heads of a Lernaean Hydra.
Dimitri Topalis, Sarah Gillemot, Robert Snoeck, Graciela Andrei

Drug Resist Updat· March 2018

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Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1.
Dimitri Topalis, Tatiane C Nogueira, Tim De Schutter, Chahrazade El Amri, Marcela Krečmerová

Oncotarget· March 2016

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Tenofovir Activating Kinases May Impact the Outcome of HIV Treatment and Prevention.
Dimitri Topalis, Robert Snoeck, Graciela Andrei

EBioMedicine· September 2015

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ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping.
Sophie Duraffour, María M Lorenzo, Gudrun Zöller, Dimitri Topalis, Doug Grosenbach

J Antimicrob Chemother· May 2015

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Spectrum of activity and mechanisms of resistance of various nucleoside derivatives against gammaherpesviruses.
Natacha Coen, Sophie Duraffour, Dimitri Topalis, Robert Snoeck, Graciela Andrei

Antimicrob Agents Chemother· December 2014

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KAY-2-41, a novel nucleoside analogue inhibitor of orthopoxviruses in vitro and in vivo.
Sophie Duraffour, Robert Drillien, Kazuhiro Haraguchi, Jan Balzarini, Dimitri Topalis

Antimicrob Agents Chemother· September 2014

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Reduced tumorigenicity and pathogenicity of cervical carcinoma SiHa cells selected for resistance to cidofovir.
Tim De Schutter, Graciela Andrei, Dimitri Topalis, Sophie Duraffour, Tania Mitera

Mol Cancer· December 2013

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Cidofovir selectivity is based on the different response of normal and cancer cells to DNA damage.
Tim De Schutter, Graciela Andrei, Dimitri Topalis, Lieve Naesens, Robert Snoeck

BMC Med Genomics· May 2013

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Heterogeneity and evolution of thymidine kinase and DNA polymerase mutants of herpes simplex virus type 1: implications for antiviral therapy.
Graciela Andrei, Aspasia Georgala, Dimitri Topalis, Pierre Fiten, Michel Aoun

J Infect Dis· April 2013

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Cidofovir treatment improves the pathology caused by the growth of human papillomavirus-positive cervical carcinoma xenografts in athymic nude mice.
Tim De Schutter, Graciela Andrei, Dimitri Topalis, Sophie Duraffour, Tania Mitera

Cancer Lett· February 2013

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Mutations conferring resistance to viral DNA polymerase inhibitors in camelpox virus give different drug-susceptibility profiles in vaccinia virus.
Sophie Duraffour, Graciela Andrei, Dimitri Topalis, Marcela Krečmerová, Jean-Marc Crance

J Virol· July 2012

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Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.
Dimitri Topalis, Ugo Pradère, Vincent Roy, Christophe Caillat, Ahmed Azzouzi

J Med Chem· January 2011

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Structural basis for the specificity of thymidylate kinases from human pathogens: implications for nucleotide analogues activation.
Philippe Meyer, Christophe Caillat, Dimitri Topalis, Jan Balzarini, Dominique Deville-Bonne

Nucleic Acids Symp Ser (Oxf)· May 2010

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Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase.
Constance Auvynet, Dimitri Topalis, Christophe Caillat, Hélène Munier-Lehmann, Edward Seclaman

Biochem Biophys Res Commun· October 2009

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Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy.
Christophe Caillat, Dimitri Topalis, Luigi A Agrofoglio, Sylvie Pochet, Jan Balzarini

Proc Natl Acad Sci U S A· November 2008

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Mechanisms of substrate selectivity for Bacillus anthracis thymidylate kinase.
Cecilia Carnrot, Liya Wang, Dimitri Topalis, Staffan Eriksson

Protein Sci· September 2008

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Looking for new pyrimidine acyclic nucleotide analogues designed for phosphorylation by human UMP-CMP kinase.
Dimitri Topalis, Hiroki Kumamoto, Julie A C Alexandre, Laurence Dugué, Sylvie Pochet

Nucleosides Nucleotides Nucleic Acids· March 2008

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Alkyne-azide click chemistry mediated carbanucleosides synthesis.
Julie Broggi, Nicolas Joubert, Vincent Aucagne, Sabine Berteina-Raboin, S Diez-Gonzalez, Dimitri Topalis

Nucleosides Nucleotides Nucleic Acids· March 2008

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Cross-metathesis mediated synthesis of new acyclic nucleoside phosphonates.
Vincent Roy, Hiroki Kumamoto, Sabine Berteina-Raboin, Steven P Nolan, Dimitri Topalis

Nucleosides Nucleotides Nucleic Acids· March 2008

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Enantioselectivity of human AMP, dTMP and UMP-CMP kinases.
Julie A C Alexandre, Béatrice Roy, Dimitri Topalis, Sylvie Pochet, Christian Périgaud

Nucleic Acids Res· September 2007

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Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site.
Dimitri Topalis, Hiroki Kumamoto, Maria-Fernanda Amaya Velasco, Laurence Dugué, Ahmed Haouz

FEBS J· July 2007

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Substrate specificity of vaccinia virus thymidylate kinase.
Dimitri Topalis, Bruno Collinet, Cécile Gasse, Laurence Dugué, Jan Balzarini

FEBS J· December 2005

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