Publications by authors named "Nicolas Joubert"

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Anti-cathepsin D antibody-drug conjugates for the targeted delivery of monomethyl auristatin F and E elicit potent anticancer activity in breast cancer.
Diane Nishimwe, Gaëlle Guillon, Aude Mallavialle, Camille Martin, Steve Huvelle, Nicolas Joubert

Biomed Pharmacother· December 2025

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Development of Optimized Exatecan-Based Immunoconjugates with Potent Antitumor Efficacy in HER2-Positive Breast Cancer.
Etienne Auvert, Emmanuel Douez, Louis Jolivet, Tiffany Witkowski, Anne-Catherine Jallas, Nicolas Joubert

J Med Chem· September 2025

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Branched pegylated linker-auristatin to control hydrophobicity for the production of homogeneous minibody-drug conjugate against HER2-positive breast cancer.
Emmanuel Douez, Emilie Allard-Vannier, Imène Ait Mohamed Amar, Louis Jolivet, Fanny Boursin, Nicolas Joubert

J Control Release· February 2024

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Improving the response to oxaliplatin by targeting chemotherapy-induced CLDN1 in resistant metastatic colorectal cancer cells.
Sara Cherradi, Véronique Garambois, Johanna Marines, Augusto Faria Andrade, Alexandra Fauvre, Nicolas Joubert

Cell Biosci· April 2023

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Intra-Domain Cysteines (IDC), a New Strategy for the Development of Original Antibody Fragment-Drug Conjugates (FDCs).
Louis Jolivet, Imène Ait Mohamed Amar, Catherine Horiot, Fanny Boursin, Cyril Colas, Nicolas Joubert

Pharmaceutics· July 2022

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Therapeutic antibodies - natural and pathological barriers and strategies to overcome them.
Yara Al Ojaimi, Timothée Blin, Juliette Lamamy, Matthieu Gracia, Aubin Pitiot, Nicolas Joubert

Pharmacol Ther· May 2022

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Dual intra- and extracellular release of monomethyl auristatin E from a neutrophil elastase-sensitive antibody-drug conjugate.
Imene Ait Mohamed Amar, Steve Huvelle, Emmanuel Douez, Stéphanie Letast, Sylvain Henrion, Nicolas Joubert

Eur J Med Chem· February 2022

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Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor.
Francesco De Pascali, Mohammed Akli Ayoub, Riccardo Benevelli, Silvia Sposini, Jordan Lehoux, Nicolas Joubert

Int J Mol Sci· September 2021

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Internalization of Foldamer-Based DNA Mimics through a Site-Specific Antibody Conjugate to Target HER2-Positive Cancer Cells.
Valentina Corvaglia, Imène Ait Mohamed Amar, Véronique Garambois, Stéphanie Letast, Aurélie Garcin, Nicolas Joubert

Pharmaceuticals (Basel)· June 2021

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Antibody-Drug Conjugates: The Last Decade.
Nicolas Joubert, Alain Beck, Charles Dumontet, Caroline Denevault-Sabourin

Pharmaceuticals (Basel)· September 2020

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Frame loads accuracy assessment of semianalytical multibody dynamic simulation methods of a recreational vehicle.
Nicolas Joubert, Maxime Boisvert, Carl Blanchette, Yves St-Amant, Alain Desrochers

Multibody Syst Dyn· July 2020

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Impact of Maleimide Disubstitution on Chemical and Biological Characteristics of HER2 Antibody-Drug Conjugates.
Ofelia Feuillâtre, Camille Gély, Steve Huvelle, Christine B Baltus, Ludovic Juen, Nicolas Joubert

ACS Omega· January 2020

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In Vitro Characterization and Stability Profiles of Antibody-Fluorophore Conjugates Derived from Interchain Cysteine Cross-Linking or Lysine Bioconjugation.
Camille Martin, Guillaume Brachet, Cyril Colas, Emilie Allard-Vannier, Claire Kizlik-Masson, Nicolas Joubert

Pharmaceuticals (Basel)· December 2019

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[Antibody-drug conjugates in oncology. Recent success of an ancient concept].
Alain Beck, Charles Dumontet, Nicolas Joubert

Med Sci (Paris)· December 2019

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[Antibody-drug conjugates in oncology. New strategies in development].
Alain Beck, Charles Dumontet, Nicolas Joubert

Med Sci (Paris)· December 2019

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Antibody-drug conjugates: Design and development for therapy and imaging in and beyond cancer, LabEx MAbImprove industrial workshop, July 27-28, 2017, Tours, France.
Camille Martin, Claire Kizlik-Masson, André Pèlegrin, Hervé Watier, Marie-Claude Viaud-Massuard, Nicolas Joubert

MAbs· January 2019

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Site-Specific Conjugation of Auristatins onto Engineered scFv Using Second Generation Maleimide to Target HER2-positive Breast Cancer in Vitro.
Nicolas Aubrey, Emilie Allard-Vannier, Camille Martin, Francesca Bryden, Stéphanie Letast, Nicolas Joubert

Bioconjug Chem· November 2018

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Impact of Site-Specific Conjugation of ScFv to Multifunctional Nanomedicines Using Second Generation Maleimide.
Katel Hervé-Aubert, Emilie Allard-Vannier, Nicolas Joubert, Zineb Lakhrif, Christophe Alric

Bioconjug Chem· May 2018

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Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody-drug conjugates.
Francesca Bryden, Camille Martin, Stéphanie Letast, Eva Lles, Inmaculada Viéitez-Villemin, Nicolas Joubert

Org Biomol Chem· March 2018

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Towards antibody-drug conjugates and prodrug strategies with extracellular stimuli-responsive drug delivery in the tumor microenvironment for cancer therapy.
Nicolas Joubert, Caroline Denevault-Sabourin, Francesca Bryden, Marie-Claude Viaud-Massuard

Eur J Med Chem· December 2017

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Increment in Drug Loading on an Antibody-Drug Conjugate Increases Its Binding to the Human Neonatal Fc Receptor in Vitro.
Guillaume Brachet, Renaud Respaud, Christophe Arnoult, Corinne Henriquet, Christine Dhommée, Nicolas Joubert

Mol Pharm· April 2016

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Palladium-Catalyzed Amination of N-Free 2-Chloro-7-azaindole.
Aurélie Plas, Camille Martin, Nicolas Joubert, Marie-Claude Viaud-Massuard

Org Lett· October 2015

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B family DNA polymerases asymmetrically recognize pyrimidines and purines.
Travis J Lund, Nisha A Cavanaugh, Nicolas Joubert, Milan Urban, Jennifer N Patro

Biochemistry· August 2011

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Protein chemical modification on endogenous amino acids.
Emmanuel Baslé, Nicolas Joubert, Mathieu Pucheault

Chem Biol· March 2010

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Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate.
Milan Urban, Nicolas Joubert, Byron W Purse, Michal Hocek, Robert D Kuchta

Biochemistry· February 2010

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