Publications by authors named "Dimitris Xirodimas"

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NEDD8, stress granules, and amyotrophic lateral sclerosis: unveiling the therapeutic potential of the NEDP1 protease.
Dimitra Mitsiadou, Dimitris P Xirodimas, Jolanta Polanowska

Essays Biochem· December 2025

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Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses.
Arthur Aubry, Joel D Pearson, Jason Charish, Tao Yu, Jeremy M Sivak, Dimitris P Xirodimas

Cell Rep· November 2025

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NEDD8-specific protease 1 deficiency as a novel driver of hepatoblastoma development through dysregulation of the CAND1-NEDD8 pathway.
L Estefanía Zapata-Pavas, Marina Serrano-Macia, Miguel Ángel Merlos Rodrigo, Jon Ander Barrenechea-Barrenechea, Patricia Peña-SanFelix, Dimitris P Xirodimas

Hepatology· November 2025

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Tardigrade Dsup extends life span by impeding mitochondrial respiration and promoting oxidative stress resistance.
Myriam Richaud, Rohit Shrivastava, Dimitris Xirodimas, Simon Galas, Aymeric Bailly

Sci Adv· October 2025

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SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation.
Ahmed El Motiam, Yanis H Bouzaher, Haifen Chen, Rocío Seoane, Santiago Vidal, Dimitris Xirodimas

Cell Death Dis· July 2025

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A nuclear protein quality control system for elimination of nucleolus-related inclusions.
Lorène Brunello, Jolanta Polanowska, Léo Le Tareau, Chantal Maghames, Virginie Georget, Dimitris P Xirodimas

EMBO J· February 2025

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SUMO2/3 conjugation of TDP-43 protects against aggregation.
Enza Maria Verde, Francesco Antoniani, Laura Mediani, Valentina Secco, Samuele Crotti, Dimitris Xirodimas

Sci Adv· February 2025

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An Anti-Invasive Role for Mdmx through the RhoA GTPase under the Control of the NEDD8 Pathway.
Lara J Bou Malhab, Susanne Schmidt, Christine Fagotto-Kaufmann, Emmanuelle Pion, Gilles Gadea, Dimitris P Xirodimas

Cells· September 2024

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Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway.
Clàudia Gil-Pitarch, Marina Serrano-Maciá, Jorge Simon, Laura Mosca, Carolina Conter, Dimitris Xirodimas

Cell Rep Med· July 2024

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Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses.
Arthur Aubry, Joel D Pearson, Jason Charish, Tao Yu, Jeremy M Sivak, Dimitris P Xirodimas

Cell Rep· February 2024

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SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells.
Rocío Seoane, Tomás Lama-Díaz, Antonia María Romero, Ahmed El Motiam, Arantxa Martínez-Férriz, Dimitris Xirodimas

Cell Mol Biol Lett· January 2024

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Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses.
Arthur Aubry, Joel D Pearson, Jason Charish, Tao Yu, Jeremy M Sivak, Dimitris P Xirodimas

Cell Rep· August 2023

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Targeting the NEDP1 enzyme to ameliorate ALS phenotypes through stress granule disassembly.
Toufic Kassouf, Rohit Shrivastava, Igor Meszka, Aymeric Bailly, Jolanta Polanowska, Dimitris P Xirodimas

Sci Adv· March 2023

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Mixed in chains: NEDD8 polymers in the Protein Quality Control system.
Igor Meszka, Jolanta Polanowska, Dimitris P Xirodimas

Semin Cell Dev Biol· December 2022

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A Mass Spectrometry-Based Strategy for Mapping Modification Sites for the Ubiquitin-Like Modifier NEDD8.
Caio A B Oliveira, Ekaterina Isaakova, Petra Beli, Dimitris P Xirodimas

Methods Mol Biol· December 2022

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Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis.
Marina Serrano-Maciá, Jorge Simón, Maria J González-Rellan, Mikel Azkargorta, Naroa Goikoetxea-Usandizaga, Dimitris P Xirodimas

Mol Metab· November 2021

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The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage.
Aymeric P Bailly, Dimitris P Xirodimas

Biochem Soc Trans· June 2021

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Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.
Sofia Lobato-Gil, Jan B Heidelberger, Chantal Maghames, Aymeric Bailly, Lorene Brunello, Dimitris P Xirodimas

Cell Rep· January 2021

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Antibody RING-Mediated Destruction of Endogenous Proteins.
Adel F M Ibrahim, Linnan Shen, Michael H Tatham, David Dickerson, Alan R Prescott, Dimitris P Xirodimas

Mol Cell· July 2020

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The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity.
Aymeric P Bailly, Aurelien Perrin, Marina Serrano-Macia, Chantal Maghames, Orsolya Leidecker, Dimitris P Xirodimas

Cell Rep· October 2019

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Interplay between SUMOylation and NEDDylation regulates RPL11 localization and function.
Ahmed El Motiam, Santiago Vidal, Carlos F de la Cruz-Herrera, Sabela Da Silva-Álvarez, Maite Baz-Martínez, Dimitris P Xirodimas

FASEB J· January 2019

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NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress.
Chantal M Maghames, Sofia Lobato-Gil, Aurelien Perrin, Helene Trauchessec, Manuel S Rodriguez, Dimitris P Xirodimas

Nat Commun· October 2018

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Quantitative FLIM-FRET Microscopy to Monitor Nanoscale Chromatin Compaction In Vivo Reveals Structural Roles of Condensin Complexes.
David Llères, Aymeric P Bailly, Aurélien Perrin, David G Norman, Dimitris P Xirodimas

Cell Rep· February 2017

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The use of the NEDD8 inhibitor MLN4924 (Pevonedistat) in a cyclotherapy approach to protect wild-type p53 cells from MLN4924 induced toxicity.
Lara J Bou Malhab, Simon Descamps, Benedicte Delaval, Dimitris P Xirodimas

Sci Rep· November 2016

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PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons.
Anne Biever, Emma Puighermanal, Akinori Nishi, Alexandre David, Claire Panciatici, Dimitris Xirodimas

J Neurosci· March 2015

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