Publications by authors named "Dimpy Koul"

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Retraction Note: Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN.
Dimpy Koul, Ranjani Parthasarathy, Ruijun Shen, Michael A Davies, Samar A Jasser

Oncogene· May 2025

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Preclinical and Clinical-Scale Magnetic Particle Imaging of Natural Killer Cells: in vitro and ex vivo Demonstration of Cellular Sensitivity, Resolution, and Quantification.
Olivia C Sehl, Yanwen Yang, Ariana R Anjier, Dmitry Nevozhay, Donghang Cheng, Dimpy Koul

Mol Imaging Biol· February 2025

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Pulsed focused ultrasound alters the proteomic profile of the tumor microenvironment in a syngeneic mouse model of glioblastoma.
Hui Chen, Dimpy Koul, Yanrong Zhang, Sara Natasha Ghobadi, Yayu Zhu

J Neurooncol· November 2024

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MGMT function determines the differential response of ATR inhibitors with DNA-damaging agents in glioma stem cells for GBM therapy.
Vincent W S Leong, Sabbir Khan, Pratibha Sharma, Shaofang Wu, Riya R Thomas, Dimpy Koul

Neurooncol Adv· December 2023

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Neuronal differentiation drives the antitumor activity of mitogen-activated protein kinase kinase (MEK) inhibition in glioblastoma.
Sabbir Khan, Emmanuel Martinez-Ledesma, Jianwen Dong, Rajasekaran Mahalingam, Soon Young Park, Dimpy Koul

Neurooncol Adv· October 2023

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EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.
Jie Ding, Xiaolong Li, Sabbir Khan, Chen Zhang, Feng Gao, Dimpy Koul

Neuro Oncol· October 2022

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PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma.
Shaofang Wu, Xiaolong Li, Feng Gao, John F de Groot, Dimpy Koul

Neuro Oncol· June 2021

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The promise of DNA damage response inhibitors for the treatment of glioblastoma.
Nazanin K Majd, Timothy A Yap, Dimpy Koul, Veerakumar Balasubramaniyan, Xiaolong Li

Neurooncol Adv· February 2021

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Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation.
Nighat Noureen, Shaofang Wu, Yingli Lv, Juechen Yang, W K Alfred Yung, Dimpy Koul

Nat Commun· January 2021

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Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma.
Shaofang Wu, Feng Gao, Siyuan Zheng, Chen Zhang, Emmanuel Martinez-Ledesma, Dimpy Koul

Clin Cancer Res· March 2020

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BRCA1 identified as a modulator of temozolomide resistance in P53 wild-type GBM using a high-throughput shRNA-based synthetic lethality screening.
Jie Ding, Shaofang Wu, Chen Zhang, Arnav Garyali, Emmanuel Martinez-Ledesma, Dimpy Koul

Am J Cancer Res· November 2019

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Tie2-FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma.
Xiaolong Li, Emmanuel Martinez-Ledesma, Chen Zhang, Feng Gao, Siyuan Zheng, Dimpy Koul

Cancer Res· October 2019

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Wild-type defined gamma-secretase inhibitor sensitivity and synergistic activity with doxorubicin in GSCs.
Chen Zhang, Emmanuel Martinez-Ledesma, Feng Gao, Wei Zhang, Jie Ding, Dimpy Koul

Am J Cancer Res· August 2019

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Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.
Patrick Y Wen, Mehdi Touat, Brian M Alexander, Ingo K Mellinghoff, Shakti Ramkissoon, Dimpy Koul

J Clin Oncol· March 2019

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Activation of WEE1 confers resistance to PI3K inhibition in glioblastoma.
Shaofang Wu, Shuzhen Wang, Feng Gao, Luyuan Li, Siyuan Zheng, Dimpy Koul

Neuro Oncol· January 2018

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PAF promotes stemness and radioresistance of glioma stem cells.
Derrick Sek Tong Ong, Baoli Hu, Yan Wing Ho, Charles-Etienne Gabriel Sauvé, Christopher A Bristow, Dimpy Koul

Proc Natl Acad Sci U S A· October 2017

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APOBEC3G acts as a therapeutic target in mesenchymal gliomas by sensitizing cells to radiation-induced cell death.
Yu Wang, Shaofang Wu, Siyuan Zheng, Shuzhen Wang, Arjun Wali, Dimpy Koul

Oncotarget· August 2017

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Preclinical therapeutic efficacy of a novel blood-brain barrier-penetrant dual PI3K/mTOR inhibitor with preferential response in PI3K/PTEN mutant glioma.
Dimpy Koul, Shuzhen Wang, Shaofang Wu, Norihiko Saito, Siyuan Zheng

Oncotarget· March 2017

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MSK1-Mediated β-Catenin Phosphorylation Confers Resistance to PI3K/mTOR Inhibitors in Glioblastoma.
Shaofang Wu, Shuzhen Wang, Siyuan Zheng, Roel Verhaak, Dimpy Koul

Mol Cancer Ther· July 2016

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Retraction: Novel HSP90 inhibitor NVP-HSP990 targets cell-cycle regulators to ablate Olig 2-positive glioma tumor-initiating cells.
Dimpy Koul, Jun Yao, Shuzhen Wan, Ying Yuan, Erik Sulman

Cancer Res· November 2014

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A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.
Norihiko Saito, Jun Fu, Siyuan Zheng, Jun Yao, Shuzhen Wang, Dimpy Koul

Stem Cells· January 2014

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Identification of prognostic gene signatures of glioblastoma: a study based on TCGA data analysis.
Yong-Wan Kim, Dimpy Koul, Se Hoon Kim, Agda Karina Lucio-Eterovic, Pablo R Freire

Neuro Oncol· July 2013

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A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival.
Siyuan Zheng, Jun Fu, Rahulsimham Vegesna, Yong Mao, Lindsey E Heathcock, Dimpy Koul

Genes Dev· July 2013

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Novel HSP90 inhibitor NVP-HSP990 targets cell-cycle regulators to ablate Olig2-positive glioma tumor-initiating cells.
Jun Fu, Dimpy Koul, Jun Yao, Shuzhen Wang, Ying Yuan

Cancer Res· May 2013

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Antitumor activity of NVP-BKM120--a selective pan class I PI3 kinase inhibitor showed differential forms of cell death based on p53 status of glioma cells.
Dimpy Koul, Jun Fu, Ruijun Shen, Tiffany A LaFortune, Shuzhen Wang

Clin Cancer Res· January 2012

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