Publications by authors named "Dirk Schepmann"

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Chiral pool synthesis of enantiomerically pure morphan derivatives with κ receptor affinity from (S)-perillaldehyde.
Lea Flämig, Thomas Schidelko, Luca Blicker, Katharina Hoffmann, Constantin Daniliuc, Dirk Schepmann

Eur J Med Chem· January 2026

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Synthesis and Structure-Affinity Relationships of Receptor Ligands with 1,3-Dioxane Structure.
Elisabeth Quick, Dirk Schepmann, Bernhard Wünsch

Pharmaceuticals (Basel)· August 2025

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Synthesis and structure-affinity relationships of spirocyclic σ receptor ligands with tetrahydropyran scaffold.
Tobias Winge, Dirk Schepmann, Judith Schmidt, Bernhard Wünsch

Eur J Med Chem· January 2025

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Stereoselective Synthesis and Biological Evaluation of Perhydroquinoxaline-Based κ Receptor Agonists.
Jonathan Hoffmann, Dirk Schepmann, Constantin Daniliuc, Marcel Bermudez, Bernhard Wünsch

Int J Mol Sci· January 2025

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2-{-[ω-(1-Benzylpiperidin-4-yl)alkyl]amino}-6-[(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitriles Showing High Affinity for σ Receptors.
Winnie Deuther-Conrad, Dirk Schepmann, Isabel Iriepa, Francisco López-Muñoz, Mourad Chioua

Int J Mol Sci· January 2025

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Two-Step Synthesis of Enantiomerically Pure Morphans from (R)-Carvone.
Giuliana Costanzo, Giuseppe Cosentino, Lorella Pasquinucci, Emanuele Amata, Dirk Schepmann

ChemMedChem· December 2024

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Enantiomerically Pure Indazole Bioisosteres of Ifenprodil and Ro 25-6981 as Negative Allosteric Modulators of NMDA Receptors with the GluN2B Subunit.
Judith Lüken, Gunnar Goerges, Julian A Schreiber, Judith Schmidt, Bastian Frehland, Dirk Schepmann

J Med Chem· November 2024

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Quinolone bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists.
Friederike Rathing, Dirk Schepmann, Bernhard Wünsch

Arch Pharm (Weinheim)· September 2024

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Sigma receptor and aquaporin modulators: chiral resolution, configurational assignment, and preliminary biological profile of RC752 enantiomers.
Roberta Listro, Annamaria Marra, Valeria Cavalloro, Giacomo Rossino, Pasquale Linciano, Dirk Schepmann

J Pharm Biomed Anal· February 2024

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Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives.
Nadine Ritter, Paul Disse, Isabel Aymanns, Lena Mücher, Julian A Schreiber, Dirk Schepmann

Mol Neurobiol· December 2023

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Diastereoselective synthesis and structure-affinity relationships of receptor ligands with spirocyclic scaffold.
Tobias Winge, Dirk Schepmann, Judith Schmidt, Constantin Daniliuc, Ernst-Ulrich Würthwein

Org Biomol Chem· October 2023

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Negative allosteric modulators of NMDA receptors with GluN2B subunit: synthesis of β-aminoalcohols by epoxide opening and subsequent rearrangement.
Marvin Korff, Judith Lüken, Judith Schmidt, Dirk Schepmann, Gunnar Goerges

Org Biomol Chem· September 2023

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Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists.
Judith Lüken, Gunnar Goerges, Nadine Ritter, Paul Disse, Julian A Schreiber, Dirk Schepmann

J Med Chem· August 2023

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Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain.
Giacomo Rossino, Annamaria Marra, Roberta Listro, Marco Peviani, Elena Poggio, Dirk Schepmann

Pharmaceuticals (Basel)· July 2023

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Conformationally Restricted σ Receptor Antagonists from (-)-Isopulegol.
Luca Blicker, Rafael González-Cano, Erik Laurini, Francisco R Nieto, Judith Schmidt, Dirk Schepmann

J Med Chem· April 2023

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Chemical, pharmacodynamic and pharmacokinetic characterization of the GluN2B receptor antagonist 3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1-3-benzazepine-1,7-diol - starting point for PET tracer development.
Marvin Korff, Ruben Steigerwald, Elena Bechthold, Dirk Schepmann, Julian A Schreiber

Biol Chem· March 2023

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Correction to "Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease".
Bengisu Turgutalp, Prabesh Bhattarai, Tugba Ercetin, Chiara Luise, Rengin Reis, Dirk Schepmann

J Med Chem· January 2023

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Phenol-benzoxazolone bioisosteres of GluN2B-NMDA receptor antagonists: Unexpected rearrangement during reductive alkylation with phenylcyclohexanone.
Alexander Markus, Julian A Schreiber, Gunnar Goerges, Bastian Frehland, Dirk Schepmann

Arch Pharm (Weinheim)· November 2022

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Negative allosteric modulators of NMDA receptors with GluN2B subunit: Alanine-derived benzoxazolone bioisosteres of 2-methyl-3-benzazepine-1,7-diols.
Alexander Markus, Bastian Frehland, Dirk Schepmann, Bernhard Wünsch

Arch Pharm (Weinheim)· September 2022

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Phenol-Benzoxazolone bioisosteres: Synthesis and biological evaluation of tricyclic GluN2B-selective N-methyl- d-aspartate receptor antagonists.
Alexander Markus, Julian A Schreiber, Gunnar Goerges, Bastian Frehland, Guiscard Seebohm, Dirk Schepmann

Arch Pharm (Weinheim)· September 2022

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Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease.
Bengisu Turgutalp, Prabesh Bhattarai, Tugba Ercetin, Chiara Luise, Rengin Reis, Dirk Schepmann

J Med Chem· September 2022

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Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil.
Elena Bechthold, Julian A Schreiber, Nadine Ritter, Dirk Schepmann, Constantin Daniliuc

Eur J Med Chem· July 2022

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Synthesis of oxazolo-annulated 3-benzazepines designed by merging two negative allosteric NMDA receptor modulators.
Alexander Markus, Dirk Schepmann, Bernhard Wünsch

Arch Pharm (Weinheim)· June 2022

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Synthesis of Aminoethyl-Substituted Piperidine Derivatives as σ Receptor Ligands with Antiproliferative Properties.
Catharina Holtschulte, Frederik Börgel, Stefanie Westphälinger, Dirk Schepmann, Gianluca Civenni

ChemMedChem· April 2022

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Synthesis of tropane-based σ receptor antagonists with antiallodynic activity.
Elena Bechthold, Julian A Schreiber, Nadine Ritter, Lucie Grey, Dirk Schepmann

Eur J Med Chem· February 2022

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